中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (35): 9345-9354.doi: 10.12307/2026.266

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

帕金森病动物模型：研究现状与趋势分析

李会萍，贾欢欢，赵维波   

  1. 广东省生物技术研究院(广东省实验动物监测中心)，广东省广州市   510663
  • 收稿日期:2025-09-28 修回日期:2025-12-08 出版日期:2026-12-18 发布日期:2026-04-30
  • 通讯作者: 赵维波，硕士，研究员，广东省生物技术研究院(广东省实验动物监测中心)，广东省广州市 510663
  • 作者简介:第一作者：李会萍，女，1980年生，广东省韶关市人，汉族，硕士，研究员，主要从事实验动物信息化与科技情报研究。
  • 基金资助:
    广州市基础与应用基础项目(202102080391)，项目负责人：李会萍

Animal models of Parkinson’s disease: research status and trend analysis

Li Huiping, Jia Huanhuan, Zhao Weibo   

  1. Guangdong Provincial Biotechnology Research Institute (Guangdong Provincial Laboratory Animals Monitoring Center), Guangzhou 510663, Guangdong Province, China
  • Received:2025-09-28 Revised:2025-12-08 Online:2026-12-18 Published:2026-04-30
  • Contact: Zhao Weibo, MS, Researcher, Guangdong Provincial Biotechnology Research Institute (Guangdong Provincial Laboratory Animals Monitoring Center), Guangzhou 510663, Guangdong Province, China
  • About author:Li Huiping, MS, Researcher, Guangdong Provincial Biotechnology Research Institute (Guangdong Provincial Laboratory Animals Monitoring Center), Guangzhou 510663, Guangdong Province, China
  • Supported by:
    Guangzhou Basic and Applied Basic Project, No. 202102080391 (to LHP)

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摘要：



文题释义：
帕金森病：是一种常见的老年神经系统退行性疾病，主要影响中老年人的神经系统，导致一系列运动和非运动症状。帕金森病的发病原因与黑质多巴胺能神经元变性死亡有关，具体原因尚未完全明确。
可视化知识图谱：指以图形化的方式呈现知识图谱中的实体、概念和关系，利用可视化工具和技术将知识图谱中的结构化数据以增强理解和洞见的方式展现出来。

背景：为进一步明确帕金森病的病因与发病机制，与临床更加接近的、标准化的帕金森病动物模型受到了广泛关注并取得了显著进展。
目的：梳理和总结帕金森病动物模型研究的现状、脉络和趋势。
方法：以中国知网和Web of Science数据库的10 170篇相关文献为数据样本，通过CiteSpace文献计量软件绘制帕金森病动物模型研究的关键词共现、聚类、突现词、文献发文量、国家/地区发文量、机构合作网络、文献被引等知识图谱，并进行分析。
结果与结论：国内外关于帕金森病动物模型研究的文献发文量总体呈波动上升趋势，Web of Science数据库的文献发文量增长显著。中国、美国是发文最多的国家，占总发文量的52.6%，成为该领域研究成果的主要贡献者。国内发文最多的机构是上海中医药大学(131篇)，国外发文最多的机构是哈佛大学(263篇)。国内外期刊及学科分布集中于神经科学、神经病学、分子生物学、中医学、基础医学、药理学等领域，尤其是中医学治疗帕金森病得到国内学者的高度重视，跨学科合作潜力巨大。与帕金森病动物模型相关的神经炎症、肠道菌群、氧化应激、线粒体功能障碍、α-突触核蛋白等病理机制是该领域的研究热点，铁死亡成为国内帕金森病机制研究的新兴主题。在帕金森病的病症治疗方面，除通过动物模型在中医、西医的帕金森病治疗研究不断深入之外，基因治疗、干细胞移植治疗等新型手段在帕金森病动物模型研究中提供了创新性的治疗策略，随着国家“脑科学计划”的推进以及基因编辑、人工智能、机器学习与脑机接口技术的发展，未来这些新技术在帕金森病研究中也具有一定的探索空间。

https://orcid.org/0000-0003-2268-5293 (李会萍) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 帕金森病, 动物模型, CiteSpace, 文献计量分析, 发病机制, 病症治疗

Abstract: BACKGROUND: To further elucidate the etiology and pathogenesis of Parkinson’s disease, standardized animal models that more closely mimic clinical conditions have garnered significant attention and achieved notable progress.
OBJECTIVE: To review and summarize the current status, development trajectory, and trends in Parkinson’s disease animal model research.
METHODS: A total of 10 170 relevant literature from two databases, CNKI and Web of Science, were used as data samples. CiteSpace bibliometric software was then used to draw and analyze knowledge graphs of co-occurrence, clustering, emergent terms of keywords, literature publication volume, national/regional publication volume, institutional cooperation network, and literature citation in Parkinson’s disease animal model research, followed by analysis.
RESULTS AND CONCLUSION: The overall publication volume of Parkinson’s disease animal model research, both domestically and internationally, has shown a fluctuating upward trend, with significant growth observed in the Web of Science database. China and the United States were the top publishing countries, accounting for 52.6% of total publications and emerging as primary contributors to research outcomes in this field. The leading domestic institution was Shanghai University of Traditional Chinese Medicine (131 papers), while internationally, Harvard University was the institution with the most publications (263 papers). Publications are domestic and foreign journals and disciplines including neuroscience, neurology, molecular biology, traditional Chinese medicine, basic medicine, and pharmacology, etc. Especially, traditional Chinese medicine has received high attention from domestic scholars in the treatment of Parkinson’s disease, and its interdisciplinary cooperation potential is enormous. Neuroinflammation, gut microbiota, oxidative stress, mitochondrial dysfunction, alpha synuclein and other pathological mechanisms related to Parkinson’s disease animal models are research hotspots in this field. Ferroptosis has become an emerging theme in the study of Parkinson’s disease mechanisms in China. In the treatment of Parkinson’s disease, in addition to the continuous deepening of Parkinson’s disease treatment research in traditional Chinese medicine and Western medicine through animal models, new methods such as gene therapy and stem cell transplantation have provided innovative treatment strategies in Parkinson’s disease animal model research. With the advancement of the national “China Brain Project” and developments in gene editing, artificial intelligence, machine learning, and brain-computer interface technologies, these emerging techniques also present significant exploration potential in future Parkinson’s disease research.


Key words: Parkinson’s disease, animal model, CiteSpace, bibliometric analysis, pathogenesis, symptomatic treatment

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