Chinese Journal of Tissue Engineering Research ›› 2018, Vol. 22 ›› Issue (36): 5760-5765.doi: 10.3969/j.issn.2095-4344.0543

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Correlation between serum estradiol and testosterone levels and severity of early-stage knee osteoarthritis in patients

Huang Jie1, Bo Zhandong2, Liu Gang3, Luo Shixing4   

  1.  (1the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China; 2the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China; 3Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China; 4the Ninth Affiliated Hospital of Guangxi Medical University, Beihai 536000, Guangxi Zhuang Autonomous Region, China)
  • Received:2018-04-02 Online:2018-12-28 Published:2018-12-28
  • Contact: Luo Shixing, Professor, Chief physician, the Ninth Affiliated Hospital of Guangxi Medical University, Beihai 536000, Guangxi Zhuang Autonomous Region, China
  • About author:Huang Jie, Master, Physician, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81460345

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Abstract:

BACKGROUND: The incidence of knee osteoarthritis (KOA) in postmenopausal females has been found to be higher than that in the males of the same age. The age and gender distribution suggests that there exists certain correlation between KOA pathogenesis and sex hormone levels.
OBJECTIVE: To explore the correlation between sex hormone levels of the postmenopausal females and males of the same age, and early-stage KOA severity.
METHODS: Forty-four KOA patients and 29 healthy people were enrolled. The subjects were divided into two groups by sex, including postmenopausal female group (n=37) and male group age (n=36). Each group was further subdivided by Kellgren-Lawrence K-L grading system, including subgroups of K-L 0, K-L I and K-L II. The serum estradiol and testosterone levels in each subgroup were detected by electrochemical luminescence method, and its association with K-L grade was analyzed.
RESULTS AND CONCLUSION: In the postmenopausal female KOA patients, the serum estradiol level showed no significant difference between K-L 0 and K-L I subgroups (P > 0.05), the level in the K-L 0 and K-L I subgroups showed significant difference compared with the K-L II subgroup (P < 0.05). The serum testosterone level showed no significant difference among groups in the postmenopausal female KOA patients (P > 0.05). The KOA severity showed a negative correlation with the serum estradiol level (rs=-0.709, P < 0.05) but no correlation with the serum testosterone (P > 0.05). In the male KOA patients, the serum estradiol and testosterone levels showed no significant difference between K-L 0 and K-L I subgroups (P > 0.05), the levels in the K-L 0 and K-L I subgroups showed significant difference compared with the K-L II subgroup (P < 0.05). The KOA severity in male KOA patients showed a negative correlation with the serum estradiol level (rs=-0.476,  P < 0.05) and serum testosterone level (rs=-0.418, P < 0.05). These results indicate that the severity of early-stage KOA shows a negative correlation with the serum estradiol level in the postmenopausal female patients and a negative correlation with the serum estradiol and testosterone levels in the males of the same age.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoarthritis, Knee, Estradiol, Testosterone, Tissue Engineering

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