中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (19): 3606-3610.doi: 10.3969/j.issn.1673-8225.2012.19.037

• 干细胞学术探讨 stem cell academic discussion • 上一篇    

骨关节炎患者骨髓干细胞特征及治疗进展*★◆

张  帆，王  友   

  1. 上海交通大学医学院附属第九人民医院骨科，上海市骨科内植物重点实验室，上海市200011
     
  • 收稿日期:2012-02-08 修回日期:2012-03-12 出版日期:2012-05-06 发布日期:2012-05-06
  • 通讯作者: 王友，男，主任医师，教授。上海交通大学医学院附属第九人民医院骨科，上海市骨科内植物重点实验室，上海市 200011 drwangyou@163.com
  • 作者简介:张帆★，男，1981年生，江苏省徐州市人，上海交通大学医学院在读硕士，医师。shevagoal@163.com
  • 基金资助:

    上海教委重点学科建设基金(J50206)资助。

Characterization of bone marrow mesenchymal stem cells and research progress in treatment of osteoarthritis patients 

Zhang Fan, Wang You   

  1. Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Received:2012-02-08 Revised:2012-03-12 Online:2012-05-06 Published:2012-05-06
  • Contact: Wang You, Chief physician, Professor, Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China drwangyou@163.com
  • About author:Zhang Fan★, Studying for master’s degree, Physician, Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China shevagoal@163.com
  • Supported by:

    Key Subjects Construction Foundation of Education Commission of Shanghai, No.J50206*

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摘要：

背景：目前的研究对于骨髓间充质干细胞的基本特征、提取分离方法及与其他来源间充质干细胞的比较已有较成熟的结论。
目的：总结骨关节炎患者骨髓干细胞基本特征及治疗进展。
方法：由第一作者用计算机检索PubMed数据库，检索词分别为“MSC，knee"，语言设定为英文。从间充质干细胞的基本特征，及其在临床应用进展等2方面进行总结，对骨髓间充质干细胞治疗软骨缺损的基本技术，治疗进展等方面进行总结。共检索到93篇文章，按纳入和排除标准对文献进行筛选，共纳入44篇文章。
结果与结论：在细胞来源方面，老年者干细胞的分化潜能下降，滑液及骨髓来源的间充质干细胞，其成软骨能力要远优于肌肉及脂肪组织来源的间充质干细胞。对于临床应用干细胞治疗膝关节软骨缺损等方面，三维支架及无支架的骨髓干细胞植入方法，关节腔内间充质干细胞的注射，自体骨移植等治疗技术已广泛应用于临床并都显示出一定的疗效，但具体治疗方法仍需进一步研究。
 

关键词: 骨关节炎, 膝关节, 骨髓间充质干细胞, 软骨缺损, 治疗

Abstract:

BACKGROUND: The basic characteristics and isolation method of bone marrow mesenchymal stem cells as well as the comparison with mesenchymal stem cells from other sources have been well studied.
OBJECTIVE: To summarize the basic characteristics of bone marrow mesenchymal stem cells and the research progress in treatment of osteoarthritis patients.
METHODS: A computer-based online retrieval of PubMed database was performed by the first author with the key words “MSC, knee” in English. The basic characteristics of mesenchymal stem cells and research progress in clinical treatment have been summarized. In addition, the technique of bone marrow mesenchymal stem cells used for treatment of cartilage defects and treatment progress were also summarized. A total of 93 papers were retrieved. According to inclusion and exclusion criteria, 44 papers were included in the final analysis.
RESULTS AND CONCLUSIONS: Mesenchymal stem cells from old people exhibit decreased differentiation potential. Synovia- and bone marrow-derived mesenchymal stem cells exhibit far better chondrogenic ability than muscle- and adipose-derived mesenchymal stem cells. The techniques including bone marrow mesenchymal stem cells transplantation with or without three-dimensional scaffold, intra-articular injection of mesenchymal stem cells, and autologous bone transplantation have been clinically used to treat knee joint cartilage defect and some curative effects have been acquired, but the precise therapeutic methods need further investigation.

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