Denervation of the inferior alveolar nerve is associated with bone formation and bone mass maintenance in extraction sockets

doi:10.3969/j.issn.2095-4344.2015.42.004

Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (42): 6740-6745.doi: 10.3969/j.issn.2095-4344.2015.42.004

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Denervation of the inferior alveolar nerve is associated with bone formation and bone mass maintenance in extraction sockets

Wang Cheng-yong^{1, 2}, Chen Wei-hui^{1, 2}, Lu Meng^{1, 2}, Wang Jin^{1, 2}, Mao Chuan-qing^{1, 2}, Lin Hai³

1Department of Maxillofacial Deformity Prevention, Fujian Medical University, Fuzhou 350001, Fujian Province, China; 2Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China; 3Department of Dental Implantation, Xiamen Stomatological Hospital, Xiamen 361000, Fujian Province, China

Online:2015-10-08 Published:2015-10-08
Contact: Chen Wei-hui, M.D., Master’s supervisor, Associate professor, Department of Maxillofacial Deformity Prevention, Fujian Medical University, Fuzhou 350001, Fujian Province, China; Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China
About author:Wang Cheng-yong, Master, Attending physician, Department of Maxillofacial Deformity Prevention, Fujian Medical University, Fuzhou 350001, Fujian Province, China; Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China
Supported by:
the National Natural Science Foundation of China, No. 31070838; the Natural Science Foundation of Fujian Province, No. 2012J06017; the Youth Fund of Fujian Provincial Health Department, No. 2012-1-20

Abstract

Abstract:

BACKGROUND: There is a close relationship between innervations and bone formation and bone mass maintenance in the extraction sockets.

OBJECTIVE: To study the possible effect of denervations on the regulation of new bone formation and bone mass maintenance in the extraction sockets.

METHODS: The unilateral inferior nerve of dogs was sectioned to establish an animal denervation model. The normal side was used as control. After model establishment, the premolars of denervated side and normal side were extracted. Histological method was used to test new bone formation and bone mass maintenance in the extraction sockets at the 2^nd, 4^th, 8^th and 12^th weeks after tooth extraction.

RESULTS AND CONCLUSION: The percentage of new bone areas in the extraction sockets was significantly lower in the experiment group than the control group at weeks 2, 4, 8 after tooth extraction (P < 0.01). The height difference between the buccal and lingual alveolar ridge was higher in the experimental group than the control group at weeks 2, 4, 8, 12 after tooth extraction (P < 0.05 or P < 0.01). These findings indicate that denervation is closely related with new bone formation and bone mass maintenance in the extraction sockets.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Mouth, Osteogenesis

Wang Cheng-yong, Chen Wei-hui, Lu Meng, Wang Jin, Mao Chuan-qing, Lin Hai. Denervation of the inferior alveolar nerve is associated with bone formation and bone mass maintenance in extraction sockets[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(42): 6740-6745.

Figures/Tables 6

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Denervation of the inferior alveolar nerve is associated with bone formation and bone mass maintenance in extraction sockets

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