Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4306-4309.doi: 10.3969/j.issn.1673-8225.2012.23.025

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Research progress of allogeneic bone marrow mesenchymal stem cells

Wang Hong-bin   

  1. Department of Surgical System, the Third Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
  • Received:2012-02-28 Revised:2012-05-11 Online:2012-06-03 Published:2013-11-06
  • About author:Wang Hong-bin, Associate chief physician, Department of Surgical System, the Third Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China 470337561@qq.com

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Abstract:

BACKGROUND: Autologous bone marrow mesenchymal stem cells transplantation is a new method in recent years for the treatment of articular cartilage defects. However, in the clinic, the autologous bone marrow mesenchymal stem cells cannot be used to repair the acute osteochondral defect in a short time, and allogeneic bone marrow mesenchymal stem cells can be in advance prepared for the application.
OBJECTIVE: To symmetrically analyze the immunomodulation activity and inhibition studies of allogeneic bone marrow mesenchymal stem cells.
METHODS: The PubMed database and Wanfang database from 1990 to 2009 were used to search the articles describing to the immunomodulation activity and inhibition studies of allogeneic bone marrow mesenchymal stem cells by the first author with the key words of “bone mesenchymal stem cells, immunomodulation activity, immunosuppression” in English and Chinese.
RESULTS AND CONCLUSION: Although the transplantation of allogeneic cells may be attacked by the immune system, bone marrow mesenchymal stem cell is an exception, as it is the regulatory T cell that can suppress the immune response. Bone marrow mesenchymal stem cells can inhibit the T cells, B cells, natural killer cells and antigen presenting cells. Bone marrow mesenchymal stem cells are the tissue engineering cell group that isolated from the bone marrow; it has the immunosuppression related marks, and can inhibit the proliferation of allogeneic T cells in vitro, so the bone marrow mesenchymal stem cells can be used for allogeneic cell therapy. Bone marrow mesenchymal stem cells provide a new method for the repair of articular cartilage defects in the clinic by allogeneic bone marrow mesenchymal stem cells.

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