Stem cell-induced proliferation of myocardial cells and exercise-induced regeneration of myocardial cells

doi:10.3969/j.issn.2095-4344.2015.36.024

Abstract

Abstract:

BACKGROUND: Stem cell transplantation has incomparable superiorities in the treatment of cardiovascular diseases. But stem cells have a very low efficiency to differentiate into myocardial cells spontaneously, and there are many factors influencing stem cell differentiation.

OBJECTIVE: To clarify the pros and cons of different sources of stem cells in the treatment of myocardial infarction, to investigate the methods for improving the differentiation efficiency of myocardial cells, optimal differentiation conditions and mechanism underlying exercise-induced stem cell mobilization and endogenous myocardial cell regeneration.

METHODS: A computer-based search of CNKI and PubMed databases was performed by the first author for articles related to stem cell therapy for myocardial infarction and stem cell differentiation into myocardial cells, exercise effect on stem cell proliferation and myocardial cell regeneration published from 1985 to 2015. The key words were “stem cells, myocardial infarction, myocardial regeneration, cardiac cell, exercise” in Chinese and English, respectively. Finally, 54 articles were included in result analysis.

RESULTS AND CONCLUSION: In recent years, a variety of chemical inducers and biological components have been used in the myocardial differentiation of stem cells. Simulation of myocardial microenvironment and vascular cell growth factors are the main methods of inducing myocardial differentiation. Aerobic exercise-induced stem cell mobilization can induce ischemic cardiac angiogenesis and upregulate a variety of vascular endothelial growth factors so as to promote myocardial proliferation and repair. However, in-depth exploration is still needed in the harvesting of stem cells, transplant rejection, and regulatory mechanisms underlying the directed differentiation of stem cells into cardiomyocytes.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Myocardial Infarction, Myocytes, Cardiac, Cell Differentiation

CLC Number:

R318

Chen Guang-tao1 Zhang Lan, Ren Wen-jun. Stem cell-induced proliferation of myocardial cells and exercise-induced regeneration of myocardial cells[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(36): 5872-5877.

Figures/Tables 1

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