中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (52): 9828-9835.doi: 10.3969/j.issn.2095-4344.2012.52.027

• 骨与关节综述 bone and joint review • 上一篇    下一篇

细胞因子在骨性关节炎中的表达与应用

任红革1，崔逢德2   

  1. 1延边大学附属医院骨1科，吉林省延吉市 133000
    2延边大学医学部免疫学与病原生物学教研部，吉林省延吉市133002
  • 收稿日期:2012-08-25 修回日期:2012-09-15 出版日期:2012-12-23 发布日期:2013-03-12
  • 通讯作者: 崔逢德，教授，博士生导师，延边大学医学部免疫学与病原微生物教研部，吉林省延吉市 133000 fdcui@ybu.edu.cn
  • 作者简介:任红革☆，男，1975年生，吉林省和龙市人，朝鲜族，1998年延边大学医学院毕业，博士，副主任医师，主要从事骨关节疾病与组织工程研究。 Renhg196@sina.com

Expression and application of cytokines in osteoarthritis

Ren Hong-ge1, Cui Feng-de2   

  1. 1First Department of Orthopedic Surgery, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China
    2Department of Immunology and Pathogenic Biology, Yanbian University Health Science Center, Yanji 133002, Jilin Province, China
  • Received:2012-08-25 Revised:2012-09-15 Online:2012-12-23 Published:2013-03-12
  • Contact: Cui Feng-de, Professor, Doctoral supervisor, Department of Immunology and Pathogenic Biology， Yanbian University Healthy Science Center, Yanji 133002, Jilin Province, China fdcui@ybu.edu.cn
  • About author:Ren Hong-ge☆, Doctor, Associate chief physician, First Department of Orthopedic Surgery, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin Province, China renhg196@sina.com

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1167

被引次数

58

摘要：

背景：骨性关节炎是生物学、生物化学、分子生物学、酶的反馈作用等复杂的多种机制相互作用的结果，其病理过程与细胞因子密切相关。
目的：总结细胞因子在骨性关节炎发生、发展过程中作用的研究现状。
方法：由第一作者用计算机检索万方数据库(2000至2012年)和PubMed 数据库(2000至2012年)收录的细胞因子与骨性关节炎相关论文报告。
结果与结论：共纳入细胞因子与骨性关节炎相关文献69篇。细胞因子在骨性关节炎发生、发展过程中起重要作用，能促进骨性关节炎软骨降解、滑膜炎症及软骨下骨的吸收，部分细胞因子也有抑制骨性关节炎病变发展的作用。与分解代谢有关的细胞因子主要有基质金属蛋白酶；与合成代谢有关的细胞因子主要有转化生长因子，骨形态发生蛋白，胰岛素样生长因子，成纤维细胞生长因子和血管内皮细胞生长因子；在关节组织中发现的影响细胞功能的炎性因子包括白细胞介素、趋化因子和肿瘤坏死因子等。但细胞因子在骨性关节炎发生、发展过程中作用机制及临床应用需要进一步研究。

关键词: 骨性关节炎, 细胞因子, 白细胞介素, 基因, 趋化因子, 肿瘤坏死因子, 基质金属蛋白酶, 转化生长因子, 骨形态发生蛋白, 胰岛素样生长因子, 骨组织工程

Abstract:

BACKGROUND: Osteoarthritis is a kind of normal disease, results from a complex system of interacting mechanical, biological, biochemical, molecular and enzymatic feedback loops. Cytokines are closely related to the pathological process of osteoarthritis.
OBJECTIVE: To summarize the research progress of cytokines in the occurring and development of osteoarthritis.
METHODS: An online search of Wanfang database and PubMed database was performed by the first author for articles published between 2000 and 2012 that related to cytokines and osteoarthritis.
RESULTS AND CONCLUSION: A total of 69 articles on the application of cytokines in osteoarthritis were included. Cytokines play an important role in the occurring and development process of osteoarthritis; cytokines can promote the degradation of osteoarthritic cartilage, synovitis and resorption of subchondral bone. Some cytokines also have an inhibitory effect in the development of osteoarthritis. Matrix metalloproteinase is related to catabolism; transforming growth factor, bone morphogenic protein, insulin-like growth factor, fibroblast growth factor and vascular endothelial growth factor are related to anabolism. Inflammatory factors which affect the function of joint cells include interleukin, chemokine and tumor necrosis factor. But the mechanisms of cytokines in the occurring and the development of osteoarthritis and clinical application of cytokines need further study.

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