Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4296-4300.doi: 10.3969/j.issn.1673-8225.2012.23.023

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Effects of stem cells transplantation on cardiac electrical activity

Guo Yi-hong, Zhang Xiao-gang   

  1. Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2011-10-13 Revised:2011-11-26 Online:2012-06-03 Published:2013-11-06
  • Contact: Zhang Xiao-gang, M.D., Professor, Master’s supervisor, Chief physician, Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China zxg0233@sina.com
  • About author:Guo Yi-hong★, Studying for master’s degree, Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China gyh4268@163.com

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Abstract:

BACKGROUND: Myocardial ion channel is one of the most important electrophysiological characteristics. But the changes in ion channels during the process of stem cells differentiation into cardiac cells and the impact on the electrophysiological properties of myocardial tissue remain unclear.
OBJECTIVE: To summarize the effects of stem cells transplantation on cardiac electrical activity.
METHODS: VIP database, PubMed database and SpringerLink database (2000-01/2011-05) were used to search the related articles about the effect of stem cells transplantation on cardiac electrical activity. The key words were “bone marrow mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, cardiac electrical activity, ion channels” in English and in Chinese.
RESULTS AND CONCLUSION: A total of 21 articles were included to review. The life threatening arrhythmia caused by stem cells transplantation has not been observed in a larger amount of clinical experiments at home or abroad, but some cardiac electrical activities and ion channel dynamics were changed after stem cells transplantation, the effects of stem cells transplantation on cardiac electrical activity should not be underestimated. The induced pluripotent stem cells can not only differentiate into myocardial cells, but also have the similar electrical activities with them. Therefore, it must be wildly studied and applied in the regenerative treatment of damaged myocardium.

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