中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (29): 7764-7772.doi: 10.12307/2026.269

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    

线粒体与脊髓损伤治疗相关前沿热点研究的文献计量分析

王  磊1，胡宝阳2，房  芳1   

  1. 1内蒙古医科大学通辽临床医学院，内蒙古自治区通辽市   028000；2通辽市人民医院脊柱外科，内蒙古自治区通辽市   028000
  • 收稿日期:2025-09-26 修回日期:2025-12-12 出版日期:2026-10-18 发布日期:2026-03-09
  • 通讯作者: 房芳，博士，主任医师，内蒙古医科大学通辽临床医学院，内蒙古自治区通辽市 028000
  • 作者简介:第一作者：王磊，男，2001年生，内蒙古自治区通辽市人，蒙古族，内蒙古医科大学通辽临床医学院在读硕士，主要从事脊髓损伤方向的研究。 并列第一作者：胡宝阳，男，1993年生，内蒙古自治区通辽市人，汉族，硕士，主治医师，主要从事脊髓损伤方向的研究。

Bibliometric analysis of research hotspots on mitochondria and spinal cord injury treatment

Wang Lei1, Hu Baoyang2, Fang Fang1   

  1. 1Tongliao Clinical Medical College, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China; 2Department of Spinal Surgery, Tongliao People’s Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China
    Wang Lei, MS candidate, Tongliao Clinical Medical College, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China
  • Received:2025-09-26 Revised:2025-12-12 Online:2026-10-18 Published:2026-03-09
  • Contact: Fang Fang, PhD, Chief physician, Department of Spinal Surgery, Tongliao People’s Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China
  • About author:Hu Baoyang, MS, Attending Physician, Department of Spinal Surgery, Tongliao People's Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China Wang Lei and Hu Baoyang contributed equally to this work.

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摘要：



文题释义：
线粒体：是一种存在于大多数真核细胞中的由两层膜包被的细胞器，是细胞中制造能量的结构，是细胞进行有氧呼吸的主要场所。线粒体不仅仅是能量的生产者，还参与了多种细胞过程，包括细胞凋亡、钙离子储存和调控、热量产生以及某些代谢途径。
文献计量学：利用数学、统计学、语言学等专业知识对一定范围内的相关文献进行归纳、整理，对该研究领域进行计量分析。通过文献计量学，从论文发文数量、研究中心、H指数、发文国家、作者、期刊影响因子、被引情况、共著分析、高被引文献分析、聚类分析等指标，了解有关线粒体治疗脊髓损伤领域研究现状、全球发展趋势及学术认知全貌。

背景：线粒体在脊髓损伤后轴突再生和细胞凋亡中起着重要作用，因此，线粒体成为治疗脊髓损伤研究领域中不可忽视的重要环节。
目的：归纳线粒体与脊髓损伤治疗相关文献，利用文献计量学，了解有关线粒体与脊髓损伤治疗领域研究现状、全球发展趋势及学术认知全貌。
方法：以Web of Science核心合集数据库为数据源，检索1990-2024年间线粒体与脊髓损伤治疗领域相关文献，运用CiteSpace 5.8和VOS Viewer 1.6.18软件进行可视化分析，绘制知识图谱，检测发文数量、中心性、H指数等指标，通过关键词分析、共被引期刊分析、共被引文献分析、高共被引文献分析、文献爆发分析等对相关文献进行分析，归纳该领域的研究热点和研究方向。
结果与结论：共纳入558篇文献进行文献计量学分析，涉及48个国家、3 036名作者、713家机构与252种期刊，为线粒体与脊髓损伤治疗领域做出贡献。分析结果显示，线粒体与脊髓损伤治疗领域发文量呈现逐年递增趋势，美国和中国在该领域的表现突出，论文发表数量、引用频次、核心作者及研究机构等方面均位居全球前列。当前，该领域研究热点聚焦于细胞凋亡、氧化应激等方向，未来研究方向可重点围绕分子作用机制、炎症反应及神经修复等关键问题展开探索。线粒体与脊髓损伤治疗领域极具发展前景，近年来该领域的整体研究水平稳步提高，但仍面临诸多挑战，如高质量文献数量有限、不同地区研究进展差异显著，这些问题有待于科研人员进一步完善。
https://orcid.org/0009-0003-3649-3468 (王磊) 


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 脊髓损伤, 线粒体, 文献计量学, 可视化分析, 研究热点, 趋势

Abstract: BACKGROUND: Mitochondria are vital for axonal regeneration and apoptosis following spinal cord injury, making them an essential area of therapeutic research for this condition.
OBJECTIVE: To summarize literature on mitochondria and spinal cord injury treatment, using bibliometric methods to elucidate the current research landscape, global trends, and comprehensive academic understanding in this field.
METHODS: We retrieved relevant literature published between 1990 and 2024 from the Web of Science Core Collection database on topics related to mitochondria and the treatment of spinal cord injury. Visual analysis was conducted using CiteSpace 5.8 and VOS Viewer 1.6.18 software to draw knowledge maps and examine metrics such as publications, centrality, and H-index. Keyword analysis, co-cited journal analysis, co-cited document analysis, highly co-cited document analysis, and publication burst analysis were conducted to identify research hotspots and directions within the field.
RESULTS AND CONCLUSION: A total of 558 publications were included in this bibliometric analysis, involving 48 countries, 3 036 authors, 713 institutions, and 252 journals contributing to the field of mitochondrial and spinal cord injury treatment. This analysis demonstrated a consistent annual rise in publications within this field, with the United States and China showing strong global performance in terms of publication output, citation frequency, key authors, and research institutions. Although apoptosis and oxidative stress remain current research hotspots, future work should delve into crucial aspects such as molecular mechanisms, inflammatory responses, and neural repair, recognizing the vital function of mitochondria in axonal regeneration and apoptosis following spinal injury. Mitochondria hold tremendous potential in the field of spinal cord injury treatment. While overall research standards in this area have steadily improved in recent years, significant challenges remain. These include a limited number of high-quality publications and substantial disparities in research progress across different regions. Researchers are therefore required to further refine their work to address these concerns.


Key words: spinal cord injury, mitochondria, bibliometrics, visualization analysis, research hotspots, trends

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