How to build a tissue-engineered intervertebral disc annulus fibrosus that is more close to the natural one?

doi:10.3969/j.issn.2095-4344.2015.42.020

Abstract

Abstract:

BACKGROUND: Tissue-engineered intervertebral disc has provided a new biological therapeutic approach for intervertebral disc degeneration. Tissue-engineered annulus fibrosus is one key step of constructing a complete tissue-engineered intervertebral disc.
OBJECTIVE: To sum up the research progress of tissue-engineered annulus fibrosus from the following aspects: structural features, scaffold materials, seed cells.
METHODS: PubMed database and Wanfang database (2000-2015) were retrieved by the key words of “tissue engineering, intervertebral disc, annulus fibrosus, seed cell, scaffold, construction” in Chinese and in English, respectively. According to inclusion and exclusion criteria, 48 literatures were involved for summarization.
RESULTS AND CONCLUSION: Previous studies about tissue-engineered annulus fibrosus only focused on cell adhesion, proliferation and extracellular matrix secretion on the scaffold. Currently, tissue-engineered annulus fibrosus exhibit similar features to the natural annulus fibrosus in the following aspects: cell function, tissue structure and mechanical features, and relevant animal experiments have achieved certain results in animal experiments. However, it is still difficult to build a tissue-engineered annulus fibrosus entirely similar to the natural one, and we need to further improve scaffold materials, culture conditions, collection of seed cells. The current strategies of annulus fibrosus construction still focus on single phase of scaffold, and the biphasic scaffold and complete intervertebral disc scaffold will be the trend of the researches. Technology of induced differentiation of stem cells provides a broach source of seed cells for tissue-engineered annulus fibrosus.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Intervertebral Disk, Stents, Stem Cells

Yuan De-chao, Chen Zhu, Feng Da-xiong, Feng Gang. How to build a tissue-engineered intervertebral disc annulus fibrosus that is more close to the natural one?[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(42): 6832-6837.

