中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (53): 9937-9940.doi: 10.3969/j.issn.1673-8225.2010.53.014

• 细胞与组织移植 cell and tissue transplantation • 上一篇    下一篇

受精第3天胚胎的融合程度与植入潜能

张  博，杨  菁，尹太郎，闫文杰，Rumana Jafarey   

  1. 武汉大学人民医院生殖医学中心，湖北省武汉市，430060
  • 出版日期:2010-12-31 发布日期:2010-12-31
  • 通讯作者: 杨菁，博士，教授，主任医师，博士生导师，主要从事生殖内分泌研究，武汉大学人民医院生殖医学中心，湖北省武汉市 430060 dryangqing@hotmail.com
  • 作者简介:张博☆，女，1985年生，湖北省襄樊市人，汉族，武汉大学在读博士，主要从事生殖内分泌研究。 dramanda1222@yahoo.cn

Correlation between early compaction and implantation potential on day 3 of fertilization

Zhang Bo, Yang Jing, Yin Tai-lang, Yan Wen-jie, Rumana Jafarey   

  1. Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan  430060, Hubei Province, China
  • Online:2010-12-31 Published:2010-12-31
  • Contact: Yang Jing, Doctor, Professor, Chief physician, Doctoral supervisor, Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China dryangqing@hotmail.com
  • About author:Zhang Bo☆, Studying for doctorate, Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China dramanda1222@yahoo.cn

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被引次数

2

摘要：

背景：虽然辅助生殖技术发展迅速，但是胚胎植入率仍不理想，关于胚胎融合程度与植入潜能的关系尚无定论。
目的：探讨受精第3天胚胎早期融合与植入率的相关性。
方法：回顾性分析420例(共移植胚胎1 016个)患者在超促排卵、体外受精及胚胎移植后，植入成功胚胎早期融合情况与未植入成功胚胎早期融合情况的差别。
结果及结论：受精第3天移植早期融合胚胎共200个，其中植入成功48个；受精第3天移植未早期融合胚胎共816个，其中植入成功133个，两组比较差异显著(P < 0.05)。植入胚胎中有3个早期融合胚胎妊娠率达71.43%，有2个为31.91%，有1个为51.06%，0个为39.81%。可见，在目前的胚胎选择标准下，胚胎早期融合可以显著提高胚胎的植入率，但是其具体机制，还有待进一步研究。

关键词: 胚胎早期融合, 植入率, 妊娠率, 胚胎移植, 受精

Abstract:

BACKGROUND: In spite of the fast development of the affiliated reproductive technology, the implantation rate of embryos is not very good. The correlation between early compaction and the implantation potential remains unclear. 
OBJECTIVE: To determine the correlation of early compaction on day 3 and the implantation rate.
METHODS: A total of 420 cases (1 016 embryos), who underwent controlled ovarian hyperstimulation and in vitro fertilization and embryo transfer were selected, and compared the implantation rate of day 3 embryos exhibiting early compaction and embryos without compaction.
RESULTS AND CONCLUSIONS: There were 200 embryos exhibiting early compaction, including 48 implanted embryos. At the same time, there were 816 embryos without early compaction, including 133 embryos implanted. There were significantly differences between two groups (P < 0.05). The pregnancy rate of the cases who received three compacted embryos was 71.43%, for those who received two compacted embryos was 31.91%, and those who received three compacted embryos was 51.06%, those who received non-compacted embryos was 39.81%. Accordingly, early compaction can notably increase implantation rate based on presently selection criteria of embryos. However, the precise mechanism still needs to be investigated.

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