Advances in scar prevention, early intervention and clinical assessment

doi:10.3969/j.issn.2095-4344.2015.20.026

Abstract

Abstract:

BACKGROUND: Potential mechanisms of scar formation and scar prevention strategies have become more important in current medical research. Scar assessment scales have the potential to contribute to better evaluation of scar properties in both research and clinical diagnosis.
OBJECTIVE: To summarize the literatures addressing scar prevention and clinical assessment.
METHODS: A computer search of CNKI database from 2000 to 2014, PubMed database from 1975 to 2014 and Foreign Medical Journal Full-Text Service Database from 2000 to 2014 was performed using the keywords of “scar, prevention, treat, cicatrix, assessment, measure” in Chinese and English to retrieve articles related to scar prevention strategies and scar assessment scales. Totally 39 articles meeting the inclusive criteria were included in result analysis.
RESULTS AND CONCLUSION: During wound healing, the unbalance between collagen anabolism and katabolism can lead to the formation of pathological scar. Prevention and treatment of pathological scars should be combined, and early intervention was used in wound healing. General scar assessment scales include Vancouver Scar Scale,
Visual Analog Scale, Patient and Observer Scar Assessment Scale, Manchester Scar Assessment Scale, Stony Brook Scar Assessment Scale, all of which have the potential to contribute to better evaluation of scar properties in both research and clinical diagnosis.

Key words: Cicatrix, Keloid, Wound Healin

CLC Number:

R318

Ma Lin-xiao, Bao Ji-hong, Chen Bin . Advances in scar prevention, early intervention and clinical assessment[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(20): 3253-3257.

Figures/Tables 1

References

[1] 陈惠平,张余光,张涤生,等.创伤后瘢痕的临床评估及综合治疗[J].整形再造外科杂志,2004,1(2):113-117.

[2] Monstrey S, Middelkoop E, Vranckx JJ, et al. Updated Scar Management Practical Guidelines: Non-invasive and invasive measures. J Plast Reconstr Aesthet Surg. 2014;67(8):1017- 1025.

[3] 黄国锋,夏照帆.瘢痕防治的临床方案及国际推荐意见[J].中华烧伤杂志,2011,27(3):240-242.

[4] 胡大海，刘佳琦.伍重道远.进一步加强瘢痕的基础与临床研究[J].中华烧伤杂志,2011,27(6):407-410.

[5] Hinz B. Formation and Function of the Myofibroblast during Tissue Repair. J Invest Dermatol. 2007 Mar;127(3):526-537.

[6] Mustoe TA CR, Gold MH, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002 Aug;110(2):560-571.

[7] Atiyeh BS EKA, Dibo SA. Pressure garment therapy (PGT) of burn scars: evidence-based efficacy. Ann Burns Fire Disasters. 2013 Dec 31;26(4):205-212.

[8] Khatri KA, Mahoney DL, McCartney MJ. Laser scar revision：A review. J Cosmet Laser Ther. 2011;13(2):54-62

[9] Ozog DM, Liu A, Chaffins ML, et al. Evaluation of Clinical Results，Histological Architecture, and Collagen Expression Following Treatment of Mature Burn Scars With a Fractional Carbon Dioxide Laser. JAMA Dermatology. 2013;149(1): 50-57.

[10] Son D, Harijan A. Overview of Surgical Scar Prevention and Management. J Korean Med Sci. 2014;29(6):751-757.

[11] Ren HT, Hu H, Li Y, et al. Endostatin inhibits hypertrophic scarring in a rabbit ear model. J Zhejiang Univ Sci B. 2013; 14(3):224-230.

[12] Gauglitz GG, Korting HC, Pavicic T, et al. Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies. Molecular Medicine. 2011; 17(1-2):113-125.

[13] 李曾慧平,冯蓓蓓,李奎成,等.烧伤后增生性瘢痕压力治疗及相关研究[J].中华烧伤杂志,2010,26(6):411-415.

[14] Huang D, Liu Y, Huang Y, et al.Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts. Connect Tissue Res. 2014;55(5-6):391-396.

[15] Costa AM, Peyrol S, Pôrto LC,et al.Mechanical forces induce scar remodeling, Study in non-pressure-treated versus pressure-treated hypertrophic scars. Am J Pathol. 1999; 155(5): 1671-1679.

