Correlation of survival time and C-reactive protein after artificial tracheal replacement in rabbits

doi:10.3969/j.issn.2095-4344.2014.05.011

Abstract

Abstract:

BACKGROUND:C-reactive protein has been shown to rapidly increase during the occurrence of inflammation and tissue injury, and can indicate the degree of inflammatory reaction.

OBJECTIVE: To analyze the correlation between survival time and C-reactive protein in rabbits after transplantation of polytetrafluoroethene artificial trachea with support ring.

METHODS: The cervical trachea of rabbits was replaced by polytetrafluoroethene artificial trachea with support ring. Survival time of the rabbit, and the changes in serum C-reactive protein at 1-7 days after transplantation were observed. Linear regression was used to assess the univariate association between serum C-reactive protein and survival time.

RESULTS AND CONCLUSION: The linear correlation was observed between changes of serum C-reactive protein and survival time in rabbits with artificial trachea replacement operation. C-reactive protein levels in rabbits with < 13 days of survival time were increased and positively associated with the number of days after transplantation. However, C-reactive protein levels in rabbits with > 13 days were decreased and negatively associated with the number of days after transplantation. In rabbits with positive correlation and negative correlation, the median survival time and 95% confidence interval (CI) were respectively 10 days (95%CI 8.614-11.386 days) and 27 days (95%CI 23.970-30.030 days). The survival rate in negative correlation group was significantly higher than positive correlation group (x² =29.364, P < 0.01). Results suggested that the prolonged survival time of rabbits after artificial trachea replacement operation was related to the decreased concentration of serum C-reactive protein.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: organ transplantation, trachea, C-reactive protein

CLC Number:

R318

Yao Jia, Li Xiao-jun, Cui Xiao-hai, Zhao Yang, Zhang Jing, Li Gang, Cao Pei-long. Correlation of survival time and C-reactive protein after artificial tracheal replacement in rabbits[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(5): 718-723.

Figures/Tables 3

References

[1] Steger V, Hampel M, Trick I, et al. Clinical tracheal replacement: transplantation, bioprostheses and artificial grafts. Expert Rev Med Devices. 2008;5(5):605-612.

[2] Baiguera S, D'innocenzo B, Macchiarini P. Current status of regenerative replacement of the airway. Expert Rev Respir Med. 2011;5(4):487-494.

[3] Grimmer JF, Herway S, Hawkins JA, et al. Long-term results of innominate artery reimplantation for tracheal compression. Arch Otolaryngol Head Neck Surg.2009;135(1):80-84.

[4] Doss AE, Dunn SS, Kucera KA, et al. Tracheal replacements: Part 2. ASAIO J.2007;53(5):631-639.

[5] Kucera KA, Doss AE, Dunn SS, et al. Tracheal replacements: part 1. ASAIO J.2007;53(4):497-505.

[6] Wang S, Shi H. Research progress of artificial tracheal prosthesis. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011; 25(3):365-368.

[7] Fishman JM, De Coppi P, Elliott MJ, et al. Airway tissue engineering. Expert Opin Biol Ther. 2011;11(12):1623- 1635.

[8] Asnaghi A, Macchiarini P, Mantero S.Tissue engineering toward organ replacement: a promising approach in airway transplant.Int J Artif Organs. 2009;32(11):763-758.

[9] Haag JC, Jungebluth P, Macchiarini P. Tracheal replacement for primary tracheal cancer. Curr Opin Otolaryngol Head Neck Surg. 2013;21(2):171-177.

[10] Grillo HC. Tracheal replacement. Ann Thorac Surg.1990; 49(6): 864-865.

[11] Neville WE, Bolanowski JP, Kotia GG. Clinical experience with the silicone tracheal prosthesis. J Thorac Cardiovasc Surg. 1990 ;99(4):604-612.

[12] Dulguerov P, Soccal P M, Bouayed S, et al. Tracheal replacement grafts: current options. Rev Med Suisse. 2011; 7(311):1924-1928.

[13] Fuchs JR, Nasseri BA, Vacanti JP. Tissue engineering: a 21st century solution to surgical reconstruction. Ann Thorac Surg. 2001;72(2):577-591.

