3D printing technology in the construction of tissue-engineered myocardium, heart valve, great vessels and vascular net

doi:10.3969/j.issn.2095-4344.2015.43.026

Abstract

Abstract:

BACKGROUND: The 3D printing that has high-level bionic ability and reproduces subtle and complex structure has been widely used in orthopedics, plastic surgery, medical repair and diagnosis and treatment of cardiovascular diseases.
OBJECTIVE: To review the research about development, advantages and existing problems of the 3D printing technology in building heart valves, blood vessels, tissue-egnieered myocardial tissue and cardiovascular disease models in recent years and to prospect its clinical applications.
METHODS: The PubMed and CNKI databases were searched by the first author for related papers about 3D printing and cardiovascular system published from April 2013 to April 2015. The key words were “3D printing, cardiovascular system, rapid prototyping” in English and Chinese, respectively.
RESULTS AND CONCLUSION: Currently, the 3D printing technology has be applied widely in cardiovascular system research, and achieved a breakthrough in aspects of constructing tissue-engineered myocardium, heart valve, great vessels and vascular net. The 3D printing can be improved gradually from the laboratory application to the clinical application. However, there are still many important issues to be solved. One of the key issues is how to guarantee the blood supply of the targeted organs or tissue. Currently, the basic blood supply of the printed tissues and organs is achieved by the printing tube structure. However, to build the regional microcirculation should be improved because the image reconstruction technique is not suitable to imitate the ultrastructure of capillary.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering, Biocompatible Materials

Wang Lu, Hu Wei-jie, Nie Hao, Sun Xiao-xi, Hong Xian, Xi Jiao-ya. 3D printing technology in the construction of tissue-engineered myocardium, heart valve, great vessels and vascular net[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(43): 7029-7034.

Figures/Tables 2

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