Regulation of angiogenesis by Notch signaling

doi:10.3969/j.issn.2095-4344.2015.46.022

Abstract

Abstract:

BACKGROUND: The Notch signaling pathway is evolutionarily highly conserved and mediated by cell-cell interactions, which is widely involved in cell differentiation, proliferation and apoptosis. This critical transduction system participates in coordinating various functions of vascular endothelial cells, thus playing a vital role in the formation and remodeling of vascular network.

OBJECTIVE: To elucidate the components of Notch signaling pathway and its impact on angiogenesis.

METHODS: A computer-based online search of PubMed and CBM databases was performed. High-quality articles related to mechanism of angiogenesis regulated by Notch signaling were included, and repetitive studies were excluded.

RESULTS AND CONCLUSION: Totally 31 literatures were selectively included in this review. Angiogenesis is a complicated and muti-stage biological event and has been delicately regulated. Notch signaling participates in the regulation of every stage of angiogenesis directly or indirectly via the crosstalk with vascular endothelial growth factor, BMP-SMAD signaling and extracellular matrix molecules. Furthermore, consistent output of Notch signaling is essential for maintaining the stability and integrity of adult vascular system. This review will thoroughly clarify the latest progress on angiogenesis regulated by Notch signaling and provide theoretical basis and a potential target for designing therapeutic methods against vascular disease.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Receptors, Notch, Signal Transduction, Neovascularization, Physiologic

Wang Zheng, Zhang Ting-wei, Han Xiang-long. Regulation of angiogenesis by Notch signaling[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(46): 7498-7503.

Figures/Tables 1

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