Basic research of tissue engineering in China: Bibliometric analysis

doi:10.3969/j.issn.2095-4344.1356

Abstract

Abstract:

BACKGROUND: The development of tissue engineering is of great social and economic significance. Understanding the current status of basic research in this field can provide reference for developing corresponding development strategies.

OBJECTIVE: To evaluate China's basic research current status in the field of tissue engineering.

METHODS: A computer-based online search of Pubmed was performed to retrieve basic research papers and top papers in the field of tissue engineering using search terms MESH terms AND free-text word. In the context of global background, China’s ability of basic research in the field of tissue engineering was analyzed based on the number of papers, the growth of the number of papers, the number and proportion of top papers. In addition, the number of papers was used to identify the global research hotspots in the field of tissue engineering.

RESULTS AND CONCLUSION: The top five countries in the field of tissue engineering were the United States, China, Japan, Germany and the United Kingdom. The total number of papers in this field published by Chinese scholars reached 17,031, second only to the United States. The compound annual growth rate of the number of papers was 19.9%, and the number of top papers was 195, ranking first and last among the top five countries, respectively. Eight Chinese institutions ranked top 30 in the number of papers in this field, with an average growth rate of 21.2%, far higher than that of all the top 30 institutions in the world (21.2% vs. 14.2, P < 0.001). However, Chinese institutions produced fewer top papers as compared to other top institutions, with the proportion of top papers significantly lower than that of the average level of the top 30 institutions (2.0% vs. 5.2%; P=0.002). There were five Chinese researchers whose total publications entered top 25 of the world. China's research in tissue engineering focuses on the areas of bone and cartilage, nerves, liver, skin, heart and eye tissue engineering, which is consistent with the global status. China's basic research in the field of tissue engineering ranks second in the world and expands rapidly in recent years. A number of academic institutions and individuals with great achievements have emerged. However, China's research quality in this field is relatively low as compared to other top institutions. It is suggested to guide researchers to pay more attention to the quality and transformation of research output, and to support the development of basic subjects such as material science to lay a good foundation for the development of tissue engineering in China.

Key words: tissue engineering, basic research, scientific paper, top paper, bibliometrics, medical device, innovation power, research hotspot

CLC Number:

Chen Juan, Wu Yidan, Zhang Ting, Yan Shu, Wang Tingting, Yang Yusheng, Ouyang Zhaolian. Basic research of tissue engineering in China: Bibliometric analysis[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(26): 4175-4180.

Figures/Tables 4

References

[1]冯刚.生物材料和再生医学的进展[J].现代经济信息, 2017,38(17): 377-379.

[2]王莉莎,贾红春.对临床康复、组织工程、再生医学学科定义以及相关内涵的认识与理解[J].中国组织工程研究与临床康复, 2007, 11(5):801-806.

[3]Langer R.Perspectives and challenges in tissue engineering and regenerative medicine. Adv Mater. 2009;21(32-33): 3235-3236.

[4]Atala A.Organ preservation, organ and cell transplantation, tissue engineering, and regenerative medicine: the terms may change, but the goals remain the same.Tissue Eng Part A. 2014; 20(3-4):445-446.

[5]Atala A.Tissue engineering and regenerative medicine: concepts for clinical application. Rejuvenation Res. 2004; 7(1):15-31.

[6]Liu W,Cao Y.Translational Research of Tissue Engineering in China.Tissue Eng Part A.2019;25(7-8):518-521.

[7]Caplan AI.Tissue Engineering: Then, Now and the Future. Tissue Eng Part A.2019;25(7-8):515-517.

[8]Milne CP,Kaitin KI.Challenge and Change at the Forefront of Regenerative Medicine. Clin Ther. 2018;40(7):1056-1059.

[9]Trommelmans L.The challenge of regenerative medicine. Hastings Cent Rep.2010;40(6):24-26.

[10]王正国.中国再生医学研究现状及展望[J].中国实用内科杂志, 2012,32(8):561-564.

[11]谭谦.再生医学与组织工程[J].医学研究生学报, 2011,24(2): 113-116.

[12]石颖.从国际顶级期刊的论文发表看广东省基础研究的水平与影响力[J].现代情报,2014,34(1):69-73.

[13]吴国雄,赵庚新.基于SCI论文的海峡两岸基础研究领域合作状况研究[J].中国基础科学,2013,15(2):36-41.

[14]李国栋.基于SCI论文产出的我国基础研究比较分析[J].北华航天工业学院学报,2010,20(4):21-23.

[15]陈娟,贾晓峰.我国医学基础理论研究水平、学科分布及趋势分析[J].中华医学科研管理杂志,2015,28(6): 453-456,460.

[16]Bornmann L,Daniel HD.Selecting scientific excellence through committee peer review - A citation analysis of publications previously published to approval or rejection of post-doctoral research fellowship applicants. Scientometrics. 2006;68(3):427-440.

[17]刘雪立.基于Web of Science和ESI数据库高被引论文的界定方法[J].中国科技期刊研究,2012,23(6): 975-978.

[18]池慧,欧阳昭连.中国医疗器械创新力发展报告[M].北京:科学出版社,2018.

[19]陈娟,张婷,欧阳昭连.我国医疗器械领域基础研究态势分析[J].医疗卫生装备,2019,40(1):69-72.

[20]孙晓北.组织工程及其我国发展问题对策研究[D].北京:中国协和医科大学,2009.

[21]陈兆莹.关于科技评价和科技评价改革的讨论[J].科学通报, 2018, 63(7):611-617.

[22]王海燕,张昕妍.我国科技评价体系改革的困境与对策[J].中国软科学,2018,33(4):10-17.

[23]Gu X, Ding F, Yang Y, et al. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Prog Neurobiol.2011;93(2):204-230.

[24]曹谊林.“耳郭软骨组织工程的研究进展”点评[J].中国眼耳鼻喉科杂志,2018,18(4):238-239.

[25]刘宁华,张天宇.耳郭软骨组织工程的研究进展[J].中国眼耳鼻喉科杂志,2018,18(4):234-237.

[26]Wu C,Zhou Y,Xu M,et al.Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials.2013;34(2):422-433.

[27]郝文丽,张平,吴训伟.组织工程皮肤的现状和展望[J].北京生物医学工程,2016,35(1):94-99.