Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (23): 3725-3733.doi: 10.12307/2021.046

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Bibliometric and visual analysis of international literature addressing ischemic stroke rehabilitation in recent 10 years

Huang Maomao, Hu Yue, Wang Binchuan, Zhang Chi, Xie Yujie, Wang Jianxiong, Wang Li, Xu Fangyuan   

  1. Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
  • Received:2020-04-16 Revised:2020-04-22 Accepted:2020-06-17 Online:2021-08-18 Published:2021-02-24
  • Contact: Xu Fangyuan, Master, Chief physician, Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
  • About author:Huang Maomao, Master, Physician, Department of Rehabilitation Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China
  • Supported by:
    the Project of Luzhou Municipal Science and Technology Department, No. 2019LZXNYDJ40 (to XFY)

Abstract: BACKGROUND: The ischemic stroke rehabilitation is the hotspot of the current research and much new cognition about it has been yielded in the past decade. so it is necessary to analyze the research regarding ischemic stroke rehabilitation qualitatively and quantitatively.
OBJECTIVE: To analyze publications of ischemic stroke rehabilitation in detail, to explore the main research forces and research status in the past decade, and to identify the current research hotspots and frontiers in this field. 
METHODS: The literatures on ischemic stroke rehabilitation published from 2010 to 2019 were retrieved in Web of Science (WoS) Core Collection (SCI-EXPANDED) on February 1, 2020. The global literatures and the first 100 articles with the most citations were analyzed based on WoS, involving the number of annual publications, authors, journals, institutions, countries/territories, funding, and citations. CiteSapace software was used to analyze global literature data and generate the visual atlas.
RESULTS AND CONCLUSION: A total of 3 098 literatures were obtained. The number of publications increased gradually from 175 in 2010 to 442 in 2017, with 367 in 2018 and 424 in 2019. The United States Department of Health Human Services financed the most studies. A total of 775 journals published literature in this field. Journal of Stroke Cerebrovascular Diseases was the journal with the largest number of publications (n=150), and the most cited journal was Stroke (5 999 citations). A total of 82 countries/territories, 4 015 institutions, and 14 676 authors published literature in this field. The top three countries and institutions with the most publications were the United States, China, Canada, and the University of Toronto, the Capital Medical University, and the University of Calgary. Kirton A and Bernhardt J were the most productive (n=25) and influential (903 citations) authors, respectively. The article of Feigin VL, et al. published in Lancet in 2014 was the most representative reference. Therapeutic-induced mechanism, corticospinal tract damage, cell-based therapy, consensus-based core recommendation, and motor function recovery are the basic frameworks in this field. The hotspots in this field mainly focus on patient individual treatment, gait, and cell-based therapy. Cost, nitric oxide synthase, functional MRI, long-term potentiation, neural regeneration and aphasia were the research frontiers. The rehabilitation of ischemic stroke showed great potential for development. We found that the development directions of this field mainly focus on the dysfunction of patients after ischemic stroke, specific effective rehabilitation interventions such as brain stimulation, cell therapy, and the effects of rehabilitation measures on neuroprotection, angiogenesis, hemodynamics and other specific mechanisms. Global scientific research cooperation is necessary to promote further development in the field of ischemic stroke rehabilitation.


Key words: ischemic stroke, rehabilitation, corticospinal tract, cell-based therapy, revascularization, neuroprotection, bibliometrics

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