Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (10): 1615-1621.doi: 10.3969/j.issn.2095-4344.1884

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Research hotspots and progress of bone repair materials in tissue engineering

Wei Chenxu1, He Yiwen1, Wang Dan1, Hou Jingxia1, 2, Xie Hui1, 2, Yin Fangzhou1, 2, Chen Zhipeng1, 2, Li Weidong1, 2   

  1. 1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; 2Key Laboratory of Chinese Medicine Processing in Jiangsu Province, Nanjing 210023, Jiangsu Province, China
  • Received:2019-05-08 Revised:2019-05-22 Accepted:2019-07-05 Online:2020-04-08 Published:2020-02-18
  • Contact: Li Weidong, Researcher, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; Key Laboratory of Chinese Medicine Processing in Jiangsu Province, Nanjing 210023, Jiangsu Province, China
  • About author:Wei Chenxu, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81373970; Key Provincial Projects of Innovation and Entrepreneurship Training Program for College Students of Nanjing University of Chinese Medicine in 2018, No. 201810315021Z

Abstract:

BACKGROUND: With the improvement in medical level, the clinical demand for bone repair materials is gradually increasing, and the requirements are also getting more and more.

OBJECTIVE: To review the related research progress in the field of bone repair materials in recent years, to analyze the advantages and disadvantages of different materials, and to guide future development in this research field.

METHODS: A computer-based online search of CNKI, Wanfang, PubMed, Web of Science databases was performed to retrieve papers published during 1950-2019 with the search terms “tissue engineering, bone repair material, bone defect, natural bone material, bone graft replacement material, traditional Chinese medicine” in Chinese and English. A total of over 900 papers were retrieved, and 68 of them were included in the final analysis.

RESULTS AND CONCLUSION: In recent year, with the flourish development of bone tissue engineering, the research of bone tissue repair materials is in the ascendant. In addition to optimizing natural bone, a variety of bone graft substitute materials have been developed, for example, natural macromolecule materials, synthetic macromolecule materials, biomedical ceramics materials, biomedical metal materials, etc., but these materials have different properties. Although there are many bone repair materials at present, the ideal bone repair materials are few. Therefore, bone tissue repair and bone remodeling is still one of the urgent orthopedic problems to be solved in the clinic. In addition, the traditional Chinese medicine for bone repair, such as pyritum combined with modern bone repair materials, can effectively avoid some of the drawbacks of the current bone repair materials, thereby effectively treating bone defect diseases. This deserves in-depth investigation in the field of bone repair. 

Key words: tissue engineering, bone repair material, bone defect, natural bone material, allogeneic bone, artificial bone, bone graft replacement material, traditional Chinese medicine, pyritum

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