Lumbar disc degeneration: tissue engineering repair and biomechanical evaluation

doi:10.3969/j.issn.2095-4344.2015.37.022

Abstract

Abstract:

BACKGROUND: At present, the clinical treatment of lumbar disc degeneration mainly includes conservative treatment, traditional surgery and minimally invasive surgery. The therapeutic purpose is to relieve symptoms, but the long-term effect is not very satisfactory. Therapeutic methods focusing on biological functional recovery have been concerned gradually, but the clinical application is far in sight.

OBJECTIVE: To review the advances in the treatment of lumbar disc degeneration regarding tissue-engineered repair and biomechanics.

METHODS: PubMed database was searched by the first author for relevant articles published before December 2014 using the keywords of “intervertebral disc degeneration, clinical treatment, biological treatment, tissue engineering, biomechanics, repair, progress” in English. A total of 100 articles were searched initially and finally, 40 articles were included in result analysis.

RESULTS AND CONCLUSION: Although the therapeutic schemes are varied, the treatment of intervertebral disc degeneration is a great challenge for clinicians and basic researchers. Currently there is no perfect clinical treatment, and indications corresponding to various therapies should be paid attention as well as long-term follow-up evaluation. For various reasons, the biological treatment for intervertebral disc degenerative disease is becoming more and more popular, providing a promising prospect for the treatment of intervertebral disc degeneration. So far, large amounts of data have been obtained from animal experiments, but there are still many problems to be solved. Other challenges also involve the all aspects of general tissue engineering methods, such as cells, cytokines and scaffolds. In these studies, the nucleus pulposus tissue engineering based on the combination of heparin-functionalized chitosan hydrogel, cytokines and stem cells exhibits a promising prospect.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Lumbar Vertebrae, Intervertebral Disk Degeneration, Biomechanics, Tissue Engineering

CLC Number:

R318

Dong Shi-shi, Li Jing-feng, Zhou Yi-chi, Zha Yuan-yu, Jin Wei . Lumbar disc degeneration: tissue engineering repair and biomechanical evaluation[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(37): 6024-6030.

Figures/Tables 1

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