中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (10): 1611-1616.doi: 10.3969/j.issn.2095-4344.1620

• 生物材料综述 biomaterial review • 上一篇    下一篇

软骨修复中壳聚糖复合水凝胶的应用与价值

杨龄坚,李彦林,贾  笛,何映红,向耀宇   

  1. 昆明医科大学第一附属医院运动医学科,云南省昆明市 650000
  • 收稿日期:2018-11-13
  • 通讯作者: 李彦林,博士生导师,主任医师,昆明医科大学第一附属医院运动医学科,云南省昆明市 650000
  • 作者简介:杨龄坚,男,1992年生,云南省元谋县人,汉族,昆明医科大学在读硕士,主要从事骨关节损伤的修复与重建研究。
  • 基金资助:

    国家自然科学基金(81460340,81760403),项目负责人:李彦林

Application of chitosan hydrogels in cartilage repair

Yang Lingjian, Li Yanlin, Jia Di, He Yinghong, Xiang Yaoyu   

  1. Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China
  • Received:2018-11-13
  • Contact: Li Yanlin, Doctoral supervisor, Chief physician, Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China
  • About author:Yang Lingjian, Master candidate, Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81460340 and 81760403 (both to LYL)

摘要:

文章快速阅读:

 
文题释义:
壳聚糖复合水凝胶:以壳聚糖良好的生物相容性、可塑性等为基础,运用化学偶联、3D打印、物理冷冻干燥等技术复合其他化合物,制备仿生软骨组织工程支架材料,使其有望成为治疗软骨缺损、骨关节炎的新兴方式。

智能型壳聚糖水凝胶的优点:①可模拟细胞外基质环境,给组织修复提供支架和细胞生长微环境;②以半溶液性质载药,药物在局部温度的影响下形成水凝胶,靶向治疗且避免药物过快流失;③与不同化合物通过物理/化学方法结合,构成三维网状交联结构,形成新兴组织工程修复支架等。

 

背景:壳聚糖以广泛的生物来源、简单的制备工艺及优良的生物相容性成为软骨修复材料的研究热点之一。
目的:围绕壳聚糖类复合水凝胶的特点及在软骨修复中的应用展开综述。
方法:应用计算机检索PubMed数据库和CNKI数据库,中文关键词为“壳聚糖,壳聚糖水凝胶,软骨修复,组织工程”,英文检索词为“chitosan;chitosan Hydrogels;Cartilage repair;tissue engineering”,检索2000年1月至2018年3月发表的文献,将所有文章进行初步筛选后,对保留的文章进一步详细分析、归纳并总结。
结果与结论:壳聚糖具有良好的生物相容性、低毒性、低免疫原性,在不同的物理或化学的改良下可负载多种生长因子、种子细胞,在组织工程软骨修复中取得了令人可喜的进展。随着科技的进步及对软骨及软骨下骨组织结构的了解,壳聚糖仿生水凝胶拓宽了壳聚糖的应用范围。但随着研究的进一步推进,壳聚糖在体内修复的分子机制、降解过程仍然存在很多争议,需要广大学者进一步的研究与探索。

 

ORCID: 0000-0003-3038-8563(杨龄坚)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 骨科材料, 壳聚糖, 水凝胶, 组织工程, 软骨修复, 生物材料

Abstract:

BACKGROUND: Chitosan has become a research hotspot of cartilage repair materials because of a wide range of biological sources, simple preparation processes and excellent biocompatibility.

OBJECTIVE: To review the characteristics of chitosan hydrogels and their application in cartilage repair.

METHODS: PubMed and CNKI databases were searched by computer with the keywords of “chitosan; chitosan hydrogel; cartilage repair; tissue engineering” in English and Chinese, respectively. The time range was from January 2000 to March 2018. After initial screening, the retained articles were further analyzed, concluded and summarized.

RESULTS AND CONCLUSION: Chitosan has good biocompatibility, low toxicity, low immunogenicity, and can load multiple growth factors and seed cells with different physical or chemical improvements. Encouraging progress in tissue engineering cartilage repair has been achieved. With the development of technology and the understanding of cartilage and subchondral bone structure, the application range of chitosan biomimetic hydrogel has been broadened. However, the molecular mechanism and degradation process of chitosan in vivo still have a lot of controversies, and further research and exploration are needed.

 

Key words: Chitosan;, Hydrogels, Cartilage, Articular, Tissue Engineering

中图分类号: