Autologous peripheral blood stem cell transplantation for treatment of peripheral nerve injury

doi:10.3969/j.issn.2095-4344.2013.01.029

Abstract

Abstract:

BACKGROUND: Neural stem cells for treatment of peripheral nerve injury have been much reported. But few studies are reported regarding peripheral blood stem cells for treatment of peripheral nerve injury.
OBJECTIVE: To investigate the clinical application of autologous peripheral blood stem cells transplantation reinnervating denervated skeletal muscle in the treatment of peripheral nerve injury.
METHODS: Six patients received peripheral blood stem cells transplantation for treatment of peripheral nerve injury. At the same time, 10 controls received only anastomosis or nerve transplantation. All patients were intramuscularly administered mouse nerve growth factors one or two treatment courses. In addition, acupuncture, physical therapy, transcutaneous electrical stimulation and functional rehabilitation were also given.
RESULTS AND CONCLUSION: Two groups of patients were followed up over 6 months. The motor nerve and sensory nerve recovered better in patients who received peripheral blood stem cells transplantation than in patients who underwent simple neural anastomosis. These findings suggest that peripheral blood stem cells transplantation can reinnervate the distal denervated skeletal muscle after peripheral nerve injury.

Key words: stem cells, clinical practice of stem cells, peripheral nerve, neural transplantation, neural regeneration, stem cells, autologous peripheral blood stem cells

CLC Number:

R394.2

Jin Wen-hu, Wei Zai-rong, Sun Guang-feng,Tang Xiu-jun, Wang Da-li. Autologous peripheral blood stem cell transplantation for treatment of peripheral nerve injury[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(1): 181-185.

Figures/Tables 4

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