Artificial tiger bone and calfor applied in intervertebral fusion after degenerative lumbar spondylolisthesis

doi:10.3969/j.issn.2095-4344.0615

Abstract

Abstract:

BACKGROUND: Artificial tiger bone is a kind of tiger bone biomimetic drug, which is consistent with natural bone composition and pharmacological effects. It can effectively relieve pain and strengthen bones and muscles, which can also relieve back pain caused by osteoporosis.
OBJECTIVE: To investigate the therapeutic effect of artificial tiger bone in patients with degenerative lumbar spondylolisthesis undergoing internal fixation and interbody fusion procedure.
METHODS: Sixty cases of degenerative lumbar spondylolisthesis undergoing internal fixation and interbody fusion were randomly divided into two groups and treated with artificial tiger bone plus D-calfor (treatment group) or D-calfor alone (control group). Visual Analogue Scale, and Oswestry disability index at baseline, 7 days, 1, 6 and 12 months after treatment, and interbody fusion rate at 12 months after treatment were compared.
RESULTS AND CONCLUSION: All patients underwent internal fixation and interbody fusion procedure successfully and then treated with different drugs. No significant differences were observed in the two groups regarding the Visual Analogue Scale and Oswestry disability index scores at baseline. At 6 and 12 months after treatment, the scores in the treatment group were significantly superior to those in the control group (P < 0.05). Regarding the interbody fusion rate, the treatment group was slightly better than the control group (P > 0.05). To conclude, for patients with degenerative lumbar spondylolisthesis undergoing internal fixation and interbody fusion procedure, artificial tiger bone can alleviate pain and improve dysfunction, but cannot significantly increase interbody fusion rate.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Spondylolisthesis, Lumbar Vertebrae, Spinal Fusion, Tissue Engineering

CLC Number:

R318

Hu Wei, Kan Shunli, Cao Zegang, Jiang Zehua, Zhang Xueli, Zhu Rusen. Artificial tiger bone and calfor applied in intervertebral fusion after degenerative lumbar spondylolisthesis[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(36): 5741-5745.

Figures/Tables 4

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