Predictive analysis of severity of hip arthritis using platelet-to-lymphocyte ratio: study protocol for a cross-sectional study and preliminary results

doi:10.3969/j.issn.2095-4344.0323

Abstract

Abstract:

BACKGROUND: Inflammatory changes play an important role in the pathogenesis of hip arthritis. However, there are currently no available effective inflammatory markers for the prediction of the severity of hip arthritis. Platelet-to-lymphocyte ratio (PLR) has been shown to be correlated with the severity of rheumatoid arthritis, psoriatic arthritis, and colon cancer.

OBJECTIVE: This study hypothesizes that PLR is correlated with the severity of hip arthritis and it can be used as a marker for evaluating the severity of hip arthritis.

METHODS: This study will include 260 patients with hip arthritis from the wards of Yantai Affiliated Hospital of Binzhou Medical University, China. These patients will consist of 130 patients with mild and moderate hip arthritis (Kellgren-Lawrence Grading Scale grade 1-2; mild and moderate hip arthritis group) and 130 patients with severe hip arthritis (Kellgren-Lawrence Grading Scale grade 3-4; severe hip arthritis group). At the same time, this study will include 130 healthy controls (control group). On the day of admission, patient’s clinical data will be collected, and blood biochemistry test and hip X-ray examination will be also performed. The primary outcome measure will be PLR. The secondary outcome measures are platelet count; lymphocyte count; X-ray morphology of the hip; Logistic regression analysis results of risk factors for the severity of hip arthritis; area under the ROC curve, cut-off value, sensitivity, and specificity of PLR in the prediction of the severity of hip arthritis. Study design has been completed at the time of submission. A pilot study involving 182 patients with hip arthritis, consisting of 98 patients with mild and moderate hip arthritis and 84 patients with severe hip arthritis, was performed between January 2014 and June 2017 at Yantai Affiliated Hospital of Binzhou Medical University. Logistic regression analysis of this pilot study revealed that diabetes, age, increased body mass index, and increased PLR were associated with aggravation of hip arthritis and were also the independent risk factors of this disorder. The study was approved by the Ethics Committee of the Yantai Affiliated Hospital of Binzhou Medical University in June 2018 (approval No. 20180601001). The study will be performed in accordance with the relevant laws and regulations of the Declaration of Helsinki. All the participants will be fully informed of the study protocol and experimental process, and provide written informed consent with the premise of fully understanding the treatment plan. This study was designed in April 2018. Patient recruitment and data collection will be initialized in October 2018, and completed in March 2019. Data analysis will be conducted in April 2019. The study will be completed in May 2019. The results of this study will be disseminated in peer-reviewed journals or presented at scientific meetings. This trial was registered in the Chinese Clinical Trial Registry with registration No. ChiCTR1800016820 (protocol version 1.0).

DISCUSSION: This study will indicate the correlation between PLR and the severity of hip arthritis; PLR has very high severity, specificity, and accuracy in the prediction of the severity of hip arthritis; the optimal cut-off value of PLR in the prediction of the severity of hip arthritis based on the ROC curve.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Tissue Engineering, Hip Joint, Blood Platelets, Lymphocytes

CLC Number:

R318

Jiao Xiu, Zhu Ai-qing. Predictive analysis of severity of hip arthritis using platelet-to-lymphocyte ratio: study protocol for a cross-sectional study and preliminary results[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(23): 3687-3691.

Figures/Tables 2

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