Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (5): 902-906.doi: 10.3969/j.issn.2095-4344.2013.05.021
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徐泽鹏,马腾飞,李凯扬
Received:
2012-07-08
Revised:
2012-07-29
Online:
2013-01-29
Published:
2013-01-29
Contact:
Li Kai-yang, Doctor, Professor, Department of Electronic Science and Technology, School of Physics, Wuhan University, Wuhan 430072, Hubei Province, China
lky@whu.edu.cn
About author:
Xu Ze-peng★, Master, Department of Electronic Science and Technology, School of Physics, Wuhan University, Wuhan 430072, Hubei Province, China
wdxzp1988@126.com
CLC Number:
徐泽鹏,马腾飞,李凯扬. Insight into the three-wavelength hepatic reserve function detection system[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(5): 902-906.
2.1 探头部分 本系统光源选择波长为660,805, 940 nm的LED,选择epitex公司的L660/805/940- 35B42,该LED将3个波长的LED封装到一个光源中,可以大大减少探头的体积,并保证每个LED被光电二极管接收范围一致。在人体信号的提取、处理过程中,会有比较多的干扰信号,因此系统选择了BB公司的光电传感器OPT101,其最大的优点是集成了前置放大滤波单元,光电二极管和互跨阻抗放大器在一片单片上的集成和结合可以消除分立设计中通常出现的问题,如漏电流误差,噪声交叉干扰和由于杂散电容引起的增益峰化,OPT101对于660,805,940 nm的光具有较高的灵敏性,可以将光信号有效的转换为电信号[12]。 2.2 外围电路部分 2.2.1 LED时序控制和驱动 系统利用NE555芯片和计数译码器CD4017组成的脉冲信号发生及分配电路作为LED的时序控制电路,产生频率50 Hz,占空比为1/6的脉冲,见图2。依次循环产生660 nm->暗光- >805 nm->暗光->940 nm->暗光。LED点亮和熄灭的工作时序,见图3。其中T1、T3、T5分别表示660,805,940 nm LED点亮时间,而T2、T4、T6表示暗光时间,所有时间均相等。"
4 结论与展望 本文对基于吲哚青绿排泄试验的肝储备功能检测系统的各个模块进行了详细介绍,对比实验验证效果良好。该系统可以无创、实时的提供吲哚青绿15 min滞留率以及血氧饱和度等人体信息,系统采用3波长LED照射手指,并利用光电传感器采集透过手指的光强,软件方面采用数字滤波器及自学习阈值法去除干扰信号。这种用于手指的便携式肝储备功能检测系统在医院和家庭的检测和监护中具有非常广阔的应用前景,进一步改进和完善之后,将与临床结合,完成该系统测量值的精确标定,以达到医学测量的精准度要求。 基金资助:武汉市“3551人才计划”项目资助(项目编号:武新管[2010]210号)。 作者贡献:第一作者进行实验设计,第一二作者共同实施,第三作者进行实验评估,第一作者收集、成文,第三作者审校,第一作者对文章负责。 利益冲突:课题未涉及任何厂家及相关雇主或其他经济组织直接或间接的经济或利益的赞助。 伦理要求:课题未涉及任何伦理学内容。 作者声明:文章为原创作品,数据准确,内容不涉及泄密,无一稿两投,无抄袭,无内容剽窃,无作者署名争议,无与他人课题以及专利技术的争执,内容真实,文责自负。"
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