Figures/Tables 1

References

[1] 冯刚.椎间盘退行性变疾病不同临床期生物治疗策略[J].西部医学. 2013;25(8):1121-1127.
[2] 冯刚.椎间盘组织工程研究的挑战与对策[J].西部医学,2010, 22(8):1377-1379.
[3] Sharifi S,Bulstra SK,Grijpma DW,et al.Treatment of the degenerated intervertebral disc; closure, repair and regeneration of the annulus fibrosus. J Tissue Eng Regen Med.2014; 3(13):53-67.
[4] Silva-Correia J,Correia SI,Oliveira JM,et al. Tissue engineering strategies applied in the regeneration of the human intervertebral disk. Biotechnol Adv. 2013;31(8): 1514-1531.
[5] Jin L, Shimmer AL,Li X. The challenge and advancement of annulus fibrosus tissue engineering. Eur Spine J. 2013;22(5): 1090-1100.
[6] Gantenbein B, Illien-Junger S, Chan SC, et al.Organ culture bioreactors - platforms to study human intervertebral disc degeneration and regenerative therapy.Curr Stem Cell Res Ther.2015;3(13):1574-1582 .
[7] Wu XL, Wu LJ, Zheng RM, et al. Biomechanical characteristics analysis on discs with coflex fixation on the different segments of lower lumbar spine. Zhongguo Gu Shang. 2014;27(11):938-942.
[8] Blanquer SB, Grijpma DW,Poot AA. Delivery systems for the treatment of degenerated intervertebral discs. Adv Drug Deliv Rev.2014;3(12):48-55.
[9] Gebhard H,Bowles R,Dyke J,et al.Total disc replacement using a tissue-engineered intervertebral disc in vivo: New animal model and initial results. Evid Based Spine Care J. 2010;1(2):62-66.
[10] Zhu D, Chen S, Dong X, et al. An observation on the micro-structure and form of annulus fibrosus of lumbar interverbral disc 4, 5. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi.2007;24(4):842-845.
[11] Ayturk UM, Garcia JJ, Puttlitz CM. The micromechanical role of the annulus fibrosus components under physiological loading of the lumbar spine.J Biomech Eng.2010;132(6): 1007-1018.
[12] Kular JK, Basu S,Sharma RI. The extracellular matrix: structure, composition, age-related differences, tools for analysis and applications for tissue engineering. J Tissue Eng.2014;45(5):112-122.
[13] Hosseinkhani M, Mehrabani D, Karimfar MH, et al. Tissue engineered scaffolds in regenerative medicine. World J Plast Surg.2014;3(1):3-7.
[14] Shao X, Hunter CJ. Developing an alginate/chitosan hybrid fiber scaffold for annulus fibrosus cells. J Biomed Mater Res A.2007;82(3):701-710.
[15] Nesti LJ, Li WJ, Shanti RM, et al. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (hanfs) amalgam. Tissue Eng Part A.2008;14(9):1527-1537.
[16] 赵鑫,黄师,严宁,等. 藻酸盐凝胶支架在生物学修复椎间盘退行性变中的应用[J]. 中国组织工程研究与临床康复, 2008,12(1): 73-76.
[17] Guillaume O, Daly A, Lennon K, et al. Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: Effect of tgf-beta3 supplementation and oxygen culture conditions. Acta Biomater.2014;10(5):1985-1995.
[18] Chang G, Kim HJ, Vunjak-Novakovic G, et al. Enhancing annulus fibrosus tissue formation in porous silk scaffolds. J Biomed Mater Res A. 2010; 92(1): 43-51.
[19] Chang G, Kim HJ, Kaplan D, et al. Porous silk scaffolds can be used for tissue engineering annulus fibrosus. Eur Spine J.2007;16(11): 1848-1857.
[20] Park SH, Gil ES, Mandal BB, et al. Annulus fibrosus tissue engineering using lamellar silk scaffolds. J Tissue Eng Regen Med.2012;6(3):24-33.
[21] Bhattacharjee M, Miot S, Gorecka A,et al.Oriented lamellar silk fibrous scaffolds to drive cartilage matrix orientation: Towards annulus fibrosus tissue engineering. Acta Biomater. 2012;8(9):3313-3325.
[22] Blanquer SB, Sharifi S,Grijpma DW.Development of poly(trimethylene carbonate) network implants for annulus fibrosus tissue engineering. J Appl Biomater Funct Mater. 2012; 10(3): 177-184.
[23] Attia M, Santerre JP, Kandel RA. The response of annulus fibrosus cell to fibronectin-coated nanofibrous polyurethane-anionic dihydroxyoligomer scaffolds. Biomaterials. 2011;32(2):450-460.
[24] Hegewald AA, Medved F, Feng D, et al.Enhancing tissue repair in annulus fibrosus defects of the intervertebral disc: Analysis of a bio-integrative annulus implant in an in-vivo ovine model.J Tissue Eng Regen Med. 2013;11(15):79-91.
[25] Wismer N, Grad S, Fortunato G, et al.Biodegradable electrospun scaffolds for annulus fibrosus tissue engineering: Effect of scaffold structure and composition on annulus fibrosus cells in vitro. Tissue Eng Part A. 2014; 20(3):672-682.
[26] Wan Y, Feng G, Shen FH, et al. Novel biodegradable poly(1,8-octanediol malate) for annulus fibrosus regeneration. Macromol Biosci.2007; 7(11): 1217-1224.
[27] 李玉东,徐源,周强,等. 聚乳酸-聚己内酯组织工程纤维环支架的制备及其性能研究[J]. 第三军医大学学报，2014;36(9): 914-918.
[28] Pirvu T, Blanquer SB, Benneker LM, et al. A combined biomaterial and cellular approach for annulus fibrosus rupture repair. Biomaterials.2015;42(11): 11-19.
[29] Wan Y, Feng G, Shen FH, et al. Biphasic scaffold for annulus fibrosus tissue regeneration. Biomaterials.2008;29(6): 643-652.
[30] Park SH, Gil ES, Cho H, et al. Intervertebral disk tissue engineering using biphasic silk composite scaffolds. Tissue Eng Part A. 2012;18(5-6): 447-458.
[31] Sakai D, Andersson GB.Stem cell therapy for intervertebral disc regeneration: Obstacles and solutions. Nat Rev Rheumatol.2015;2(24):243-256.
[32] Rodrigues-Pinto R,Richardson SM,Hoyland JA. An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration. Eur Spine J. 2014;23(9):1803-1814.
[33] Gantenbein B,Calandriello E,Wuertz-Kozak K,et al.Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia. BMC Musculoskelet Disord. 2014;15(7):422-429.
[34] Hegewald AA, Cluzel J, Kruger JP, et al.Effects of initial boost with tgf-beta 1 and grade of intervertebral disc degeneration on 3d culture of human annulus fibrosus cells. J Orthop Surg Res.2014; 9(21):73-79.
[35] Chuah YJ, Lee WC, Wong HK, et al.Three-dimensional development of tensile pre-strained annulus fibrosus cells for tissue regeneration: An in-vitro study. Exp Cell Res. 2015; 331(1):176-182.
[36] Acosta FL Jr., Metz L, Adkisson HD, et al. Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells. Tissue Eng Part A.2011; 17(23-24): 3045-3055.
[37] Buhrmann C, Busch F, Shayan P, et al. Sirtuin-1 (sirt1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. J Biol Chem. 2014;289(32): 22048-22062.
[38] Shen J, Gao Q, Zhang Y, et al.Autologous plateletrich plasma promotes proliferation and chondrogenic differentiation of adiposederived stem cells. Mol Med Rep. 2015;11(2): 1298-1303.
[39] 冯均伟,王跃,吕波,等. 骨髓间充质干细胞体外诱导成软骨细胞的动态观察[J].中国组织工程研究,2013;17(36):6409-6416.
[40] 张清林,吕惠成,吴一民. 转化生长因子1联合骨形态发生蛋白2诱导骨髓间充质干细胞体外向软骨细胞的分化[J].中国组织工程研究与临床康复,2010,14(24):4371-4375.
[41] Toguchida J. Advancement of regenerative medicine in the locomotive system using ips cells. Clin Calcium.2014;24(4): 587-592.
[42] See EY, Toh SL, Goh JC. Simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell sheets and silk scaffolds for annulus fibrosus regeneration.J Tissue Eng Regen Med.2012;6(7):528-535.
[43] Guzzo RM, Scanlon V, Sanjay A, et al.Establishment of human cell type-specific ips cells with enhanced chondrogenic potential.Stem Cell Rev. 2014;10(6):820-829.
[44] Griffin M, Iqbal SA, Bayat A. Exploring the application of mesenchymal stem cells in bone repair and regeneration.J Bone Joint Surg Br. 2011;93(4):427-434.
[45] Leung VY, Tam V, Chan D, et al. Tissue engineering for intervertebral disk degeneration. Orthop Clin North Am.2011; 42(4): 575-583.
[46] O'Halloran DM, Pandit AS. Tissue-engineering approach to regenerating the intervertebral disc. Tissue Eng. 2007; 13(8): 1927-1954.
[47] 胡稷杰,裴国献,全大萍,等. 新型聚乳酸-羟基乙酸(PLGA)支架的细胞相容性研究[J]. 中华创伤骨科杂志. 2005; 7(4): 358-362.
[48] Henry N, Colombier P, Lescaudron L, et al.Regenerative medicine of the intervertebral disc: From pathophysiology to clinical application. Med Sci (Paris). 2014;30(12):1091-1100.