中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (26): 5652-5661.doi: 10.12307/2025.725

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    下一篇

肠道菌群调节骨代谢：来自Web of Science核心合集数据库文献的可视化分析

曾  浩1，邹顺一1，黎征鹏1，柴  源1，2，黄有荣1，2，章晓云1，2   

  1. 1广西中医药大学，广西壮族自治区南宁市  530001；2广西中医药大学附属瑞康医院骨科，广西壮族自治区南宁市  530011

  • 收稿日期:2024-09-09 接受日期:2024-10-18 出版日期:2025-09-18 发布日期:2025-02-27
  • 通讯作者: 章晓云，博士，副主任医师，硕士生导师，广西中医药大学附属瑞康医院骨科，广西壮族自治区南宁市 530001；广西中医药大学，广西壮族自治区南宁市 530001。
  • 作者简介:曾浩，男，1999年生，河南省周口市人，汉族，广西中医药大学在读硕士，主要从事脊柱、骨关节创伤性疾病的防治研究。
  • 基金资助:
    国家自然科学基金资助项目(82360937)，项目负责人：章晓云；广西自然科学基金面上项目(2023GXNSFAA026075)，项目负责人：章晓云；广西中医药适宜技术开发与推广项目(GZSY22-36)，项目负责人：章晓云；黄有荣桂派中医大师培养项目(项目文号：桂中医药科教发[2022]6号)，项目负责人：黄有荣；广西研究生教育创新计划项目(YCSY2023038)，项目负责人：曾浩

Intestinal flora regulates bone metabolism: a visual analysis of literature from the Web of Science Core Collection

Zeng Hao1, Zou Shunyi1, Li Zhengpeng1, Chai Yuan1, 2, Huang Yourong1, 2, Zhang Xiaoyun1, 2   

  1. 1Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China; 2Department of Orthopedics, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • Received:2024-09-09 Accepted:2024-10-18 Online:2025-09-18 Published:2025-02-27
  • Contact: Zhang Xiaoyun, MD, Associate chief physician, Master’s supervisor, Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China; Department of Orthopedics, Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • About author:Zeng Hao, Master candidate, Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    National Natural Science Foundation of China, No. 82360937 (to ZXY); Natural Science Foundation of Guangxi Zhuang Autonomous Region (General Program), No. 2023GXNSFAA026075 (to ZXY); Guangxi Traditional Chinese Medicine Appropriate Technology Development and Promotion Project, No. GZSY22-36 (to ZXY); Huang Yourong GUI School of Traditional Chinese Medicine Master Training Project, No. [2022]6 (to HYR); Innovation Project of Guangxi Graduate Education, No. YCSY2023038 (to ZH)

PDF

190

摘要：


文题释义：
文献计量学：作为一种统计学方法，可以帮助研究者了解某一领域的研究现状、热点和发展趋势，为进一步的研究和决策提供一定的数据支持。 
可视化分析：将复杂的数据信息转换成易于理解的图像，以便研究者能直观地了解某一研究领域的模式、趋势、关联性等信息。

