中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (52): 7885-7890.doi: 10.3969/j.issn.2095-4344.2016.52.019

• 生物材料综述 biomaterial review • 上一篇    下一篇

颅骨修补材料研究现状及3D打印技术应用前景

卢  磊1，2，陈旭义2，3，4，李一鹏1，2，刚  琳1，2，涂  悦2，3，4
  

  1. 1天津中医药大学，天津市  300193；2天津市神经创伤修复重点实验室，天津市  300162；3武警后勤学院附属医院脑创伤与神经疾病研究所，天津市  300162；4武警后勤学院附属医院，天津市  300162
  • 收稿日期:2016-09-19 出版日期:2016-12-16 发布日期:2016-12-16
  • 通讯作者: 涂悦，教授，博士生导师，武警后勤学院附属医院中国武警脑科医院，天津市 300162
  • 作者简介:卢磊，男，1988年生，河南省南阳市人，汉族，天津中医药大学在读硕士，主要从事神经内科，组织工程等方面的研究。 并列第一作者：陈旭义，男，浙江省温州市人，汉族，博士，副主任医师，硕士生导师，主要从事神经创伤与再生、组织工程、三维打印、生物力学研究及神经外科研究。
  • 基金资助:

    天津市科技支撑计划重点项目(14ZCZDGX00500)

Research status of skull repair materials and the prospect of three-dimensional printing technology

Lu Lei1, 2, Chen Xu-yi2, 3, 4, Li Yi-peng1, 2, Gang Lin1, 2, Tu Yue2, 3, 4
  

  1. 1Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; 2Tianjin Key Laboratory of Neurological Trauma Repair, Tianjin 300162, China; 3Institute of Traumatic Brain Injury and Neurology, Affiliated Hospital of Logistics University of CAPF, Tianjin 300162, China; 4Affiliated Hospital of Logistics College of CAPF, Tianjin 300162, China
  • Received:2016-09-19 Online:2016-12-16 Published:2016-12-16
  • Contact: Tu Yue, Professor, Doctoral supervisor, Tianjin Key Laboratory of Neurological Trauma Repair, Tianjin 300162, China; Institute of Traumatic Brain Injury and Neurology, Affiliated Hospital of Logistics University of CAPF, Tianjin 300162, China; Affiliated Hospital of Logistics College of CAPF, Tianjin 300162, China
  • About author:Lu Lei, Studying for master’s degree, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Key Laboratory of Neurological Trauma Repair, Tianjin 300162, ChinaChen Xu-yi, M.D., Associate chief physician, Master’s supervisor, Tianjin Key Laboratory of Neurological Trauma Repair, Tianjin 300162, China; Institute of Traumatic Brain Injury and Neurology, Affiliated Hospital of Logistics University of CAPF, Tianjin 300162, China; Affiliated Hospital of Logistics College of CAPF, Tianjin 300162, China Lu Lei and Chen Xu-yi contributed equally to this work.
  • Supported by:

    the Science and Technology Support Program of Tianjin, No. 14ZCZDGX00500

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被引次数

2

摘要：

文章快速阅读：

 

文题释义：
骨组织工程支架材料：大体可以分为：①天然材料，包括壳聚糖、胶原蛋白、明胶、藻酸盐和丝素蛋白等。②人工合成高分子材料，包括聚乳酸、聚乙醇酸和聚乳酸-羟基乙酸共聚物等。③人工合成无机材料，包括羟基磷灰石和磷酸三钙等。
3D打印技术：是一种快速成型技术，它是以计算机辅助设计模型的几何信息为基础，通过成型设备把材料逐层堆积得到三维实体。3D打印技术可以个性化打印形状，精确吻合缺损；可以通过特定的程序设定打印出有利于细胞增殖的孔隙，增强支架的骨诱导性、骨传导性、骨再生。

背景：应用颅骨修补材料不仅能恢复正常的颅骨形态，而且对恢复脑功能有重要意义。
目的：对聚醚醚酮、钛合金和组织工程技术在颅骨修补方面的研究现状以及与3D打印技术联合应用的前景做一个总结。
方法：检索中国知网数据库、和PubMed数据库1995至2016年发表的有关颅骨修复材料的文献，英文检索词为“bone regeneration material in calvarial，3d printing bone scaffold ”，中文检索词为“颅骨修补材料，3D打印骨支架”。
结果与结论：钛合金和聚醚醚酮材料虽已在临床上使用，但钛合金有导电性、导热性，聚醚醚酮不参与缺损部位骨整合，有脱落或移位的可能。组织工程技术参与颅骨组织重建，修复效果满意，但支架材料选择和制备问题、种子细胞获取问题及生长因子缓释问题需要克服。3D打印技术可个性化打印形状，精确吻合缺损，但对原材料要求高，需要有良好的生物相容性及良好的生物力学性能。组织工程与3D打印技术相结合应用于颅骨修补应用前景广阔。

关键词: 生物材料, 骨生物材料, 颅骨修补, 聚醚醚酮, 钛合金, 组织工程, 3D打印技术

Abstract:

BACKGROUND: Skull repair materials cannot only restore the normal shape of the skull, but also play an important role in brain functional recovery.
OBJECTIVE: To summarize the research status of polyetheretherketone (PEEK), titanium alloy and tissue engineering technique in cranioplasty and the prospect of three-dimensional (3D) printing technology.
METHODS: Literatures related to skull repair materials were retrieved in databases of CNKI and PubMed published from 1995 to 2016, using the keywords of “bone regeneration material in calvarial, 3d printing bone scaffold” in Chinese and English, respectively. 
RESULTS AND CONCLUSION: Although titanium and PEEK have been used in clinic, titanium holds conductivity, thermal conductivity, while PEEK that may be displaced or lost is not involved in osseointegration. Tissue engineering technology participates in the skull tissue reconstruction, achieving satisfactory repair outcomes, but the problems of scaffold selection and preparation, seed cell obtainment, and growth factor release need to be overcomed. 3D printing technology can print personalized shape, fit the defect precisely, but the raw materials should have good biocompatibility and biomechanical property. Combination of tissue engineering technology with 3D printing technology shows a broad prospect in cranioplasty.

Key words: Skull, Titanium, Tissue Engineering

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