Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4301-4305.doi: 10.3969/j.issn.1673-8225.2012.23.024

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Research and prospects of stem cells transplantation for the treatment of Alzheimer’s disease

Yu Cheng-cheng1, 2, 3, Zhang Bin2, 3, Chen Hu2, 3   

  1. 1Chinese PLA General Hospital, Beijing 100853, China;
    2Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences, Beijing 100071, China;
    3Cell and Gene Therapy Center of Academy of Military Medical Sciences, Beijing 100071, China
  • Received:2011-09-01 Revised:2011-10-20 Online:2012-06-03 Published:2013-11-06
  • Contact: Chen Hu, M.D., Chief physician, Professor, Zhang Bin, M.D., Associate researcher, Associate professor, Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences, Beijing 100071, China; Cell and Gene Therapy Center of Academy of Military Medical Sciences, Beijing 100071, China chenhu217@yahoo.com.cn; zb307ctc@163.com
  • About author:Chinese PLA General Hospital and Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital to Academy of Military Medical Sciences were considered as co-first institutional affiliation.

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Abstract:

BACKGROUND: Neural stem cells (NSCs) and bone marrow-derived mesenchsymal stem cells transplantation would alleviate the symptoms of Alzheimer’s disease patients and therefore shows the potential to treat Alzheimer’s disease.
OBJECTIVE: To review the research development of stem cells therapy for Alzheimer's disease, and to discusses its potential applications.
METHODS: The articles about stem cells transplantation for the treatment of Alzheimer's disease were retrieved in CNKI database and PubMed database from January 1981 to August 2011. The index words in titles and abstracts were “Alzheimer’s disease, stem cells, mesenchymal stem cells, transplantation”. The articles related to stem cells transplantation for the treatment of Alzheimer's disease and those which were recently published in famous Scholarly Journals in the same field were selected. At last, we got two hundred and forty-one theses. According to the inclusion criteria, 28 documents were finally selected.
RESULTS AND CONCLUSION: Understanding of the pathological changes and pathogenesis of Alzheimer's disease would be helpful to select sensitive biological markers and carry out effective preventions and treatments for Alzheimer's disease. Mitochondrial DNA changes of oxygen stress and the immune responses in Alzheimer's disease played a key role in the pathological process of Alzheimer's disease, and maybe have a good synergistic effect. The mechanism research regarding stem cells transplantation for treatment of Alzheimer's disease can guide the clinical applications.

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