中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (35): 9336-9344.doi: 10.12307/2026.439

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

绝经后认知障碍：发展脉络与热点趋势的文献计量学分析

陈小霞1，2，赵利华2，李滔文1，2，覃义媚1，2，梁金玉1，2   

  1. 1广西中医药大学，广西壮族自治区南宁市   530001；2广西中医药大学第一附属医院，广西壮族自治区南宁市   530001
  • 收稿日期:2025-10-15 修回日期:2026-01-18 出版日期:2026-12-18 发布日期:2026-04-30
  • 通讯作者: 赵利华，博士，主任医师，博士生导师，广西中医药大学第一附属医院，广西壮族自治区南宁市 530001
  • 作者简介:陈小霞，女，1996年生，汉族，广西中医药大学在读博士，主要从事针灸防治老年病和治未病研究。
  • 基金资助:
    国家自然科学基金(82160933)，项目负责人：赵利华；广西壮族自治区自然科学基金(2022GXNSFAA035577)，项目负责人：赵利华；广西研究生教育创新计划项目(YCBZ2025191)，项目负责人：陈小霞

Postmenopausal cognitive impairment: a bibliometric analysis of developmental context and hot trends

Chen Xiaoxia1, 2, Zhao Lihua2, Li Taowen1, 2, Qin Yimei1, 2, Liang Jinyu1, 2   

  1. 1Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China; 2First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China

  • Received:2025-10-15 Revised:2026-01-18 Online:2026-12-18 Published:2026-04-30
  • Contact: Zhao Lihua, PhD, Chief physician, Doctoral supervisor, First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China
  • About author:Chen Xiaoxia, PhD candidate, Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China; First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    National Natural Science Foundation of China, No. 82160933 (to ZLH); Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 2022GXNSFAA035577 (to ZLH); Innovation Project of Guangxi Graduate Education, No. YCBZ2025191 (to CXX)

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摘要：



文题释义：
绝经后认知障碍：指女性经自然绝经或人工绝经(如双侧卵巢切除术)后出现的认知功能损害，病理生理机制主要与绝经后内源性雌激素水平急剧下降密切相关，同时叠加衰老等因素共同作用。绝经后认知障碍的核心临床特征包括情景记忆障碍(以近期事件记忆减退为典型表现)、执行功能受损(表现为任务规划与执行能力下降)及注意力维持障碍等。
文献计量学：是基于数学、统计学与情报学理论，以文献信息的数量特征、分布规律及相互关系为研究对象的定量分析方法，为揭示学科发展脉络、识别核心研究机构/作者、预判研究热点与前沿提供量化依据，是科研管理、学科评估及学术影响力评价的核心工具，为科研资源配置、学术政策制定提供数据支撑。

背景：当前针对绝经后认知障碍的纵向研究匮乏，尚无发展脉络与热点趋势的系统性文献计量学分析。
目的：借助文献计量学工具，系统性整合绝经后认知障碍相关文献，识别该领域研究进展和热点趋势，促进跨学科合作与临床转化。
方法：检索Web of Science核心合集数据库2005-01-01/2025-03-24期间发表的绝经后认知障碍相关文献，利用VOSviewer、R软件包“Bibliometrix”、CiteSpace等软件进行可视化分析。
结果与结论：共纳入1 452篇文献，涉及71个国家、1 830个机构、510种期刊和6 909位作者。绝经后认知障碍的年发文量呈波动增长趋势；美国在该领域占据绝对主导地位，且以斯坦福大学、匹兹堡大学、哈佛医学院和伊利诺伊大学为首；《Menopause-The Journal of the North American Menopause Society》发文量最多(78篇)，《JAMA-J Am Med Assoc》共被引次数最多(3 791次)；Espeland, Mark A.以发文量55篇文献位居第一，在共被引作者中，排名第一的是Shumaker, Sally A.(859次)；通过高频关键词“雌激素”(211次)和突现关键词“加用孕激素”(强度=15.77)、“雌激素替代疗法”(强度=15.57)可知，激素干预的长期效应和安全性始终是该领域研究核心。关键词聚类反映了4个研究方向，后续研究可着重构建“跨生命周期-多维度”的研究框架，这将有助于更全面地把握激素在女性不同生命阶段对认知功能和神经精神状态的作用机制。热点趋势主题的转变从单一议题(如磁共振成像、激素与认知)向多元健康议题(心理精神、肿瘤风险、心脑血管、代谢疾病、身体活动等)拓展和干预策略的非激素化转向，反映了学科发展趋势。
https://orcid.org/0009-0003-9175-2207 (陈小霞)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 绝经后认知障碍, 文献计量学, Web of Science, VOSviewer, CiteSpace, 可视化分析, 大数据分析, 热点趋势

Abstract: BACKGROUND: At present, there are few longitudinal studies on postmenopausal cognitive impairment, and there is no systematic bibliometric analysis of its development context and hot trends. 
OBJECTIVE: To systematically integrate the related research on postmenopausal cognitive impairment with the help of bibliometric tools, identify the research trends and hot trends in this field, and promote interdisciplinary cooperation and clinical transformation. 
METHODS: The Web of Science Core Collection database was retrieved for literature related to postmenopausal cognitive impairment published from January 1, 2005 to March 24, 2025. Visualization analysis was conducted using software such as VOSviewer, the R package “Bibliometrix,” and CiteSpace.
RESULTS AND CONCLUSION: A total of 1 452 articles were included, involving 71 countries, 1 830 institutions, 510 journals, and 6 909 authors. The annual number of publications on postmenopausal cognitive impairment showed a fluctuating upward trend. The United States occupied an absolute dominant position in this field, with Stanford University, University of Pittsburgh, Harvard Medical School, and University of Illinois at the forefront. Menopause - The Journal of the North American Menopause Society had the highest number of publications (78 articles), while JAMA - Journal of the American Medical Association had the highest total number of citations (3 791 times). Espeland, Mark A. ranked first with 55 published articles; among the authors by total citations, Shumaker, Sally A. took the top spot (859 citations). From the high-frequency keyword "estrogen" (211 occurrences) and the burst keywords "progestogen addition" (strength = 15.77) and "estrogen replacement therapy" (strength = 15.57), it can be concluded that the long-term effects and safety of hormonal interventions have always been the core of research in this field. Keyword clustering revealed four research directions. Future studies may focus on constructing a "cross life cycle – multi-dimensional" research framework, which will help to more comprehensively grasp the mechanism of action of hormones on woman's cognitive function and neuropsychiatric status at different life stages. The shift in hotspot trend themes from single topics (such as magnetic resonance imaging, hormones and cognition) to diverse health topics (psychiatry and psychology, cancer risk, cardiovascular and cerebrovascular diseases, metabolic diseases, physical activity, etc.) and the shift toward non-hormonal intervention strategies reflect the development trend of the discipline.


Key words: postmenopausal cognitive impairment, bibliometrics, Web of Science, VOSviewer, CiteSpace, visualization analysis, big data analysis, hotspot trends

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