[16] Brissett AE, Sherris DA. Scar contractures，hypertrophic scars, and keloids. Facial Plast Surg. 2001;17(4):263-272.

[17] 李俊男,刘流.聚硅酮在瘢痕防治中的作用机制和应用[J].医学综述,2009,15(18):2760-2762.

[18] 陈灵,农晓琳,陈翔,等.硅酮凝胶喷雾剂局部喷涂对兔耳增生性瘢痕影响的实验研究[J].中国临床新医学,2012,05(5):393-396.

[19] 李曾慧平,刘颂文,励建安,等.压力治疗及硅酮敷料治疗对增生性瘢痕疗效的短期研究[J].中华物理医学与康复杂志,2004,26(8): 462-465.

[20] Manuskiatti W, Fitzpatrick RE. Treatment response of keloidal and hypertrophic sternotomy scars：comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol. 2002;138(9):1149-1155.

[21] Manstein D, Herron GS, Sink RK, et al. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34(5):426-438.

[22] Kunishige JH, Katz TM, Goldberg LH, et al. Fractional photothermolysis for the treatment of surgical scars. Dermatol Surg. 2010; 36(4):538-541.

[23] 谭军,李高峰,吴东辉,等.点阵激光治疗面颈部浅表性瘢痕疗效观察[J].中国美容医学,2008,17(10):1508-1509.

[24] 鲍卫汉,徐少骏.激素治疗瘢痕的机理研究[J].中华外科杂志, 2000, 38(5):378-381.

[25] Reish RG，Eriksson E. Scar treatments：preclinical and clinical studies. J Am Coll Surg. 2008;206(4):719-730.

[26] 赵贤忠,孙记燕,葛永亮,等.瘢痕移除后瘢痕皮回植原位皮肤再生治疗增生性瘢痕[J].中国组织工程研究与临床康复, 2010, 14(18): 3327-3330.

[27] 刘海兵,唐丹,曹海燕,等.温哥华瘢痕量表的信度研究[J].中国康复医学杂志,2006,21(3):240-242.

[28] Tyack Z, Simons M, Spinks A, et al. A systematic review of the quality of burn scar rating scales for clinical and research use. Burns. 2012;38(1):6-18.

[29] Oliveira GV, Chinkes D, Mitchell C, et al. Objective assessment of burn scar vascularity，erythema,pliability，thickness, and planimety. Dermatologic surgery. 2005;31(1): 48-58.

[30] Sullivan T, Smith J, Kermode J, et al. Rating the burn scar. J Burn Care Rehabil. 1990;11(3):256-260.

[31] Nedelec B，Shankowsky HA, Tredget EE. Rating the resolving hypertrophic scar: comparison of the Vancouver Scar Scale and scar volume. J Burn Care Rehabil. 2000; 21(3):205-212.

[32] Nedelec B, Correa JA, Rachelska G, et al. Quantitative Measurement of Hypertrophic Scar: Interrater Reliability and Concurrent Validity. J Burn Care Res. 2008;29(3):501-511.

[33] Fearmonti R, Bond J, Erdmann D, et al. A Review of Scar Scales and Scar Measuring Devices. Eplasty. 2010;10: 354-363.

[34] Vercelli S, Ferriero G, Sartorio F, et al. How to assess postsurgical scars: A review of outcome measures. Disabil Rehabil. 2009; 31(25):2055-2063.

[35] MB vdW, WE T, MC B. Rasch analysis of the Patient and Observer Scar Assessment Scale(POSAS)in burn scars. Qual Life Res. 2012;21(1):13-23.

[36] Brusselaers N, Pirayesh A, Hoeksema H, et al. Burn Scar Assessment: A Systematic Review of Different Scar Scales. J Surg Res. 2010;164(1): 115-123.

[37] Cheng W, Saing H, Zhou H, et al. Ultrasound assessment of scald scars in Asian children receiving pressure garment therapy. J Pediatr Surg. 2001;36(3):466-469.

[38] 陈惠平,张余光,钱云良等.瘢痕的临床评估[J].中国美容医学, 2004,13(6):751-752.

[39] 杨传晶.增生性瘢痕成熟度定量测量仪的色度与硬度开发[D].中山大学, 2010.