Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (42): 6882-6888.doi: 10.3969/j.issn.2095-4344.2015.42.028

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Effects of hypothermic machine perfusion versus static cold storage of kidney allografts on transplant outcomes: a Meta-analysis

Hu Xiao-yan1, Wang Yan-feng1, Ye Qi-fa1, 2, Chen Zhi-quan1, Fan Xiao-li1, Guo Yi3, 4, Li Ning1   

  1. 1Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China; 2Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China; 3Department of Epidemiology, School of Public Health, Wuhan University, Wuhan 430071, Hubei Province, China; 4State Key Laboratory of Virology, Wuhan University, Wuhan 430071, Hubei Province, China
  • Online:2015-10-08 Published:2015-10-08
  • Contact: Ye Qi-fa, M.D., Professor, Chief physician, Doctoral supervisor, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China; Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
  • About author:Hu Xiao-yan, Studying for master’s degree, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
  • Supported by:

    the National Natural Science Foundation and Xinjiang Joint Project, No. U1403222; the Medical and Family Planning Research of Hubei Province, No. WJ2015MB037; the Fundamental Research Funds for the Central Universities, No. 2042015kf1015

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Abstract:

BACKGROUND: At present, there are a number of articles about hypothermic machine perfusion versus static cold storage of kidney allografts; however, the conclusions are various. Furthermore, due to the limitation of single sample size, there is a lack of objective evaluation on the merits and demerits of hypothermic machine perfusion.

OBJECTIVE: To compare the prognostic outcomes of hypothermic machine perfusion and static cold storage of kidney allografts.
METHODS: A computer-based search of PubMed, sinoMed, EMbase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), Wanfang and CNKI databases were searched from their establishment to March 4, 2015 to screen the randomized controlled trials (RCTs) about hypothermic machine perfusion versus static cold storage for kidney transplantation. Meanwhile, the references of included RCTs were also searched by hand. After study selection, RCTs screening, data extraction and quality assessment were conducted by two reviewers independently. Meta-analyses were performed by using the RevMan5.3.0 software. The quality of evidence was assessed by using the GRADEpro3.6 software.

RESULTS AND CONCLUSION: Six articles were included, involving 619 cases undergoing hypothermic machine perfusion and 620 cases undergoing static cold storage. The results of Meta-analyses showed that the incidence of primary graft non-function, incidence of delayed graft function of functional kidney allografts, and incidence of delayed graft function were significantly lower in the hypothermic machine perfusion group than the static cold storage group (P < 0.05 or 0.01). There were no differences in the 1-year recipient survival rate and 1-year allograft survival rate between the two groups (P > 0.05). These findings indicate that the hypothermic machine perfusion only can reduce the incidence of postoperative complications to maintain the function of kidney, but cannot improve the 1-year recipient survival rate and 1-year allograft survival rate. Hypothermic machine perfusion has no advantage on the long-term preservation of donor organ compared with the static cold storage. 
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Kidney, Kidney Transplantation, Organ Preservation, Organ Transplantation, Meta-Analysis