Clinical application of tranexamic acid in perioperative period of total knee arthroplasty

doi:10.3969/j.issn.2095-4344.2015.44.025

Abstract

Abstract:

BACKGROUND: We have not found an effective and safe way to reduce postoperative bleeding after total knee arthroplasty. Tranexamic acid is a synthetic lysine antifibrinolytic drug, can reversibly block the plasminogen binding to fibrin, which prevent degradation of fibrin clots, effectively reduce postoperative bleeding, but this process to reduce bleeding may increase the risk of postoperative venous thrombosis and pulmonary embolism. The present study showed that the optimal use manner of tranexamic acid in the clinic was not clear. There are still a lot of doubts on the risk of postoperative thromboembolic events.
OBJECTIVE: To summarize the effectiveness and safety of three different ways (intravenous, topical and oral) of taking tranexamic acid in total knee arthroplasty.
METHODS: We searched PubMed and Chinese Journal Full-text Database from January 1970 to January 2015 in the title and abstract. The key words were “tranexamic acid; oral; topical; intravenous infusion; blood loss; safety; total knee arthroplasty”. Meta-analysis, review and repeated articles were excluded.
RESULTS AND CONCLUSION: The application of tranexamic acid in the clinic mainly contained intravenous, topical, oral modes. Under the premise of the safe use of tranexamic acid, different modes could control the amount of bleeding to different degrees. It is believed that with the wide use of tranexamic acid during and after total knee arthroplasty, there will be more optimal mode that can better control blood loss after total knee arthroplasty.
中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Arthroplasty, Replacement, Knee, Prosthesis Implantation, Tranexamic Acid, Blood Loss, Surgica, Tissue Engineering

Wang Xin-rui, Wang Tao, Zhang Zhi-qiang. Clinical application of tranexamic acid in perioperative period of total knee arthroplasty[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(44): 7188-7192.

Figures/Tables 1

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