中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (46): 6986-6992.doi: 10.3969/j.issn.2095-4344.2016.46.020

• 组织构建综述 tissue construction review • 上一篇    

运动性心肌顿抑:事实还是谬论?

李顺昌1,2   

  1. 1西昌学院体育学院,四川省西昌市  615022;2北京体育大学运动人体科学学院,北京市  100084
  • 收稿日期:2016-08-16 出版日期:2016-11-11 发布日期:2016-11-11
  • 通讯作者: Li Shun-chang, Studying for doctorate, Lecturer, School of Sports Science of Xichang University, Xichang 615022, Sichuan Province, China; Sport Science College of Beijing Sport University, Beijing 100084, China
  • 作者简介:李顺昌,男,1983年生,河南省林州市人,在读博士,讲师,主要从事运动生理学的研究。
  • 基金资助:

    国家体育总局科研项目(10B038);西昌学院自然科学项目(XA1205);国家留学基金资助(201405620017)

Exercise-induced myocardial stunning: fantasy or reality?

Li Shun-chang1, 2   

  1. 1School of Sports Science of Xichang University, Xichang 615022, Sichuan Province, China; 2Sport Science College of Beijing Sport University, Beijing 100084, China
  • Received:2016-08-16 Online:2016-11-11 Published:2016-11-11
  • Supported by:

    the Scientific Research Project of General Administration of Sport of China, No. 10B038; the Natural Science Foundation of Xichang University, No. XA1205; the Grant from China Scholarship Council, No. 201405620017

摘要:

文章快速阅读:

文题释义:
心肌顿抑:又称缺血后心肌功能障碍,是指心肌短暂缺血尚未造成心肌坏死,但再灌注恢复正常的血流后其机械功能障碍却需数小时、数天或数周才能完全恢复的现象。
热休克蛋白:又称热激蛋白,简称为HSP。是一类功能性相关蛋白质,当细胞受到升高温度或其他压力时它们的表达就会增长。这种表达的增长是受到转录调控的。热休克蛋白戏剧性地上调控是热休克反应的关键部分并且主要由热休克因子引导。在几乎所有生物中都发现了热休克蛋白,从细菌到人类。

摘要
背景:
系统性研究指出,长时间大强度运动诱发的可逆性心肌功能障碍与临床心肌顿抑所出现的心室功能障碍过程有明显的相似性。
目的:试图将运动性心肌顿抑国内外研究进行梳理,为大强度运动与运动风险关系研究提供理论依据和实践指导。
方法:应用计算机在PubMed和CNKI数据库检索1964年2月至2016年2月期间与运动性心肌顿抑相关的国内外文献。检索关键词“exercise,myocardial stunning”OR“exercise-induced myocardial stunning”和“运动,心肌顿抑”或“运动性心肌顿抑”。纳入符合标准的文献50篇进行分析。
结果与结论:心肌顿抑是一种与心肌缺血再灌注相关的心脏功能障碍的现象。关于心肌顿抑和运动训练关系的研究目前主要集中在运动训练对心肌顿抑的保护作用上。运动诱发心血管疾病患者出现心肌顿抑现象已被证实,且已有研究发现力竭性跑台运动诱发大鼠心肌顿抑现象。由于运动训练引起的心脏结构和功能变化也被国内外学者广泛研究,因而,运动训练诱发正常人的运动性心肌顿抑现象应该存在。分析结果,运动性心肌顿抑现象确实存在,是研究运动风险安全上限的重要概念,具有深远的现实意义。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

ORCID: 0000-0002-6738-506X(李顺昌)

关键词: 组织构建, 组织工程, 心肌顿抑, 抗氧化剂, 热休克蛋白, 运动性心肌顿抑

Abstract:

BACKGROUND: A series of studies have pointed out that the reversible myocardial dysfunction caused by long-term and high-intensive exercising is similar to the ventricular dysfunction following myocardial stunning. 
OBJECTIVE: To review the research of exercise-induced myocardial stunning at home and abroad, and to provide theoretical basis and practical guidance for study on the relationship of high-intensive exercising with exercise risks.
METHODS: The articles about exercise-induced myocardial stunning published from February 1964 to February 2016, were searched from PubMed and CNKI databases with the keywords of “exercise, myocardial stunning” OR “exercise-induced myocardial stunning” in English and Chinese, respectively. Finally 50 eligible literatures were enrolled for analysis.
RESULTS AND CONCLUSION: Myocardial stunning, a symptom of heart dysfunction, is closely linked with ischemia/reperfusion. The present research on the relationship between exercise and myocardial stunning mainly focuses on the protection of exercise against myocardial stunning. It has been confirmed that the myocardial stunning can be induced by exercise in patients with cardiovascular diseases, and myocardial stunning occurs in rats undergoing exhaustive treadmill running. Changes of heart structure and function caused by exercising have been extensively explored, so exercise-induced myocardial stunning should exist in healthy people. To conclude, exercise-induced myocardial stunning does exist, and is an important concept to assess the risk of strenuous exercise.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Myocardial Stunning, Antioxidants, HSP70 Heat-Shock Proteins, Sports Medicine

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