Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (8): 1193-1199.doi: 10.12307/2023.953
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Zhao Garida, Ren Yizhong, Han Changxu, Kong Lingyue, Jia Yanbo
Received:
2022-09-19
Accepted:
2022-12-26
Online:
2024-03-18
Published:
2023-07-18
Contact:
Jia Yanbo, MD, Associate chief physician, Associate professor, Master’s supervisor, Sports Medicine Center, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
About author:
Zhao Garida, MD, Physician, Sports Medicine Center, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
Ren Yizhong, MD, Chief physician, Professor, Master’s supervisor, Sports Medicine Center, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
Supported by:
CLC Number:
Zhao Garida, Ren Yizhong, Han Changxu, Kong Lingyue, Jia Yanbo. Mechanism of Mongolian Medicine Erden-uril on osteoarthritis in rats[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(8): 1193-1199.
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给药2周后,与对照组相比,低、高剂量组大鼠血清中肿瘤坏死因子α、白细胞介素6水平均显著降低(P < 0.05,P < 0.01,P < 0.001),总胆固醇、三酰甘油水平均显著升高(P < 0.05,P < 0.01,P < 0.001),其中以高剂量组变化更显著。给药4周后,与对照组相比,低、高剂量组大鼠血清中肿瘤坏死因子α、白细胞介素6水平均显著降低(P < 0.01,P < 0.001),总胆固醇、三酰甘油水平均显著升高(P < 0.01,P < 0.001),其中以高剂量组改善更显著。 2.4 各组大鼠膝关节软骨结构变化 各组大鼠膝关节软骨组织苏木精-伊红染色结果,见图5。对照组大鼠膝关节软骨组织表层有较大缺损区,组织结构不明,炎症细胞浸润严重。低剂量组给药2 周后大鼠膝关节软骨表面粗糙,细胞排列紊乱,软骨结构改善不明显;给药4 周后大鼠膝关节软骨炎性细胞减少,结构有所恢复。高剂量组给药2 周后大鼠膝关节软骨组织结构较清晰,炎症明显减轻;给药4 周后大鼠膝关节软骨组织结构更清晰。"
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