中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (11): 1781-1787.doi: 10.3969/j.issn.2095-4344.1115

• 组织构建综述 tissue construction review • 上一篇    下一篇

有氧运动通过鸢尾素改善慢性心力衰竭的机制

毋江波1,2,谢安青3,张  勇2   

  1. (1北京体育大学运动人体科学学院,北京市  100084;2天津体育学院运动生理与运动医学重点实验室,天津市  301617;3天津体育学院研究生院,天津市  301617)
  • 收稿日期:2018-11-22 出版日期:2019-04-18 发布日期:2021-04-28
  • 通讯作者: 张勇,博士,教授,博士生导师,天津体育学院运动生理与运动医学重点实验室,天津市301617
  • 作者简介:毋江波,男,1987年生,河南省焦作市人,汉族,北京体育大学在读博士,助理研究员,主要从事细胞与运动分子生理学的研究。
  • 基金资助:

    国家自然科学基金(81370454),项目负责人:张勇;天津市应用基础与前沿技术研究计划重点项目(14JCZDJC36600),项目负责人:张勇;天津市自然科学基金青年项目(18JCQNJC12400),项目负责人:毋江波

Mechanism of aerobic exercise improving chronic heart failure by irisin

Wu Jiangbo1,2,Xie Anqing3,Zhang Yong2   

  1.  (1Sport Science College, Beijing Sport University, Beijing 100084, China; 2Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 301617, China; 3Graduate School, Tianjin University of Sport, Tianjin 301617, China)
  • Received:2018-11-22 Online:2019-04-18 Published:2021-04-28
  • Contact: Zhang Yong, MD, Professor, Doctoral supervisor, Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 301617, China
  • About author:Wu Jiangbo, Doctoral candidate, Assistant researcher, Sport Science College, Beijing Sport University, Beijing 100084, China; Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Tianjin University of Sport, Tianjin 301617, China
  • Supported by:

    the National Natural Science Foundation of China, No.81370454 (to ZY); the Key Project of Tianjin Application Foundation and Frontier Technology Research Program, No. 14JCZDJC36600 (to ZY); the Youth Project of Tianjin Natural Science Foundation, No. 18JCQNJC12400 (to WJB)

摘要:

文章快速阅读:

文题释义:
心力衰竭:是由于心脏工作能力减弱,心排血量降低,静脉系统淤血以及动脉系统灌注不足引起的一组心脏循环症候群。它与心肌线粒体稳态异常以及心肌能量代谢紊乱等密切相关。
鸢尾素:是一种新发现的肌肉因子和脂肪因子,可由运动诱导产生。鸢尾素可在一定程度上改善氧化应激造成的心肌细胞线粒体稳态异常,包括提高能量代谢、抑制活性氧产生和改善线粒体网络结构。鸢尾素对心脏功能起保护作用,可能成为慢性心力衰竭及其相关疾病的潜在治疗靶点。
摘要
背景:
慢性心力衰竭与心肌线粒体稳态异常以及心肌能量代谢紊乱等密切相关。解偶联蛋白2是位于线粒体内膜上的质子泵,与心肌的氧化应激、能量代谢和细胞凋亡关系密切,在慢性心力衰竭病理生理过程中起着极其重要作用。
目的:总结鸢尾素对慢性心力衰竭的影响,讨论有氧运动通过鸢尾素改善慢性心力衰竭的机制。
方法:应用计算机检索PubMed和CNKI等数据库从2001年至2018年收录的与鸢尾素和慢性心力衰竭相关的文献。英文检索词为:“aerobic exercise”,“Irisin”,“chronic heart failure”,中文检索词为:“有氧运动”,“鸢尾素”,“慢性心力衰竭”。排除无关和重复文献,最后纳入53篇文章进行分析总结,包括8篇中文和45篇英文文献。
结果与结论:鸢尾素可抑制活性氧生成,可以模拟有氧运动带来的良好效益,在有氧运动改善慢性心力衰竭中起着重要的作用,因此鸢尾素可作为运动治疗心力衰竭的潜在靶点。长期的有氧运动可能通过鸢尾素/活性氧/解耦联蛋白2途径改善心力衰竭过程。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0001-6536-8533(毋江波)

关键词: 有氧运动, 慢性心力衰竭, 靶向治疗, 鸢尾素, Irisin, 解偶联蛋白2, 活性氧, 锰超氧化物歧化酶, 线粒体稳态, 国家自然科学基金

Abstract:

BACKGROUND: Chronic heart failure is closely related to the homeostasis of myocardial mitochondria and disorders of myocardial energy metabolism. As a proton pump on the membrane of mitochondria, uncoupling protein 2 is closely related to myocardial oxidative stress, energy metabolism and cardiomyocyte apoptosis. It plays an extremely important part in the pathophysiological process of myocardium.
OBJECTIVE: To review the effects of irisin on chronic heart failure and explore the mechanism of aerobic exercise improving chronic heart failure by irisin.
METHODS: A computer-based retrieval of PubMed and CNKI databases was performed to search relevant articles concerning irisin and chronic heart failure published from 2001 to 2018, using the keywords “aerobic exercise, irisin, chronic heart failure” in English and Chinese, respectively. After removal of repetitive and irrelevant articles, 53 eligible articles were finally reviewed, including 45 English and 8 Chinese articles.
RESULTS AND CONCLUSION: Irisin may inhibit the production of reactive oxygen species and simulate the good benefits of aerobic exercise. Irisin plays an important role in aerobic exercise improving chronic heart failure and serves as a potential target for exercise therapy for heart failure. Long-term aerobic exercise may improve heart failure through the irisin/reactive oxygen species/uncoupling protein 2 pathway.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Heart Failure, Oxidative Stress, Mitochondria, Heart, Tissue Engineering

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