中国组织工程研究

• 生物材料综述 biomaterial review • 上一篇    下一篇

3D挤压成型生物打印含细胞水凝胶的理化性能

顾亚伟,李 牧,范子文,王 龙,李泽遥,陈 昶   

  1. 同济大学附属上海市肺科医院胸外科,上海市 200433
  • 收稿日期:2017-12-03 出版日期:2018-08-08 发布日期:2018-08-08
  • 通讯作者: 陈昶,教授,同济大学附属上海市肺科医院胸外科,上海市 200433
  • 作者简介:顾亚伟,男,1992年生,江苏省丹阳市人,汉族,硕士,主要从事气管修复、组织工程研究。
  • 基金资助:

     上海市科学技术委员会科研计划项目(15JC1490900)

Physical and chemical properties of 3D extrusive bioprinting cell-encapsulated hydrogel

Gu Ya-wei, Li Mu, Fan Zi-wen, Wang Long, Li Ze-yao, Chen Chang   

  1. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
  • Received:2017-12-03 Online:2018-08-08 Published:2018-08-08
  • Contact: Chen Chang, Professor, Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
  • About author:Gu Ya-wei, Master, Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
  • Supported by:

    the Scientific Plan Program of Shanghai Science and Technology Committee, No. 15JC1490900

摘要:

文章快速阅读:

 

文题释义:
3D生物打印:其核心观念为直接打印负载细胞的生物材料构成支架,这一新概念的优点在于:细胞的浓度和空间分布及其他物理因素可控制;有助于细胞的迁移,可实现较大较厚组织的构建;在打印的材料中可以添加其他生物、化学因子。
 
 
背景:目前3D生物打印技术可用于打印无细胞材料和含细胞材料,在解决器官、补片短缺的问题上开辟了新方法。
目的:综述近年国内外有关3D挤压成型生物打印的研究,总结该打印方法的原理、所用水凝胶种类、水凝胶的生物理化性能等最新进展。
方法:以“3D bioprinting/three-dimensional bioprinting;extrusion/extrusive;cell-laden/cells/cellular;hydrogel”为检索词,应用计算机搜索PubMed数据库2006至2016年的相关文献。

结果与结论:3D挤压成型生物打印技术生产原理简单,过程可控,产能较少,不仅可通过快速成型个性化地制造器官支架,而且可使细胞可控地分布于支架中,更加精确地构建符合生理空间的含细胞组织。然而,细胞在水凝胶内的生物学行为、水凝胶与细胞之间的相互作用、打印精度微纳米级别的提升目前仍在探索和研究阶段。随着这些问题的深入探讨和逐步解决,3D生物打印有望在未来成为组织工程学中的新的构建方法。

ORCID: 0000-0002-4908-1433(顾亚伟)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 生物材料, 水凝胶, 3D生物打印, 挤压成型, 组织工程

Abstract:

BACKGROUND: 3D bioprinting technology can be used to print non-cell and cell-laden materials, which provides a new pathway to solve the lack of transplanted organs or bio-patches.

OBJECTIVE: To conclude the printing mechanisms, kinds, biological and mechanical characteristics of hydrogels based on the development and advance in 3D extrusive bioprinting hydrogel.
METHODS: A computer-based search of PubMed database was performed to retrieve relevant articles published between 2006 and 2016, with the keywords of “3D bioprinting/three-dimensional bioprinting; extrusion/extrusive; cell-laden/cells/cellular; hydrogel”.

RESULTS AND CONCLUSION: 3D bioprinting is characterized as simple principle, controlled process, and less energy production, which can manufacture personalized organs or scaffolds by rapid prototyping technology, and precisely construct tissues with controllably distributed cells to mimics the physiological circumstance. However,

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

 

the following aspects are still at an initial stage, including the biological behaviors of cells in hydrogel, the interactions between cells and hydrogels and the elevation of micro-nano precision of printing. With solutions to these problems, 3D bioprinting may become another novel construction method in the tissue engineering.

Key words: Hydrogels, Ink, Tissue Engineering

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