Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4290-4295.doi: 10.3969/j.issn.1673-8225.2012.23.022

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Effect evaluation of autologous bone marrow mesenchymal stem cell transplantation on motor function in children with cerebral palsy

Liu Yan-song1,2, Wang Xiao-dong2, Yang Jing2, Hua Rong-rong2, Cheng Hong-bin2,3, Liu Ya-fei2, An Yi-hua2,3   

  1. 1General Hospital of Chinese People’s Armed Police Forces Base, Liaoning Medical University, Beijing 100039, China;
    2Department of Stem Cell Transplantation, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China;
    Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2012-04-01 Revised:2012-04-21 Online:2012-06-03 Published:2013-11-06
  • Contact: An Yi-hua, M.D., Chief physician, Department of Stem Cell Transplantation, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China; Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China riveran@163.com
  • About author:Liu Yan-song★, Studying for master’s degree, General Hospital of Chinese People’s Armed Police Forces Base, Liaoning Medical University, Beijing 100039, China; Department of Stem Cell Transplantation, General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China liuyansong77@163.com

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Abstract:

BACKGROUND: Cerebral palsy is described as a group of permanent disorders affecting motor development and posture, resulting in activity limitation. Although there are many kinds of functional therapy programs for cerebral palsy, their effects are limited. Stem cell based therapy, a new prospective therapy for central nervous system disorders, has the potential to repair and replace damaged brain tissue, and alleviate neurological deficits and motor function in cerebral palsy.
OBJECTIVE: Using Gross Motor Function Measure-88 (GMFM88) and Fine Motor Function Measure-45 (FMFM45) scale to evaluate the effect of autologous bone marrow mesenchymal stem cell transplantation on motor function in children with cerebral palsy.
METHODS: Twenty cerebral palsy children received autologous bone marrow mesenchymal stem cell transplantation and their motor functions were measured using GMFM88 scale and FMFM45 at baseline (the day before treatment) and 1, 3 and 6 months after treatment.
RESULTS AND CONCLUSION: Seventeen subjects successfully accomplished the clinical study. Results of statistical analysis by SPSS13.0 software showed that (1) The A, B, C functional area scores and total score of GMFM88 increased significantly at 1, 3 and 6 months after bone marrow mesenchymal stem cell transplantation than that at baseline (P < 0.05). (2) The B, C functional area scores and total score of FMFM45 increased significantly at 1, 3 and 6 months after bone marrow mesenchymal stem cell transplantation than that at baseline (P < 0.05). During the present study period, no events had happened. Bone marrow mesenchymal stem cell transplantation is a safe, effective and feasible method to treat cerebral palsy patients. The gross and fine motor function was most rapidly improved in 1 month after the therapy and it could be continuously improved within 6 months after the therapy.

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