Role of insulin-like growth factor in the orthodontic periodontal tissue remodeling

doi:10.3969/j.issn.2095-4344.2015.42.019

Abstract

Abstract:

BACKGROUND: Orthodontic treatment is a mechanical force for tooth to cause the remodeling of periodontal tissue, produced by the tooth movement. The main aspect of orthodontic periodontal tissue remodeling is the alveolar bone. Insulin-like growth factor is an important factor in the remodeling of periodontal tissue, which plays an important role in the growth, differentiation and growth of the cells.
OBJECTIVE: To review the role of insulin-like growth factors in periodontal tissue remodeling.
METHODS: A computer-based retrieval of PubMed, CNKI and Guizhou Province Digital Library Database was
performed to search articles related to the role of insulin-like growth factors in periodontal tissue remodeling. The keywords were “insulin-like growth factor; periodontal tissue; remodeling” in English and Chinese, respectively.
RESULTS AND CONCLUSION: Insulin like growth factor belongs to the insulin family, a kind of peptides, which can promote the migration, proliferation, differentiation, collagen and matrix synthesis and alkaline phosphatase activity of osteoblasts, fibroblasts and mesenchymal cells in the periodontal ligament. It also plays an important role in the repair of injury. During orthodontic treatment, the use of suitable orthodontic force combined with insulin-like growth factor can promote periodontal tissue remodeling, accelerate the orthodontic tooth movement and shorten the treatment time for patients.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Insulin-Like Growth Factor I, Periodontium, Fibroblasts, Tissue Engineering

Lang Yao-ling, Guan Xiao-yan, Liu Jian-guo. Role of insulin-like growth factor in the orthodontic periodontal tissue remodeling[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(42): 6826-6831.

Figures/Tables 1

References

[1] 卢劲晔,王锦峰,卢炜,等.胰岛素样生长因子1研究进展[J].畜牧与兽医,2014,46(5):116-118.
[2] 黄波,王俊娟,许华燕.胰岛素样生长因子在牙周组织工程中作用的研究进展[J].现代生物医学进展,2012,12(21):4183-4185.
[3] Bortvedt SF,Lund PK. Insulin-like growth factor1: common mediator of multiple enterotrophic hormones and growth factors.Curr Opin Gastroenterol.2012;28(2): 89-98.
[4] 吴国柱,郭跃先,杨士杰.胰岛素样生长因子-1( IGF-1) 的临床应用进展[J].河北医药,2015,37(9):1398-1400.
[5] 吴金枝,刘新庆.胰岛素样生长因子-Ⅰ与错牙合畸形关系的研究进展[J].中国美容医学,2015,24(6):83-85.
[6] 杨季红,程树杰.IGF-2和H19与肿瘤关系的研究进展[J].河北医药,2011,33(18):2836-2839.
[7] 李瑞,潘玉琴.胰岛素样生长因子２的基因组印迹与疾病相关性研究进展[J].国际检验医学杂志,2012,33(16):1983-1984.
[8] 万贤凤,兰泽栋,曾琳,等.人重组骨形成蛋白-4与人重组胰岛素样生长因子-联合应用对大鼠成骨细胞的影响[J].广东牙病防治, 2013,21(3):127-130.
[9] Sheng MH,Lau KH,Baylink DJ.Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone.J Bone Metab.2014;21(1):41-54.
[10] Yu Y, Mu J, Fan Z,et al.Insulin-like growth factor 1 enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells via ERK and JNK MAPK pathways.Histochem Cell Biol.2012;137(4):513–525.
[11] Kémoun P, Gronthos S, Snead ML,et al. The role of cell surface markers and enamel matrix derivatives on human periodontal ligament mesenchymal progenitor responses in vitro. Biomaterials.2011;32(30):7375-7388.
[12] 孙吏聪,李松,张玉昆.IGF-1诱导外胚间充质细胞向成骨细胞分化的实验研究[J].河南科技大学学报,2014,32(1):3-6.
[13] 宋静,何健民,李珊.牙周膜干细胞成骨分化中细胞因子的作用[J].中国组织工程研究,2013,17(10):1821-1826.
[14] 孙海钰,张彬,管涛,等.胰岛素样生长因子-1对成纤维细胞向成骨细胞转化的影响[J].中华创伤骨科杂志,2012,14(1):49-52.
[15] 彭莉,李双庆.β2 肾上腺素能受体激动剂/拮抗剂对大鼠OB IGF-I受体mＲNA表达的影响[J].中国骨质疏松杂志,2014, 20(5): 490-494.
[16] 郭玲,王敏,郝直.胰岛素样生长因子1对小鼠成骨细胞增殖和碱性磷酸酶活性的影响[J].2010,14(33):6095-6098.
[17] 赵荣兰,彭效祥,宋伟,等.破骨细胞对IGF-1诱导成骨细胞骨同化的促进作用[J].中国骨质疏松杂志,2013,19(2):114-119.
[18] Chen LL,Wang K,Zhang J,et al. Effect of the bone resorption supernatant from RAW264.7 osteoclast on the osteogenic activity of mouse MC3T3-E1 cell.Zhonghua Kou Qiang Yi Xue Za Zhi.2012;47(1):32-37.
[19] Li F, Li G, Hu H, et al. Effect of parathyroid hormone on experimental tooth movement in rats. Am J Orthod Dentofacial Orthop.2013;144(4):523-532.
[20] Fang Y, Wang LP, Du FL, et al. Effects of insulin-like growth factor I on alveolar bone remodeling in diabetic rats.J Periodontal Res.2013;48(2):144-150.
[21] Zou W, Teitelbaum SL.Integrins, growth factors, and the osteoclast cytoskeleton. Ann N Y Acad Sci. 2010;1192(1): 27-31.
[22] Schneider JG, Amend SR, Weilbaecher KN. Integrins and bone metastasis: integrating tumor cell and stromal cell interactions.BONE.2011;48(1):54-65.
[23] 梁颖,刘建国,徐宇红,等.胰岛素样生长因子1对大鼠正畸牙牙周膜细胞整合素αv、β3表达的影响[J].广东牙病防治, 2013,(6): 285-289.
[24] Alfaqeeh SA, Gaete M, Tucker AS. Interactions of the tooth and bone during development. J Dent Res. 2013;92(12): 1129-1135.
[25] Martin TJ. Historically significant events in the discovery of RANK/RANKL/OPG. World J Orthop. 2013;4(4): 186-197.
[26] Tsubaki M, Komai M, Itoh T, et al. Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation. J Biomed Sci. 2014;21(1):10.
[27] 梁颖.IGF-1对大鼠正畸牙牙周组织改建的影响[D].遵义:遵义医学院,2007.
[28] 陈慧中,卜欠欠,孔卫东,等.尼古丁对人牙周膜成纤维细胞超微结构及分泌细胞因子的影响[J].中国病理生理杂志,2013,29(2): 324-329.
[29] 郑巍,王石.IGF-1对人牙周膜干细胞成骨能力的影响[J].现代口腔医学杂志,2011,23(4):286-288.
[30] 赵博,王永兰.复合胰岛素样生长因子1壳聚糖胶原支架与人牙周膜细胞的增殖[J].中国组织工程研究,2014,18(8):1231-1236.
[31] Kerstin S,Kristina A,Kamal M,et al.Response of Bone and Periodontal Ligament Cells to Biodegradable Polymer Scaffolds In Vitro.J Bioact Compat Polym.2010;25(6): 584-602.
[32] Xu C, Lei C, Meng L, et al. Chitosan as a barrier membrane material in periodontal tissue regeneration.J Biomed Mater Res B Appl Biomater.2012;100(5):1435-1443.
[33] 张林,谢鑫,王俊岩,等.补肾和补肾健脾方对尾部悬吊大鼠股骨骨丢失的作用研究[J].中华中医药杂志,2014,29(3):700-703.
[34] Duan F,Yang C,Yang H,et al.Effect of retinoic acid on alkaline phosphatase expression in rat adipose-derived stem cells.Nan Fang Yi Ke Da Xue Xue Bao.2012;32(1):32-36.
[35] Dror DK,King JC,Fung EB,et al.Evidence of associations between feto-maternal vitamin d status, cord parathyroid hormone and bone-specific alkaline phosphatase, and newborn whole body bone mineral content.Nutrients. 2012; 4(2):68-77.
[36] 徐皑,吴桂堂,刘兴容.胰岛素样生长因子-Ⅰ和转化生长因子-β1对人牙髓干细胞增殖和分化影响的研究[J].现代预防医学, 2014,41(12):2237-2240.
[37] Nuñez J, Sanz-Blasco S, Vignoletti F ,et al.Periodontal regeneration following implantation of cementum and periodontal ligament-derived cells.J Periodontal Res.2012; 47(1):33-44.
[38] Kerkis I, Caplan AI.Stem Cells in Dental Pulp of Deciduous Teeth.Tissue Eng Part B Rev.2012;18(2):129-138.
[39] Dangaria SJ, Ito Y, Luan X, et al. Successful Periodontal Ligament Regeneration by Periodontal Progenitor Preseeding on Natural Tooth Root Surfaces. Stem Cells Dev.2011; 20(10): 1659-1668.
[40] Molinelli A, Bonsignore A, Cicconi M ,et al.IGF-1 abuse in sport: clinical and medico-legal aspects.J Sports Med Phys Fitness. 2010;50(4):530-535.
[41] 落全祥,齐鸿亮,高莺,等.局部应用类胰岛素样生长因子1对兔下颌骨缺损愈合相关血生化指标影响的研究[J].中国药物与临床, 2014,14(3):293-295.