Biomechanical property and tracheal remodeling during tracheal anastomotic healing after tracheal suture with three different materials

doi:10.3969/j.issn.2095-4344.2013.03.016

Abstract

Abstract:

BACKGROUND: Researches have showed that the selection of trachea and bronchi anastomotic materials has different effects in the healing quality.
OBJECTIVE: To establish the rabbit tracheal reconstruction model with three different suture materials and to detect the relationship between biomechanical property and tracheal remodeling during the different phases of the rabbit wound healing.
METHODS: Eighteen New Zealand white rabbits were divided into three groups randomly, and the silk thread, dacron thread and synthetic absorption suture were used to establish tracheal reconstruction model.
RESULTS AND CONCLUSION: Tensile strength of anastomosis trachea: The tracheas anastomosed by three sutures were fractured close to the anastomotie stoma under external forces after 2 weeks; otherwise, the sutures were not torn. After 4 and 8 weeks, the tracheas were fractured in the part far away from anastomotie stoma, and no trachea was fractured on the anastomotie stoma. Bursting strength of anastomosis trachea: After 2, 4 and 8 weeks, three anastomotie stomas were burst from tracheal membranous. Collagen Ⅰ concentration: the collagen Ⅰconcentration in dacron thread group was lower than that in the other two groups (P < 0.05). There was no significant difference of collagen Ⅰ concentration after 4 and 8 weeks among three groups. It shows that the stability of the tracheal anastomosis will not be influenced by the suture material, but tracheal stenosis has certain differences after suture with different suture materials at various periods.

Key words: biomaterials, material mechanics and surface modification, rabbit trachea, three suture materials, type Ⅰ collagen concentration, provincial grants-supported paper, biomaterial photographs-containing paper

CLC Number:

R318

You Yong, Liang Ren-ji, Mo Liang. Biomechanical property and tracheal remodeling during tracheal anastomotic healing after tracheal suture with three different materials[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(3): 477-482.

Figures/Tables 5

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