Calcium phosphate cement II induces osteogenesis and repairs tendon-bone interface injury: a biomechanical analysis

doi:10.3969/j.issn.2095-4344.2015.43.001

Abstract

Abstract:

BACKGROUND: Both calcium phosphate cement II and recombinant human bone morphogenetic protein have certain osteoinductive effects, which have the possibility of repairing tendon-bone interface injury.
OBJECTIVE: To investigate the osteoinductive effect of calcium phosphate cement II and its biomechanics analysis of repairing tendon-bone interface injury.
METHODS: Five out of 35 adult healthy New Zealand white rabbits were randomly selected and their bilateral shoulder joint tendon-bone interface specimens were taken as normal control group after being sacrificed. The remaining 30 rabbits were used to make animal models of tendon-bone interface injury and then randomly divided into experimental and model groups. Rabbits in the model group had no treatment, and those in the experimental group were treated with calcium phosphate cement II.
RESULTS AND CONCLUSION: After repair with calcium phosphate cement II, the injured tendon-bone interface of rabbits was obviously restored, and the repair effect became better with time. The expression level of bone morphogenetic protein 2 was also increased accordingly. The maximum tensile strength and the maximum stiffness of the injured tendon-bone interface were obviously increased. These results demonstrate that calcium phosphate cement II combined with recombinant human bone morphogenetic protein has good osteoinductive and repair effect in repair of tendon-bone interface injury.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Calcium Phosphates, Tendons, Shoulder Joint, Prostheses and Implants, Tissue Engineering

Li Xiao-fei, Xie Wen-jin, Sheng Lu-xin, Yuan Xi. Calcium phosphate cement II induces osteogenesis and repairs tendon-bone interface injury: a biomechanical analysis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(43): 6889-6894.

Figures/Tables 5

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