Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (6): 977-984.doi: 10.3969/j.issn.2095-4344.4006
Zhan Fangbiao1, Cheng Jun1, Zou Xinsen2, Long Jie1, Xie Lizhong1, Deng Qianrong3
Received:
2020-03-19
Revised:
2020-03-24
Accepted:
2020-04-27
Online:
2021-02-28
Published:
2020-12-05
Contact:
Xie Lizhong, Associate chief physician, Department of Orthopedics, Three Gorges Hospital Affiliated to Chongqing University (Chongqing Three Gorges Central Hospital), Chongqing 404000, China
Deng Qianrong, Attending physician, Health Management Center, Three Gorges Hospital Affiliated to Chongqing University (Chongqing Three Gorges Central Hospital), Chongqing 404000, China
About author:
Zhan Fangbiao, Doctoral candidate, Associate chief physician, Department of Orthopedics, Three Gorges Hospital Affiliated to Chongqing University (Chongqing Three Gorges Central Hospital), Chongqing 404000, China
CLC Number:
Zhan Fangbiao, Cheng Jun, Zou Xinsen, Long Jie, Xie Lizhong, Deng Qianrong. Intraoperative intravenous application of tranexamic acid reduces perioperative bleeding in multilevel posterior spinal surgery: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(6): 977-984.
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2.4 Meta分析结果 2.4.1 两组术前血红蛋白及红细胞压积差异的Meta分析结果 有7篇文献详细比较了术前血红蛋白[23-24,26-30],5篇文献详细比较了术前红细胞压积[23,27,29-31]。介绍术前血红蛋白的7篇文献间无异质性(Chi2=6.19,df=6,P=0.40,I2=3%),可以选择固定效应模型进行Meta分析。介绍术前红细胞压积的5篇文献间无异质性(Chi2=1.01,df=4,P=0.91,I2=0%),可以选择固定效应模型进行Meta分析。Meta分析结果显示,两组术前血红蛋白、红细胞压积比较差异无显著性意义[MD= -0.03,95%CI(-0.26,0.20),Z=0.28,P=0.78;MD=0.35,95%CI(-0.17,0.87),Z=1.31,P=0.19],见图4。"
2.4.5 两组术中出血量差异的Meta分析结果 有6篇文献详细比较了术中出血量[23-24,26,27-331]。6篇文献间有异质性(Chi2=331.25,df=5,P < 0.000 01,I2=98%),逐一剔除文献进行敏感性分析,发现剔除COLOMINA等[24]后的总效应量合并值[MD=-23.23,95%CI (-44.00,-2.47)]与未剔除时的总效应量合并值[MD=-145.61,95%CI(-317.48,26.27)]存在较大差异,提示该研究可能导致研究结果不稳定,分析原因可能为COLOMINA等研究中两组患者基线中年龄(P=0.01)和体质量指数(P=0.03)均有显著性差异,故剔除COLOMINA等的研究进行Meta分析。剩余的5篇研究无异质性(Chi2=5.62,df=4,P=0.23,I2=29%)[23,26,29-31],选择固定效应模型进行Meta分析。Meta分析结果显示,氨甲环酸组术中出血量少于安慰剂组[MD=-23.23 ,95%CI(-44.00,-2.47),Z=2.19,P=0.03],见图8。"
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