[14] Sato T, Tao H, Araki M, et al.Replacement of the left main bronchus with a tissue-engineered prosthesis in a canine model.2008;86(2):422-428.

[15] Choi HS, Suh H, Lee JH, et al.A polyethylene glycol grafted bi-layered polyurethane scaffold: preliminary study of a new candidate prosthesis for repair of a partial tracheal defect. Eur Arch Otorhinolaryngol. 2008;265(7):809-816.

[16] Tillett W S, Francis T. Serological Reactions In Pneumonia with a Non-Protein Somatic Fraction Of Pneumococcus. J Exp Med.1930;52(4):561-571.

[17] Hurimann J, Thorbecke GJ, Hochwald GM. The liver as the site of C-reactive protein formation. J Exp Med. 1966; 123 (2):365-378.

[18] Eklund CM. Proinflammatory cytokines in CRP baseline regulation. Adv Clin Chem. 2009;48:111-136.

[19] Litvack ML, Palaniyar N. Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation. Innate Immun. 2010;16(3):191-200.

[20] Gabay C, Kushner I.Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448- 454.

[21] Zhang Y, Bunjhoo H, Xiong W, et al. Association between C-reactive protein concentration and chronic obstructive pulmonary disease: a systematic review and meta-analysis. J Int Med Res.2012;40(5):1629-1635.

[22] Wang CY, Hsieh MJ, Chiu YC, et al. Higher serum C-reactive protein concentration and hypoalbuminemia are poor prognostic indicators in patients with esophageal cancer undergoing radiotherapy. Radiother Oncol. 2009;92(2): 270-275

[23] Pine JK, Fusai K G, Young R, et al. Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas. Eur J Surg Oncol. 2009;35(6): 605-610.

[24] Karakiewicz PI, Hutterer GC, Trinh QD, et al. C-reactive protein is an informative predictor of renal cell carcinoma-specific mortality: a European study of 313 patients. Cancer.2007;110(6):1241-1247.

[25] Hefler LA, Concin N, Hofstetter G, et al. Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer. Cancer. 2007;110(6):1241-1247.

[26] Herishanu Y, Perry C, Braunstein R, et al. Early-mid treatment C-reactive protein level is a prognostic factor in aggressive non-Hodgkin's lymphoma. Eur J Haematol. 2007;79(2):150- 154.

[27] Zahlten-hinguranage A, Goldschmidt H, Cremer F W, et al. Preoperative elevation of serum C--reactive protein is predictive for prognosis in myeloma bone disease after surgery. Br J Cancer. 2006;95(7):782-787.

[28] Tartour E, Dorval T, Mosseri V, et al. Serum interleukin 6 and C-reactive protein levels correlate with resistance to IL-2 therapy and poor survival in melanoma patients. Br J Cancer. 1994;69(5):911-913.

[29] Hashimoto K, Ikeda Y, Korenaga D, et al. The impact of preoperative serum C-reactive protein on the prognosis of patients with hepatocellular carcinoma. Cancer.2005;103(9): 1856-1864.

[30] Zheng Z, Zhou L, Gao S, et al. Prognostic role of C-reactive protein in hepatocellular carcinoma: a systematic review and meta-analysis. Int J Med Sci. 2013;10(6):653-664.

[31] Ott LM, Weatherly RA, Detamore MS. Overview of tracheal tissue engineering: clinical need drives the laboratory approach. Ann Biomed Eng.2011;39(8):2091-2113.

[32] Kalathur M, Baiguera S, Macchiarini P. Translating tissue-engineered tracheal replacement from bench to bedside. Cell Mol Life Sci. 2010;67(24):4185-4196.

[33] Chen L, Shi H. [Current status and progress of tracheal substitute]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2012;29(3):593-596.

[34] Azorin JF, Bertin F, Martinod E, et al. Tracheal replacement with an aortic autograft. Eur J Cardiothorac Surg. 2006;29(2): 261-263.

[35] Grillo HC. Tracheal replacement: a critical review. Ann Thorac Surg. 2002;73(6):1995-2004.

