Encapsulation of bone grafts using osteoinduction membrane, wire mesh or titanium mesh for repair of large-segmental bone defects

doi:10.3969/j.issn.2095-4344.0979

Abstract

Abstract:

BACKGROUND: Encapsulated bone graft is considered suitable for the treatment of large-segmental bone defects, but a large volume of autogenous cancellous bone tissues is needed and how to harvest cancellous bone is still an issue of clinical research.

OBJECTIVE: To investigate the effect of encapsulated bone graft by united procurement for repair of large-segmental bone defects.

METHODS: Clinical data from 21 cases of large-segmental bone defects treated with encapsulated autologous bone grafts were retrospectively analyzed. There were 15 males and 6 females, aged 15-69 years. Rich cancellous bone was harvested from the posterior iliac, proximal tibia or anterior iliac. Encapsulation of bone grafts using osteoinduction membrane, titanium mesh and wire mesh was conducted in 9, 7, and 5 cases, respectively. Bone healing, functional recovery of affected limbs, range of motion of adjacent joints and complications were observed during follow-up period.

RESULTS AND CONCLUSION: During the follow-up of 12-51 months, the average time for bone healing was 6 months for encapsulation using osteoinduction membrane, 6.29 months for encapsulation using titanium mesh, and 6.6 months for encapsulation using wire mesh. At the last follow-up, bone healing was excellent in 20 cases and good in 1 case; the functional recovery of the affected limb was excellent in 7 cases, good in 9 cases, fair in 4 cases and poor in 1 case, with the excellent and good rate of 76%. The range of motion of adjacent joints was excellent in 8 cases, good in 9 cases, fair in 3 cases and poor in 1 case, with the excellent and good rate of 81%. Complications in grafting sites were noted in 4 cases, and complications in harvesting sites were noted in 3 cases. These findings indicate that united harvesting of bone tissues can meet the requirement for a large volume of autogenous cancellous bone in the repair of large-segmental bone defects. Encapsulated bone graft has high healing rate, fast healing as well as few complications.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Bone Transplantation, Tissue Engineering

CLC Number:

R318

Han Xiao-fei, Liu Yu, Xu Ke-lin, Zhou Zi-hong, Gu San-jun, Yin Qu-dong. Encapsulation of bone grafts using osteoinduction membrane, wire mesh or titanium mesh for repair of large-segmental bone defects[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(30): 4782-4787.

Figures/Tables 5

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