中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (26): 6899-6906.doi: 10.12307/2026.362

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

氮化硼纳米片增强树脂基陶瓷的性能

张敏迪1，马  腾2，苏骑龙1，刁凯璇1，任光辉1，3   

  1. 1滨州医学院口腔医学院，山东省烟台市   264003；2中国科学院上海硅酸盐研究所，上海市   200050；3滨州医学院附属烟台口腔医院咬合中心，山东省烟台市   264000
  • 接受日期:2025-08-28 出版日期:2026-09-18 发布日期:2026-03-16
  • 通讯作者: 任光辉，副教授，滨州医学院口腔医学院，山东省烟台市 264003；滨州医学院附属烟台口腔医院咬合中心，山东省烟台市 264000
  • 作者简介:张敏迪，女，2000年生，山东省菏泽市人，汉族，滨州医学院口腔医学院在读硕士，主要从事口腔修复材料研究。

Properties of boron nitride nanosheet-reinforced resin-matrix ceramics

Zhang Mindi1, Ma Teng2, Su Qilong1, Diao Kaixuan1, Ren Guanghui1, 3   

  1. 1School of Stomatology, Binzhou Medical University, Yantai 264003, Shandong Province, China; 2Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; 3Center for Occlusion, Yantai Stomatological Hospital of Binzhou Medical University, Yantai 264000, Shandong Province, China
  • Accepted:2025-08-28 Online:2026-09-18 Published:2026-03-16
  • Contact: Ren Guanghui, Associate professor, School of Stomatology, Binzhou Medical University, Yantai 264003, Shandong Province, China; Center for Occlusion, Yantai Stomatological Hospital of Binzhou Medical University, Yantai 264000, Shandong Province, China
  • About author:Zhang Mindi, MS candidate, School of Stomatology, Binzhou Medical University, Yantai 264003, Shandong Province, China

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摘要：

文题释义：
氮化硼纳米片：是一种类石墨烯的二维纳米材料，由硼(B)和氮(N)原子以六方晶格结构交替排列而成，因结构与石墨烯相似常被称为“白色石墨烯”。氮化硼纳米片具有优异的力学性能、高热导率和低摩擦系数，同时具备良好的化学稳定性和生物相容性，层状结构使材料在剪切作用下易于滑移，表现出优异的润滑性能。
树脂基陶瓷：是一种有机-无机杂化材料，由树脂基质和无机填料复合而成，结合了树脂的可加工性与陶瓷的高强度特性。树脂基陶瓷具有与天然牙釉质相近的机械性能(如弹性模量和硬度)，同时具备良好的生物相容性和美观性，广泛应用于牙科修复领域，如牙冠、嵌体和贴面等。

背景：氮化硼纳米片在增强牙科材料性能方面展现出显著优势，但目前关于氮化硼纳米片增强树脂基陶瓷材料的研究仍处于初步探索阶段。
目的：探讨氮化硼纳米片添加量对树脂基陶瓷性能的影响规律。
方法：以60%双酚A甲基丙烯酸缩水甘油酯和40%三乙二醇二甲基丙烯酸酯作为树脂基质，钡玻璃粉作为无机填料，将质量分数83%的树脂基质与质量分数17%的钡玻璃粉混合制备树脂基陶瓷，同时以质量分数0.3%，0.5%，0.7%和0.9%的氮化硼纳米片替代钡玻璃粉，分别制备0.3%，0.5%，0.7%和0.9%氮化硼纳米片/树脂基陶瓷。将树脂基陶瓷与0.3%，0.5%，0.7%和0.9%氮化硼纳米片/树脂基陶瓷的浸提液分别与小鼠成纤维细胞L929(或人脐静脉内皮细胞)共培养，CCK-8法检测两种细胞存活率，活/死染色检测L929细胞活性。检测树脂基陶瓷与0.3%，0.5%，0.7%和0.9%氮化硼纳米片/树脂基陶瓷的润湿性、力学性能与磨损性能。
结果与结论：①与树脂基陶瓷及0.3%，0.5%，0.7%和0.9%氮化硼纳米片/树脂基陶瓷浸提液共培养后，L929细胞和人脐静脉内皮细胞的存活率均超过85%，无明显的细胞毒性；活/死染色显示树脂基陶瓷及0.3%，0.5%，0.7%和0.9%氮化硼纳米片/树脂基陶瓷浸提液未影响L929细胞活性。②随着材料中氮化硼纳米片质量分数的增加，树脂基陶瓷的水接触角增大，弯曲强度与显微硬度呈先升高后降低的趋势，其中0.5%氮化硼纳米片/树脂基陶瓷的弯曲强度与显微硬度最高。进行60 000次循环后，随着材料中氮化硼纳米片质量分数的增加，树脂基陶瓷的磨损深度和磨损体积均呈逐渐增大趋势；进行120 000次循环后，随着材料中氮化硼纳米片质量分数的增加，树脂基陶瓷的磨损深度和磨损体呈现先降低后升高的趋势。结果表明，适量添加氮化硼纳米片能够显著改善树脂基陶瓷的综合性能。

https://orcid.org/0000-0002-4315-9973 (张敏迪)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 氮化硼纳米片, 树脂基陶瓷, 细胞毒性, 接触角, 力学性能, 磨损性能, 球磨法, 温等静压法

Abstract: BACKGROUND: Boron nitride nanosheets have demonstrated remarkable advantages in enhancing the properties of dental materials. However, the current research on boron nitride nanosheets-reinforced resin-matrix ceramic materials is still in the preliminary exploration stage.
OBJECTIVE: To investigate the effect of boron nitride nanosheet addition on the properties of resin-matrix ceramics.
METHODS: 60% bisphenol A glycidyl methacrylate and 40% triethylene glycol dimethacrylate were used as the resin matrix, and barium glass powder was used as the inorganic filler. Resin-matrix ceramics were prepared by mixing 83% (mass fraction) of the resin matrix with 17% (mass fraction) of the barium glass powder. Meanwhile, boron nitride nanosheets were added to replace the barium glass powder at mass fractions of 0.3%, 0.5%, 0.7%, and 0.9% to prepare 0.3%, 0.5%, 0.7%, and 0.9% (mass fractions) of boron nitride nanosheet/resin-matrix ceramics, respectively. Resin-matrix ceramics were co-cultured with extracts of 0.3%, 0.5%, 0.7%, and 0.9% boron nitride nanosheets/resin-matrix ceramics, respectively, and mouse fibroblast L929 cells (or human umbilical vein endothelial cells). The CCK-8 assay was used to assess cell viability, and L929 cell viability was assessed using live/dead staining. The wettability, mechanical properties, and wear resistance of the resin-matrix ceramics and extracts of 0.3%, 0.5%, 0.7%, and 0.9% boron nitride nanosheets/resin-matrix ceramics were evaluated.
RESULTS AND CONCLUSION: (1) After co-culture with the resin-matrix ceramics and extracts of 0.3%, 0.5%, 0.7%, and 0.9% boron nitride nanosheets/resin-matrix ceramics, the survival rates of both L929 and human umbilical vein endothelial cells exceeded 85%, with no significant cytotoxicity. Live/dead staining revealed that the resin-matrix ceramics and extracts of 0.3%, 0.5%, 0.7%, and 0.9% boron nitride nanosheets/resin-matrix ceramics did not affect L929 cell viability. (2) With increasing boron nitride nanosheet mass fraction, the water contact angle of the resin-matrix ceramic increased, while the flexural strength and microhardness first increased and then decreased. The 0.5% boron nitride nanosheet/resin-matrix ceramic exhibited the highest flexural strength and microhardness. After 60 000 cycles, the wear depth and wear volume of the resin-matrix ceramic gradually increased with increasing boron nitride nanosheet mass fraction. After 120 000 cycles, the wear depth and wear volume of the resin-matrix ceramic first decreased and then increased with increasing boron nitride nanosheet mass fraction. These results indicate that the appropriate addition of boron nitride nanosheets can significantly improve the overall properties of resin-matrix ceramics.


Key words: boron nitride nanosheet, resin-matrix ceramics, cytotoxicity, contact angle, mechanical property, wear property, ball milling method;, warm isostatic pressing method

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