中国组织工程研究

中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (14): 2197-2201.doi: 10.12307/2024.330

• 肌肉肌腱韧带组织构建 tissue construction of the muscle, tendon and ligament • 上一篇    下一篇

云贵高原部分地区老年肌少症患病率及危险因素的横断面调查

王  继1，胡  立2，杨中亚1，韩  鹏3   

  1. 1六盘水师范学院体育学院，贵州省六盘水市  553004；2云南大学体育学院，云南省昆明市  650091；3哈尔滨体育学院运动人体科学学院，黑龙江省哈尔滨市  150008
  • 收稿日期:2023-04-18 接受日期:2023-05-22 出版日期:2024-05-18 发布日期:2023-07-28
  • 通讯作者: 韩鹏，博士，讲师，哈尔滨体育学院运动人体科学学院，黑龙江省哈尔滨市 150008
  • 作者简介:王继，男，1993年生，湖南省邵东市人，2018年北京体育大学毕业，硕士，讲师，主要从事慢病与运动干预研究。
  • 基金资助:
    贵州省教育厅青年科技人才成长项目(黔教合KY字[2020]113)，项目负责人：王继；哈尔滨体育学院引进人才科研启动费(RC21-202207)，项目负责人：韩鹏

A cross-sectional survey on the prevalence and risk factors of sarcopenia in the elderly in some areas of the Yunnan-Guizhou Plateau

Wang Ji1, Hu Li2, Yang Zhongya1, Han Peng3   

  1. 1College of Physical Education, Liupanshui Normal University, Liupanshui 553004, Guizhou Province, China; 2College of Physical Education, Yunnan University, Kunming 650091, Yunnan Province, China; 3College of Sports and Human Sciences, Harbin Sport University, Harbin 150008, Heilongjiang Province, China
  • Received:2023-04-18 Accepted:2023-05-22 Online:2024-05-18 Published:2023-07-28
  • Contact: Han Peng, MD, Lecturer, College of Sports and Human Sciences, Harbin Sport University, Harbin 150008, Heilongjiang Province, China
  • About author:Wang Ji, Master, Lecturer, College of Physical Education, Liupanshui Normal University, Liupanshui 553004, Guizhou Province, China
  • Supported by:
    Young Science and Technology Talents Growth Project of Guizhou Provincial Department of Education, No. KY[2020]113 (to WJ); Introduced Talents Scientific Research Start-up Fee of Harbin Sport University, No. RC21-202207 (to HP)

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摘要：


文题释义：

肌少症：指由衰老引起的骨骼肌质量下降和肌肉力量减退，是一种增龄过程中常见的退行性肌肉疾病，发病过程受到多种肌源性和神经源性因素的影响。
横断面调查：又称横断面研究，因为所获得的描述性资料是在某一时点或在一个较短时间区间内收集的，所以它客观地反映了这一时点的疾病分布以及人们某些特征与疾病之间的关联。


背景：目前中国关于肌少症的流行病学研究资料集中在部分省会城市和发达地区，而云贵高原地区老年人肌少症的研究则刚起步，对肌少症的发生发展机制、影响因素和防治方法的认识还存在不足。

目的：基于2019年亚洲肌少症工作组标准(AWGS2019)对世居云贵高原地区老年人进行肌少症筛查和发病风险评估，分析云贵高原部分地区老年人肌少症的患病率及风险因素。
方法：在贵州省六盘水市和云南省昆明市招募老年研究对象1 327名(男性 650名，女性677名)，采用亚洲肌少症工作组标准(AWGS2019)评估筛查肌少症并采集受试者的社会人口学特征、临床资料和体力活动水平等资料，采用单因素分析筛查肌少症的可能影响因素，其中计数资料组间比较采用χ2检验、计量资料组间比较采用t检验，将通过单因素筛查的指标纳入二元logistic回归模型，评估肌少症的危险因素，并计算优势比和95%置信度区间。

结果与结论：①云贵高原地区老年人肌少症检出率为14.62%(男性12.73%，女性16.49%)；②年龄增长(OR=1.158，95%CI：1.133-1.185)、女性(OR=2.416，95%CI：1.629-3.586)、空腹血糖≥7.0 mmol/L(OR=1.653，95%CI：1.071-2.551)、吸烟(OR=1.595，95%CI：1.043-2.438)和低体力活动水平(OR=1.778，95%CI：1.154-2.737)均是肌少症的独立危险因素，而体质量指数则是肌少症的保护因素(OR=0.708，95%CI：0.583-0.859)；③结果表明，年龄增长、女性、空腹血糖≥7.0 mmol/L、吸烟和低体力活动水平均增加了肌少症的患病风险，而体质量指数的增加则可以降低肌少症的患病风险，提示老年人(尤其是女性)在增龄过程中除了保持健康生活方式外，还应该尝试维持一个略高的体质量指数水平，以降低增龄过程中罹患肌少症的风险。     

https://orcid.org/0000-0003-0979-7741(王继)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 肌少症, 骨骼肌, 生活方式, 体力活动, 危险因素

Abstract: BACKGROUND: Epidemiological research data on sarcopenia in China are concentrated in some provincial capitals and developed areas, while research on sarcopenia in the elderly in the Yunnan-Guizhou Plateau is at the initial stage, and there is still a lack of understanding of the development mechanism, influencing factors and prevention methods of sarcopenia.
OBJECTIVE: Based on the 2019 Asian Sarcopenia Working Group Standard (AWGS2019), to assess sarcopenia in the elderly in the Yunnan-Guizhou Plateau, while analyzing the prevalence and risk factors of sarcopenia in the elderly. 
METHODS: A total of 1 327 elderly study subjects (650 males and 677 females) were recruited and their socio-demographic characteristics, clinical data and physical activity levels were collected. The prevalence of sarcopenia was screened using the AWGS2019 criteria. The possible influencing factors for sarcopenia were screened by univariate analysis, including χ2 test for comparing count data and t-test for comparing measurement data, and the indicators through univariate screening were included in the binary logistic regression model to assess the risk factors for sarcopenia, and then the odds ratio (OR) and 95% confidence interval (CI) were calculated. 
RESULTS AND CONCLUSION: The prevalence of sarcopenia in the elderly in the Yunnan-Guizhou Plateau was 14.62% (12.73% male and 16.49% female). Aging (OR=1.158, 95% CI: 1.133-1.185), female (OR=2.416, 95% CI: 1.629-3.586), fasting blood glucose ≥ 7.0 mmol/L (OR=1.653, 95% CI: 1.071-2.551), smoking (OR=1.595, 95% CI: 1.043-2.438) and a low physical activity level (OR=1.778, 95% CI: 1.154-2.737) were all independent risk factors for sarcopenia, while body mass index was a protective factor for sarcopenia (OR=0.708, 95% CI: 0.583-0.859). These findings indicate that aging, female, fasting glucose ≥ 7.0 mmol/L, smoking and low physical activity levels all increase the risk of sarcopenia, while increased body mass index can decrease the risk of sarcopenia. To conclude, the elderly (especially women) should maintain a healthy lifestyle and slightly higher body mass index levels during the aging process, thus reducing the risk of sarcopenia.

Key words: sarcopenia, skeletal muscle, lifestyle, physical activity, risk factor

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