背景：近年来，多项研究证实了肠道菌群可通过多种途径调节骨代谢，成为骨科和微生物学领域的研究热点，但目前仍无研究对该领域进行文献计量学和可视化分析。
目的：分析肠道菌群调节骨代谢领域的研究现状、热点及发展趋势，为后续研究提供一定的数据支持及参考依据。
方法：以Web of Science核心合集数据库为检索平台，检索2004-2024年肠道菌群调节骨代谢领域的相关文献，应用Citespace软件对纳入文献进行可视化分析并生成可视化图谱。
结果与结论：①最终纳入1 035篇文献，近20年间肠道菌群调节骨代谢领域的发文量呈现显著增长趋势，美国和中国在该领域研究及出版活动中占据主导地位，哈佛大学和加州大学系统是发文量和研究中心性均较高的研究机构，埃默里大学的Pacifici R教授是发文量最大的作者；②炎症性肠病、链式脂肪酸、骨髓为核心关键词，绝经后骨质疏松症、类风湿性关节炎、氧化应激、线粒体功能障碍是最新研究前沿；③在文献被引频次排名前10的文献中，4篇文献探讨了短链脂肪酸影响骨代谢的机制；3篇文献探讨了肠道菌群分别在绝经后骨质疏松症、糖皮质激素性骨质疏松症和老年性骨质疏松症中的发病机制及治疗潜力；1篇文献探讨了肠道炎症与肠道菌群、甲状旁腺激素和骨代谢的关联性；1篇文献探讨了鼠李糖乳杆菌、T细胞对肠道菌群和骨代谢的影响；④《NUTRIENTS》期刊收录文献最多，《ENDOCRINOLOGY & METABOLISM》期刊收录的文献被引用次数最高；⑤综合文献共被引分析和关键词，探索肠道菌群在绝经后骨质疏松症和类风湿性关节炎疾病中的具体发病机制及治疗策略，揭示调控肠道菌群抑制氧化应激和改善线粒体功能障碍影响骨代谢的分子机制，将机制研究转化到临床应用，共同构成未来该领域的研究方向和趋势。
https://orcid.org/0000-0002-9084-0294(曾浩)；https://orcid.org/0000-0002-2572-0229(章晓云)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 文献计量学, 可视化分析, 肠道菌群, 骨代谢, 共现分析, 研究热点, CiteSpace, 大数据分析

Abstract: BACKGROUND: In recent years, a number of studies have confirmed that gut microbiome regulates bone metabolism through multiple pathways, and this field has become a research hotspot in orthopedics and microbiology. However, there is still no literature metrology and visual analysis on this field.
OBJECTIVE: To explore the research status, hot spots and development trends in the field of gut microbiome regulation of bone metabolism, and to provide certain data support and reference for subsequent studies.
METHODS: The Web of Science core collection database was used as the retrieval platform to retrieve the related literature in the field of intestinal flora regulating bone metabolism from 2004 to 2024. Citespace software was used to visually analyze the included literature and generate a visual atlas.
RESULTS AND CONCLUSION: (1)  A total of 1,035 papers were included in this study. In the past 20 years, the number of publications in the field of gut microbiome regulation of bone metabolism has shown a significant growth trend, with the United States and China dominating research and publication activities in this field. Harvard University and the University of California system are the research institutions with the highest number of published papers and research centrality in this area, and Professor Pacifici R of Emory University is the most prolific author. (2) Inflammatory bowel disease, chain fatty acids, bone marrow are the core keywords in this field. Postmenopausal osteoporosis, rheumatoid arthritis, oxidative stress, mitochondrial dysfunction are the latest research frontiers in this field. (3) Among the top 10 cited papers, 4 discussed the mechanism of short-chain fatty acids affecting bone metabolism; 3 investigated the pathogenesis and therapeutic potential of intestinal flora in postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, and senile osteoporosis; 1 discussed the relationship between intestinal inflammation, intestinal flora, parathyroid hormone, and bone metabolism; and 1 examined the effects of Lactobacillus rhamnosus and T cells on the gut microbiome and bone metabolism. (4) NUTRIENTS has the most papers, while ENDOCRINOLOGY & METABOLISM has the most citations. (5) Based on literature co-citation analysis and keywords, further exploration is needed on the specific pathogenesis and treatment strategies of gut microbiome in postmenopausal osteoporosis and rheumatoid arthritis, revealing the molecular mechanism of regulating gut microbiota to inhibit oxidative stress and improve mitochondrial dysfunction affecting bone metabolism, and translating mechanism research into clinical application, which all constitute the future research directions and trends in this field.

Key words: bibliometrics, visual analysis, gut microbiota, bone metabolism, co-occurrence analysis, research hotspot, CiteSpace, big data analysis

中图分类号: