Effect of nanohydroxyapatite/polyamide 66 composite on the vertebral structure and height

doi:10.3969/j.issn.2095-4344.2015.43.017

Abstract

Abstract:

BACKGROUND: Nanohydroxyapatite/polyamide 66 composite is very close to the human cortical bone in terms of mechanical properties, and has osteogenic activity, which is a safe and reliable bone material.
OBJECTIVE: To investigate the effect of nanohydroxyapatite/polyamide 66 composite bioactive supporting material on the restoration of vertebral structure and height.
METHODS: Totally 177 patients with spinal diseases, 116 males and 61 females, aged 17-81 years, were enrolled, including 97 cases of spinal fractures, 5 cases of primary tumors of the spine, 17 cases of spinal tuberculosis and 58 cases of cervical spondylosis. The nanohydroxyapatite/polyamide 66 composite bioactive supporting body was filled into the bone grafts of patients and then subjected to anterior decompression and internal fixation. After 36 months of follow-up, imaging analysis, Frankel spinal cord injury classification, bone graft fusion, visual analog scale scores, Short Form 36 and Japanese Orthopedic Association scores were evaluated.
RESULTS AND CONCLUSION: During the follow-up, except one patient with cervical spine fracture appeared to have slight supporting body displacement, there was no supporting body prolapse or rupture phenomena. The bone graft fusion rate was 96.0%, the average supporting body sinking distance was 1.7 mm. After treatment, 97 patients with spinal fractures had different degree of improvement in the neurological function (P < 0.05); the visual analog scale scores, Short Form 36 and Japanese Orthopedic Association scores were improved significantly in all the 177 patients compared with before treatment (P < 0.05). These results demonstrate that the use of nanohydroxyapatite/polyamide 66 composite bioactive supporting material for spinal reconstruction can improve the bone fusion rate, and restore the vertebral structure and height effectively.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Durapatite, Spinal Fusion, Nylons, Tissue Engineering

Zhang De-sheng, Liu Shu-ping, Liu Yue-hong, Zhou Yu, Chen Xi . Effect of nanohydroxyapatite/polyamide 66 composite on the vertebral structure and height[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(43): 6977-6982.

Figures/Tables 3

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