Chinese Journal of Tissue Engineering Research ›› 2018, Vol. 22 ›› Issue (22): 3563-3568.doi: 10.3969/j.issn.2095-4344.0886

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Hemodynamic analysis of coronary stents in curved vessels

Tang Dan, Yuan Quan, Wang Zhi-chao, Zhu Hong-wei   

  1. Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Shandong University, Ministry of Education, Jinan 250061, Shandong Province, China
  • Received:2018-02-25 Online:2018-08-08 Published:2018-08-08
  • Contact: Yuan Quan, Professor, Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Shandong University, Ministry of Education, Jinan 250061, Shandong Province, China
  • About author:Tang Dan, Master candidate, Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Shandong University, Ministry of Education, Jinan 250061, Shandong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31170906

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Abstract:

BACKGROUND: As shown in the hemodynamic simulation test for stent implantation, the simulated blood vessels are generally designed to be straight but not curved. In order to make the simulation results reliable, the simulation model should be very close to the actual situation.

OBJECTIVE: To study the restenosis of the curved coronary artery, and to establish a model of curved blood vessels close to the actual situation of the human body so as to explain why the restenosis rate is relatively high for the curved coronary artery after stenting in clinic.
METHODS: The three-dimensional coronary stent model was established by Creo5 modeling software. Blood flow models (curved vessel-stent flow field) of curved coronary arteries (30°, 45°, 60°) and corresponding stents were established by means of Boolean calculation through the use of Ansys18.0 finite element simulation software. At the same time, a blood flow model (straight vessel-stent flow field) of the straight coronary artery under the same stent was established for comparison. After the study on fluid simulation, the proportion of wall shear stress (WSS) < 0.5 Pa and the flow resistance are compared in the two cases.

RESULTS AND CONCLUSION: (1) The WSS of the area with on stent in the two models was basically the same between 0.5-1.0 Pa, and the low WSS values were distributed in the lateral area of the stent strut whether in the straight vessel-stent flow field model or the curved vessel-stent flow field model. What’s more, a large low WSS area appeared at the end of the stent in the curved vessel-stent flow field model. (2) The area of WSS < 0.5 Pa accounted for 16.14% of the total area in the straight-stent flow field model, while this proportion was 25.21%, 28.65%, 26.63% in the curved vessel-stents (30°, 45°, 60°), respectively, indicating the rate of restenosis in the curved vessel stents were relatively high. (3) The distribution of WSS in all curved vessel-stent models were basically the same regardless of the curvature. (4) The flow resistance of the curved vessel-stent models (30°, 45°, 60°) [1.50, 1.82, 2.17 N•s2/(kg•m)] was higher than that of the straight vessel stent model [1.03 N•s2/(kg•m)]. To conclude, the rate of restenosis in the curved vessel stent is relatively higher than that in the straight vessel stent model.

 

Key words: Hemodynamics, Coronary Vessels, Coronary Stenosis, Tissue Engineering

CLC Number: