Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (4): 609-614.doi: 10.12307/2023.897

Previous Articles     Next Articles

Signaling pathways in the mechanism underlying active ingredients of Chinese medicine in the treatment of osteoarthritis

Liu Luxing1, Di Mingyuan2, Yang Qiang3   

  1. 1Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; 2Tianjin Medical University, Tianjin 300070, China; 3Department of Spine Surgery, Tianjin Hospital, Tianjin 300210, China
  • Received:2022-12-05 Accepted:2023-01-13 Online:2024-02-08 Published:2023-07-14
  • Contact: Yang Qiang, MD, Chief physician, Department of Spine Surgery, Tianjin Hospital, Tianjin 300210, China
  • About author:Liu Luxing, Master candidate, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • Supported by:
    National Natural Science Foundation of China (General Program), No. 82072435 (to YQ)

Abstract: BACKGROUND: Osteoarthritis is a chronic degenerative disease of skeletal muscle, and the incidence of osteoarthritis is increasing yearly, but its pathogenesis is not clear. The commonly used drugs for osteoarthritis include non-steroidal anti-inflammatory drugs and glucocorticoid. Adverse drug reactions to these drugs can reduce patient compliance and ultimately affect the efficacy of treatment. Active ingredients in Chinese medicine are closely scrutinized for their safety and other characteristics.
OBJECTIVE: Through reviewing the research progress in the effect of active ingredients of traditional Chinese medicine on osteoarthritis-related signaling pathways, to provide ideas and theoretical basis for the research, development, and application of new drugs in the prevention and treatment of osteoarthritis.
METHODS: CNKI, WanFang, VIP, PubMed, and GeenMedical were searched for relevant literature in the last 10 years. The key words were “OA, osteoarthritis, traditional Chinese medicine, active ingredients of traditional Chinese medicine, chondrocyte, inflammation, signal pathways, mechanism” in Chinese and English. We excluded the irrelevant repetitive and older literature, and finally included 63 articles for further review.
RESULTS AND CONCLUSION: The active ingredients of traditional Chinese medicine regulate the levels of inflammatory factors, promote the proliferation and differentiation of chondrocytes, regulate the apoptosis of chondrocytes, and delay the degeneration of chondrocytes through Wnt/β-catenin, NK-ΚB, P38 MAPK, PI3K/AKT, JAK2/STAT3 and other signaling pathways, thus slowing the progression of osteoarthritis.

Key words: traditional Chinese medicine, active ingredient, osteoarthritis, signal pathway, mechanism of action, research progress

CLC Number: