Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4367-4370.doi: 10.3969/j.issn.1673-8225.2012.23.035

Previous Articles    

Changes in cellular growth factor levels in cerebrospinal fluid of autism patients before and after human umbilical cord blood mononuclear cell transplantation

Li Qiang1, Lü Yong-tao1, Huan Ying1, Liu Min1, Ge Ru-cun1, Chen Xing-wang1, Qi Hong-Shun1, Gao Bao-Feng1, Hu Xiang2, An Lei2   

  1. 1Department of Stem Cells and Regeneration Medicine, Shandong Hospital of Communication, Jinan 250031, Shandong Province, China;
    2Shenzhen Beike Biotechnology Co.,Ltd., Shenzhen 518057, Guangdong Province, China
  • Received:2012-01-03 Revised:2012-03-25 Online:2012-06-03 Published:2013-11-06
  • About author:Li Qiang★, Master, Associate chief physician, Department of Stem Cells and Regeneration Medicine, Shandong Hospital of Communication, Jinan 250031, Shandong Province, China Liqiang9651@yahoo.com.cn

PDF

444

Abstract:

BACKGROUND: Studies have demonstrated that umbilical cord blood mononuclear cells exhibit some effects in treatment of autism.
OBJECTIVE: To detect levels of nerve growth factor (NGF), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in cerebrospinal fluid of autism patients treated with umbilical cord blood mononuclear cells.
METHODS: A total of 30 autism children received treatment by injection of human umbilical cord blood mononuclear cells via lumbar puncture subarachnoid cavity, once a week, for three times totally.
RESULTS AND CONCLUSION: The levels of nerve growth factors were significantly greater at 1 week after the second treatment than pretreatment and 1 week after the first treatment (P < 0.05). The levels of vascular endothelial growth factors and basic fibroblast growth factors were slightly, but not significantly, higher at 1 week after the second treatment than pretreatment and at 1 week after the first treatment (P > 0.05). Results suggest that the levels of nerve growth factors in cerebrospinal fluid were significantly increased in autism children who received treatment of umbilical cord blood mononuclear cells, however, the levels of vascular endothelial growth factors and basic fibroblast growth factors were not influenced significantly.

CLC Number: