中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (20): 4389-4400.doi: 10.12307/2025.701

• 组织构建相关数据分析 Date analysis of organization construction • 上一篇    

Theta爆发式经颅磁刺激的文献计量学和可视化分析

高文艳1，郑兆燕2，潘  尚2，王佩佩2，吉春辉3，吕少萍2   

  1. 1山东中医药大学康复医学院，山东省济南市  250355；2康复大学青岛中心医院康复医学科，山东省青岛市  266042；3天津大学机械工程学院，天津市  300350
  • 收稿日期:2024-08-05 接受日期:2024-09-23 出版日期:2025-07-18 发布日期:2024-12-25
  • 通讯作者: 吕少萍，博士，主任医师，教授，康复大学青岛中心医院康复医学科，山东省青岛市 266042
  • 作者简介:高文艳，女，1999年生，山东省滨州市人，汉族，山东中医药大学在读硕士，主要从事重复经颅磁刺激和神经康复相关研究。
  • 基金资助:
    国家自然科学基金项目(32271432)，项目负责人：吉春辉；青岛市医药科研指导计划项目(2023-WJZD206，2022-WJZD052)，项目负责人：吕少萍；青岛市医药科研指导计划项目(2023-WJZD224，2022-WJZD053)，项目负责人：王佩佩

Bibliometric and visual analysis of Theta burst transcranial magnetic stimulation

Gao Wenyan1, Zheng Zhaoyan2, Pan Shang2, Wang Peipei2, Ji Chunhui3, Lyu Shaoping2   

  1. 1College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China; 2Department of Rehabilitation Medicine, Qingdao Central Hospital of Rehabilitation University, Qingdao 266042, Shandong Province, China; 3College of Mechanical Engineering, Tianjin University, Tianjin 300350, China 
  • Received:2024-08-05 Accepted:2024-09-23 Online:2025-07-18 Published:2024-12-25
  • Contact: Lyu Shaoping, PhD, Chief physician, Professor, Department of Rehabilitation Medicine, Qingdao Central Hospital of Rehabilitation University, Qingdao 266042, Shandong Province, China
  • About author:Gao Wenyan, Master’s candidate, College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 32271432 (to JCH); Qingdao Medical Research Guidance Projects, Nos. 2023-WJZD206 (to LSP), 2022-WJZD052 (to LSP), 2023-WJZD224 (to WPP), and 2022-WJZD053 (to WPP)

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摘要：


文题释义：
Theta爆发式经颅磁刺激：是经颅磁刺激的一种特殊模式，通过模拟海马区的神经放电节律，可在短时间内快速调节大脑产生长时程增强/抑制效应，从而影响皮质兴奋性和神经生理活动。
CiteSpace：是一款基于文献计量学的可视化分析软件，可通过绘制网络共现、聚类、共被引、时间演化及突现的知识图谱，直观展示研究领域的发展动态、热点和前沿。

背景：相比于常规重复经颅磁刺激，Theta爆发式经颅磁刺激因具有刺激时间短、效率高、安全性好和效果持久等优势，正受到各领域学者的广泛关注，研究热度持续上升。
目的：通过对近20年国际Theta爆发式经颅磁刺激研究进行文献计量学的可视化分析，梳理Theta爆发式经颅磁刺激研究的发展脉络，总结研究现状，揭示研究热点和发展趋势，为后续研究提供借鉴和参考。
方法：检索Web of Science核心集数据库中2005年1月至2024年6月有关Theta爆发式经颅磁刺激的相关文献，应用CiteSpace软件进行年度发文量分析，国家、机构和作者合作共现分析，参考文献、期刊和作者共被引分析，关键词共现、聚类、时间演化和突现分析等，并绘制可视化知识图谱。
结果与结论：①共纳入1 914篇文献，近20年Theta爆发式经颅磁刺激研究量呈总体上升趋势，预计未来将继续保持研究热度。②发文量前3位的国家为美国、中国和意大利，机构为加拿大多伦多大学、英国伦敦大学和美国哈佛大学医学院；美国哈佛大学医学院的
Pascual-leone，Alvaro研究成果最多，中国长庚大学的HUANG YZ被引频次最高；《NEURON》为影响力最大的期刊。③高频关键词、高被引文献和聚类主题结果显示，近20年Theta爆发式经颅磁刺激研究热点主要集中于：Theta爆发式经颅磁刺激对突触可塑性和神经生理活动的作用机制，Theta爆发式经颅磁刺激刺激不同脑区靶点的作用效果(包括运动皮质、背外侧前额叶皮质、前扣带皮质和小脑等)，以及Theta爆发式经颅磁刺激对神经和精神疾病的疗效探讨(包括抑郁症、帕金森病运动障碍、脑卒中后运动障碍和认知障碍，以及阿尔茨海默病记忆障碍等)。此外，综述和临床试验类文献被引频次最高，未来可重点关注。④关键词突现、文献突现和关键词时间演化分析显示，“重度抑郁症、应用指南、评定量表、疗效、障碍、难治性抑郁症、Meta分析”等不仅是当前的研究热点，也是未来的研究趋势。⑤未来，Theta爆发式经颅磁刺激研究应加强核心作者和机构的区域性合作，发掘其在临床难治性疾病中的应用，通过结合前沿技术和优化刺激参数，实现Theta爆发式经颅磁刺激应用的精准化、个性化和最优化，解决更多临床难题。
https://orcid.org/0009-0005-9479-1345 (高文艳)；https://orcid.org/0009-0000-9169-7779 (吕少萍)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: Theta爆发式经颅磁刺激, 文献计量学, CiteSpace, 可视化分析, 可塑性, 长时程增强, 长时程抑制

Abstract: BACKGROUND: Compared with conventional repetitive transcranial magnetic stimulation, Theta burst transcranial magnetic stimulation (TBS) has attracted extensive attention from scholars in various fields due to its advantages of short stimulation time, high efficiency, good safety and long-lasting effect, and the research popularity continues to rise. 
OBJECTIVE: Through the visual bibliometrics analysis of international TBS research in the past 20 years, to sort out the development context of TBS research, summarize the research status, reveal research hotspots and development trends, and provide reference for subsequent research.
METHODS: Relevant studies on TBS from January 2005 to June 2024 were searched in the Web of Science Core Collection database. CiteSpace software was used to perform annual publication volume analysis, co-occurrence analysis of countries, institutions and authors, and co-citation analysis of references, journals and authors, keywords co-occurrence, clustering, time evolution and emergence analysis, and so on, and draw the visual knowledge map. 
RESULTS AND CONCLUSION: (1) After screening, a total of 1914 papers were included in the study, and the amount of TBS research has shown an overall increasing trend over the past 20 years, and it is expected to continue to be a hot topic of research in the future. (2) The top three countries in terms of number of publications are the United States, China and Italy, and the top three institutions are the University of Toronto, the University of London and Harvard Medical School. Pascual-leone Alvaro from Harvard Medical School has the most research achievements, and HUANG YZ from Chang Gung University has the most citations. NEURON is the most influential core journal. (3) Analyses of high-frequency keywords, highly cited references and clustering topics showed that the research hotspots of TBS in the past 20 years mainly focus on the mechanism of TBS on synaptic plasticity and neurophysiological activity, the effect of TBS on stimulating targets in different brain regions (including the motor cortex, dorsolateral prefrontal cortex, anterior cingulate cortex and cerebellum, etc.), and the therapeutic effect of TBS on neurological and psychiatric diseases (including depression, Parkinson’s disease movement disorder, post-stroke movement disorder and cognitive impairment, and Alzheimer’s disease memory disorders). (4)Keyword burst, literature emergence and keyword temporal evolution analyses showed that “major depression, application guidelines, rating scale, efficacy, disorder, refractory depression, meta-analysis, etc.” are not only current research hotspots, but also future research trends. (5) In the future, TBS research should strengthen the regional cooperation of core authors and institutions, explore the clinical application in the treatment of refractory diseases, and realize the precision, personalization and optimization of TBS application by combining cutting-edge technologies and optimizing stimulus parameters, so as to solve more clinical problems.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Theta burst transcranial magnetic stimulation, bibliometrics, CiteSpace, visual analysis, plasticity, long-term potentiation, long-term depression

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