中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (3): 795-804.doi: 10.12307/2025.928

• 植入物相关大数据分析 Implant related big data analysis • 上一篇    

全膝关节置换后疼痛：研究现状及趋势分析

章安琪1，化昊天1，蔡恬媛1，王子成1，孟  卓1，占效谦1，陈国茜2   

  1. 1浙江中医药大学，浙江省杭州市  310000；2浙江省中医院骨伤科，浙江省杭州市  310000
  • 收稿日期:2024-09-25 接受日期:2024-11-19 出版日期:2026-01-28 发布日期:2025-07-10
  • 通讯作者: 陈国茜，博士，主治医师，浙江省中医院骨伤科，浙江省杭州市 310000
  • 作者简介:章安琪，女，2004年生，浙江省台州市人，汉族，浙江中医药大学本科生。
  • 基金资助:
    浙江省中医药科技计划项目(2023ZL369)，项目负责人：陈国茜

Pain after total knee arthroplasty: current status and trend analysis

Zhang Anqi1, Hua Haotian1, Cai Tianyuan1, Wang Zicheng1, Meng Zhuo1, Zhan Xiaoqian1, Chen Guoqian2   

  1. 1Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China; 2Department of Orthopedics, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310000, Zhejiang Province, China
  • Received:2024-09-25 Accepted:2024-11-19 Online:2026-01-28 Published:2025-07-10
  • Contact: Chen Guoqian, MD, Attending physician, Department of Orthopedics, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310000, Zhejiang Province, China
  • About author:Zhang Anqi, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China
  • Supported by:
    Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project, No. 2023ZL369 (to CGQ)

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摘要：

文题释义：

全膝关节置换术(Total Knee Arthroplasty，TKA)：是一种广泛认可用于治疗严重膝关节疼痛和功能障碍的手术方式。采用外科手术切除膝关节受损表面，以人工假体替换，以恢复关节功能、缓解疼痛。全膝关节置换术通常适用于骨关节炎、骨坏死、关节畸形等所致膝关节病变。
术后疼痛：是指患者在手术结束后所经历的疼痛感，这种疼痛通常是由于手术过程中对身体组织造成的损伤和炎症反应引起的。

摘要
背景：接受全膝关节置换患者人数在全球范围内逐年增加，全膝关节置换后的疼痛管理是一个重要的方面，因为有效的疼痛控制可以促进患者早期活动，减少并发症，提高患者满意度，并加快康复进程。
目的：构建全膝关节置换后疼痛的可视化图谱，了解该领域的国际研究现状及趋势，为日后研究提供参考依据。
方法：在中国知网、万方数据库、Web of Science核心数据库检索从2000年1月至2023年12月有关全膝关节置换患者术后疼痛的研究文献。使用CiteSpace(6.2.3版本)可视化软件分析文献年发文量、作者、机构、国家、关键词、参考文献等内容。并使用R语言(4.4.1版本)软件建立数据库进行折线图、条形图的绘制。
结果与结论：①共纳入3 796篇文献，包括中文文献3 509篇、英文文献287篇。②在英文数据库中，美国为发文量最高的国家，哈佛大学则是发文量最多的机构；中文数据库中，广州中医药大学发文量居首。③通过关键词聚类分析，中文文献近5年突现关键词包括“生活质量”“恐动症”和“针刺”；英文文献的突现关键词则为“满意度”和“心理因素”。共现图和聚类图分析显示，机构-作者-文献呈现内部集体联系紧密，外部合作松散。④由于可视化分析方法排除了部分影响力较低的文献，研究结果可能存在一定的偏倚。⑤研究热点方面，国内外存在差异：国内研究侧重于镇痛手段的有效性论证和方式探索，而国外研究则更关注疼痛机制的细分及镇痛药物的改良与替代。未来研究的发展趋势预计将集中在手术后疼痛的中医药治疗、多模式镇痛联合应用以及疼痛分型机制的探究和预防。


中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

关键词: 全膝关节置换术, TKA, 术后疼痛, 镇痛, CiteSpace, 数据可视化"研究现状, 趋势

Abstract: BACKGROUND: The number of patients receiving total knee arthroplasty has been increasing globally each year. Pain management is a crucial aspect following total knee arthroplasty, as effective pain control can facilitate early mobilization, reduce complications, enhance patient satisfaction, and accelerate the rehabilitation process. 
OBJECTIVE: To construct a visual map of post-total knee arthroplasty pain, understand the international research status and trends in this field, and provide a reference for future studies.
METHODS: Relevant research articles on post-total knee arthroplasty pain were retrieved from the CNKI, WanFang Data, and Web of Science core databases, covering the period from January 2000 to December 2023. The CiteSpace software (version 6.2.3) was used to analyze the annual publication output, authors, institutions, countries, keywords, and references. Utilizing R programming language (version 4.4.1), a database was established to create line charts and bar graphs. 
RESULTS AND CONCLUSION: (1) Our analysis included 3 796 publications, predominantly in Chinese (3 509 articles) with the remainder in English (287 articles). (2) The United States was the most productive country in English literature, with Harvard University leading institutional output. Guangzhou University of Chinese Medicine was the top publishing institution in Chinese literature. (3) Keyword clustering identified “quality of life,” “phobia,” and “acupuncture” as emerging focal points in Chinese literature, while “satisfaction” and “psychological factors” were prominent in English literature over the past five years. Co-occurrence and clustering analysis revealed dense internal connections among institutions, authors, and publications, but sparse external collaborations. (4) The study’s bias on visualization analysis may have introduced bias by excluding less influential papers. (5) Regarding research hotspots, domestic research emphasized the efficacy and exploration of analgesic methods, in contrast to international research that focused on pain mechanism subtyping and analgesic drug innovation. Future research is expected to trend towards traditional Chinese medicine for postoperative pain, multimodal analgesia, and the investigation and prevention of pain typing mechanisms.

Key words: total knee arthroplasty, TKA, postsurgical pain, analgesia, CiteSpace, data visualization, research status, tendency

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