Feasibility of preoperative ratio of C-reactive protein to albumin for assessing the prognosis of older adults with hip fracture undergoing arthroplasty or internal fixation

doi:10.3969/j.issn.2095-4344.1133

Abstract

Abstract:

BACKGROUND: Preliminary studies have shown that preoperative serum levels of C-reactive protein and albumin can predict the mortality in elderly patients with hip fracture within 1 year after surgery, but there has not been a report on the clinical value of combined evaluation.

OBJECTIVE: To investigate the effect of preoperative ratio of serum C-reactive protein to albumin on prognosis of elderly patients with hip fracture.

METHODS: The serum levels of C-reactive protein and albumin in 155 patients with hip fractures undergoing internal fixation or arthroplasty were detected, and the ratio of C-reactive protein/albumin was measured. According to the median value of 2.37, patients were divided into high ratio group and low ratio group. The relationship between C-reactive protein/albumin and clinical data was analyzed. The Kaplan-Meier method was used for survival analysis. The Cox risk model was used to analyze the prognostic factors of hip fracture in elderly patients.

RESULTS AND CONCLUSION: (1) Patients in the high ratio group were older, had higher C-reactive protein level, more chronic lung disease and American Society of Anesthesiologists grade III/IV ratio, and lower albumin level compared with the low ratio group (P < 0.05). (2) The mortality rate (20.65%) in the high ratio group was significantly higher than that in the low ratio group (11.84%) (χ²=7.053, P=0.008). (3) Age, American Society of Anesthesiologists classification and C-reactive protein/albumin ratio were independent risk factors for elderly patients with hip fracture. (4) In summary, the preoperative C-reactive protein/albumin ratio in elderly patients with hip fracture has a certain value in predicting the survival rate within 1 year after operation. High preoperative C-reactive protein/albumin ratio suggests poor prognosis.

Key words: hip fracture, C-reactive protein, elderly, tissue engineering

CLC Number:

R496|R683|R318

Lu Qilin, Cai Xianhua, Shang Ranran, Chen Yanzhao, Xie Wei, Chen Xiongwei, Wu Haiyang. Feasibility of preoperative ratio of C-reactive protein to albumin for assessing the prognosis of older adults with hip fracture undergoing arthroplasty or internal fixation[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(28): 4435-4439.

Figures/Tables 4

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