Mesenchymal stem cell transplantation for spinal cord injury: a Meta-analysis

doi:10.3969/j.issn.2095-4344.2015.36.023

Abstract

Abstract:

BACKGROUND: In recent years, the effectiveness of stem cell transplantation in the treatment of spinal cord injury has been validated in animal models, and mesenchymal stem cell transplantation for treatment of spinal cord injury has been studied most widely. Currently, there are a number of relevant clinical studies that have shown a good prospect.

OBJECTIVE: To evaluate the efficacy and safety of mesenchymal stem cell transplantation for spinal cord injury in human with a system review.

METHODS: PubMed database, EMBASE database, Cochrane Library, ISI Web of knowledge, CBM database, VIP database, CNKI database and Wanfang database were searched from their start year up to July 2015 for relevant randomized clinical trials on the treatment of spinal cord injury with mesenchymal stem cell transplantation. The key words were “spinal cord injury, paraplegia, cell transplantation, transplantation,mesenchymal stem cell, bone marrow transplantation, stem cell, randomized controlled trial” in English and Chinese, respectively.

RESULTS AND CONCLUSION: A total of 260 articles were retrieved, including 6 randomized clinical trials (252 cases). In the aspects of ASIA touch sensation score, overall Frankel score and daily life activity training score, the patients undergoing mesenchymal stem cell transplantation were significantly superior to those in the control group (P < 0.05). In addition, ASIA motor function score and residual urine volume were also improved in the patients undergoing mesenchymal stem cell transplantation, but there was no statistical difference (P > 0.05). Compared with the control group, low fever was more common in the patients undergoing mesechymal stem cell transplantation (P < 0.05). Another side effect was lower limb numbness, but there was no difference from the control group (P > 0.05). These findings suggest that mesenchymal stem cell transplantation has limited efficacy in the treatment of spinal cord injury and cannot induce severe complications, but there is a need for high-quality randomized controlled trials to prove the efficiency and safety of mesenchymal stem cell transplantation for the treatment of spinal cord injury.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Mesenchymal Stem Cell Transplantation, Spinal Cord Injuries, Meta-Analysis

CLC Number:

R394.2

Zhao Wen-tao, Li Pan-pan, Zhang Hai-feng, Wu Na-ping, Liang Jian-fang. Mesenchymal stem cell transplantation for spinal cord injury: a Meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(36): 5865-5871.

Figures/Tables 5

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