[36] Makris D, Marquette CH. Tracheobronchial stenting and central airway replacement. Curr Opin Pulm Med. 2007; 13(4):278-283.

[37] Xu H, Shi H, Chen H. [Research progress of tracheal prosthesis in reconstructing trachea]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007;21(5):536-540.

[38] Liu W, Xiao P, Liang H, et al. Trachea repair and reconstruction with new composite artificial trachea transplantation.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi.2013;27(3):330-334.

[39] Martinod E, Seguin A, Radu D, et al. Advances in tracheal surgery: are we close to finding the ideal tracheal substitute?. Rev Mal Respir. 2010;27(6):554-564.

[40] Schultz P, Vautier D, Dupret A, et al. Replacement of the trachea using surgical reconstruction: current state of research. Ann Otolaryngol Chir Cervicofac. 2009;126(5-6): 272-277.

[41] Chander PM, Ali FM, Aher V.C-reactive protein a better indicator of inflammation after third molar extraction. Niger J Clin Pract. 2013;16(3):297-301.

[42] Clarke L. Centromeres of budding and fission yeasts. Trends Genet. 1990;6(5):150-154.

[43] Yousuf O, Mohanty BD, Martin SS, et al. High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link?.J Am Coll Cardiol. 2013;62(5): 397-408.

[44] Ramanathan ML, Mackay G, Platt J, et al.Impact of day 2 C-reactive protein on day 3 and 4 thresholds associated with infective complications following curative surgery for colorectal cancer. World J Surg.2013;37(11):2705-2710.

[45] Wysocki WM, Stasik Z, Darasz Z, et al. Preoperative radiotherapy does not alter pre- and early postoperative serum C-reactive protein and albumin concentrations in colorectal cancer patients.Contemp Oncol (Pozn). 2013; 17(2):161-164.

[46] Orati JA, Almeida P, Santos V,et al.Serum C-reactive protein concentrations in early abdominal and pulmonary sepsis.Revista brasileira de terapia intensiva. 2013;25(1): 6-11.

[47] Yildirim I, Hur E, Kokturk F.Inflammatory Markers: C-Reactive Protein, Erythrocyte Sedimentation Rate, and Leukocyte Count in Vitamin D Deficient Patients with and without Chronic Kidney Disease.Int J Endocrinol. 2013;2013:802165.

[48] Teramachi M, Okumnra N, Nakamura T, et al. Intratboracic tracheal reconstruction with a collagen-conjugated prosthesis: evaluation of theefficacy of omental wrapping. J Thorac Cardiovase Surg. 1997;l13:70l-711.

[49] Delaere PR. Tracheal transplantation. Curr Opin Pulm Med. 2012;18(4):313-320.

[50] 刘军,石文君,张苏宁.肺组织瓣包埋金属支架重建气管、食管的动物实验研究[J].中华医学杂志,2011,91(1):65-68.

[51] 纪子钊,陈刚,张苏宁,等.记忆合金材料弹力金属支架在犬肺组织瓣重建气管缺损中的应用[J].中国组织工程研究与临床康复, 2011, 15(51): 9549-9552.

[52] 张银合,赵凤瑞,刘德若,等.记忆合金网二期成形人工气管实验研究[J]. 中华胸心血管外科杂志,2004,20(2): 67-69.

[53] 赵俊刚,张苏宁,石文君,等.自体肺组织瓣内衬记忆合金支架替代长节段气管缺损:动物实验及临床观察[J].中国组织工程研究与临床康复,2008,12(22):4209-4212.

[54] Nakamura T, Ohmori K, Kanemaru S. Tissue-engineered airway and "in situ tissue engineering". Gen Thorac Cardiovasc Surg. 2011;59(2):91-97.

[55] Zhang F, Zhang W, Shi H. Research progress of decellularized matrix in tissue engineered trachea transplantation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013;27(2):223-226.

[56] He X, Fu W, Zheng J. Cell sources for trachea tissue engineering: past, present and future. Regen Med. 2012;7(6): 851-863.